2008
DOI: 10.7326/0003-4819-148-11-200806030-00225
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Abstract: Subclinical hypothyroidism and hyperthyroidism may be associated with a modest increased risk for CHD and mortality, with lower risk estimates when pooling higher-quality studies and larger CIs for subclinical hyperthyroidism.

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Cited by 422 publications
(353 citation statements)
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“…Several studies have provided evidence that TSH in the upper reference range is often associated with primary cardiovascular risk factors in susceptible individuals (43). Early treatment would prevent progression to subnormal values, but the balance between benefits and harm is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have provided evidence that TSH in the upper reference range is often associated with primary cardiovascular risk factors in susceptible individuals (43). Early treatment would prevent progression to subnormal values, but the balance between benefits and harm is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…In two study-level meta-analyses (168,169) (B), SH correlated significantly with an increased risk of CHD, but in other three meta-analyses (170)(171)(172) (A,B,B), risks for CHD and mortality were only modestly increased. In one of these studies (171) (B), significance was obtained only for participants younger than 65 years of age.…”
Section: Is Subclinical Hypothyroidism Associated To Cardiovascular Rmentioning
confidence: 99%
“…Thus, decreased serum TSH levels have been reported to be associated with surrogate markers of cardiovascular mortality including carotid wall thickness (1), atrial fibrillation (2, 3), high plasma fibrinogen levels (4), and left ventricular hypertrophy (5,6). However, results of studies on the association between decreased serum TSH levels or subclinical hyperthyroidism (3,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and mortality are conflicting. With respect to cardiovascular mortality, most studies (3,11,12,18) and all meta-analyses (10,14,17) detected no association between decreased serum TSH levels or hyperthyroidism and mortality, while two studies did detect an association (7,9).…”
Section: Introductionmentioning
confidence: 99%
“…However, results of studies on the association between decreased serum TSH levels or subclinical hyperthyroidism (3,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and mortality are conflicting. With respect to cardiovascular mortality, most studies (3,11,12,18) and all meta-analyses (10,14,17) detected no association between decreased serum TSH levels or hyperthyroidism and mortality, while two studies did detect an association (7,9). Regarding all-cause mortality, one study (7) demonstrated an increased mortality risk in subjects with decreased serum TSH levels, whereas two others did not (12,16).…”
Section: Introductionmentioning
confidence: 99%