Meta‐analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon‐α and ribavirin

Abstract

SUMMARY BackgroundInterleukin (IL) 28B single nucleotide polymorphisms can predict sustained virological response (SVR) in hepatitis C virus (HCV) patients following pegylated interferon-alpha (PEG IFN-a) and ribavirin treatment.

Genetic Variation in Interleukin-28B and Response to Peg-IFNα-2a/RBV Combination Therapy in Patients with Hepatitis C Virus Infection

“…The CC genotype of rs12979860 occurred in 48.6% of patients who achieved SVR, and 47.9% of patients who were infected with HCV subtype 1b, which were significantly higher than the corresponding values of CT and TT genotypes. These findings are consistent with the results of other studies in different ethnic groups (29). Based on these findings, the rs12979860 CC genotype could constitute an effective pre-treatment predictor in Azerbaijani chronic hepatitis C patients, especially when associated with HCV subtype 1b.…”

Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India

“…29 Other studies 30,31 have also demonstratedthe association of IL28B SNPs with SVR in genotype 2/3 HCV infections. However, none of these studies have exclusively examined this SNP in genotype 3 HCV patients.Besides these three studies, others have failed to show any significant association betweenIL28B polymorphisms and SVR in genotypes 2 and 3 HCV-infected patients 32 although all studies have shown an association with RVR. A recent report also shows significant association between a novelIL28B SNP (ss469415590; encoding IFN-L4) with SVR 33 in genotype 2/3 HCV infections.Therefore, the association of IL28B SNPs and SVR in genotype 2/3 HCV infections remains controversial.…”

Management of Chronic Hepatitis C Virus Infection: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases

“…HCV genotip 1 ile infekte olan hastalarda, IL28B için rs12979860 CC genotipi taşıyan hastalarda KVY oranları daha yüksektir (90). HCV genotip 2/3 ile infekte hastalarda da, HCV genotip 1 ile infekte hastalardaki kadar kesin olmamakla birlikte, ILB28 gen polimorfizmiyle KVY arasında ilişki saptanmıştır (91).…”