Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus

Mao, Hongyan; Li, Qin; Gao, Shujun

doi:10.1371/journal.pone.0045882

Cited by 112 publications

(113 citation statements)

References 57 publications

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“…GDM is the most common metabolic disorder during pregnancy, and shows certain similarities to the pathogenesis and clinical characteristics of T2D, such as IR (Mao et al, 2012). During pregnancy, the placenta should be secreting placental growth hormone and placental lactogen, which is antagonistic towards insulin; free fatty acids increase, and the utilization of insulin towards glucose should decrease, thereby increasing IR.…”

Section: Discussionmentioning

confidence: 99%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differences between fasting blood glucose, fasting insulin, homeostatic model assessment (HOMA)-insulin resistance, and HOMA-b levels of pregnant women with different genotypes were compared. MIF genotype distributions were significantly different in the GDM group compared to the control group (P < 0.05). No significant difference was observed in the allele distributions of MIF rs1007888 between the GDM group and control group (P > 0.05). GDM patients had higher fasting blood glucose, fasting insulin, and HOMA-insulin resistance levels, but lower HOMA-b levels than normal gestational women (P < 0.05). Fasting blood glucose, fasting insulin, and HOMA-insulin resistance in pregnant women with the GG genotype were significantly higher than those with GA and AA genotypes, while HOMA-b in pregnant women with the GG genotype was lower (all P < 0.05). Our findings demonstrated the associations among MIF polymorphism rs1007888, insulin resistance, and pancreatic β cell functions in GDM patients. The GG genotype of MIF rs1007888 may be a genetic susceptibility factor in the pathogenesis of GDM.

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Section: Discussionmentioning

confidence: 99%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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“…Son yıllarda farklı popülasyonlarda KCNJ11 genindeki polimorfizmlerin GDM ile ilişkili olduğuna dair çalış-malar da rapor edilmiştir (32)(33)(34) …”

Section: Discussionunclassified

Gestasyonel diyabet gelişiminde KCNJ11 geninin rolü

Bozkurt¹,

Arıkoğlu²,

Baldane³

2015

GenelTipDer

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“…The prevalence of GDM shows an increasing trend in most racial/ethnic groups and parallels the global epidemic of obesity and type 2 diabetes [3]. GDM and type 2 diabetes have many risk factors in common and they share the same genetic susceptibility [4,5]. Both are characterised by insulin resistance and an inability of the beta cells to compensate with a sufficient increase in insulin secretion [4].…”

Section: Gdm Gestational Diabetes Mellitusmentioning

confidence: 99%

Gestational diabetes: what’s up?

Berntorp

2016

Diabetologia

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GDM and maternal obesity are independently associated with adverse pregnancy outcomes, and children born to mothers with GDM and overweight/obesity are more likely to be macrosomic and large for their gestational age [9][10][11]. In addition to short-term complications, they also have an increased risk of long-term complications similar to those in their mothers [12,13]. Studies indicate that offspring exposed to maternal diabetes or GDM in utero are at a higher risk of developing childhood obesity and glucose intolerance in early adulthood than offspring not exposed to maternal diabetes [12,14]. Moreover, if the offspring is female, she is more likely to develop GDM herself and thereby create a vicious circle. Prevention of GDM and fetal over-nutrition in pregnancy could therefore be important strategies to interrupt this trans-generational cycle of obesity and diabetes (Fig. 1).To date, several studies have demonstrated the effectiveness of lifestyle interventions in the prevention of type 2 diabetes [15]. A beneficial effect on the risk of diabetes was also found in the Diabetes Prevention Program in women with a history of GDM, which was sustained during a 10-year follow-up period [16]. Since obesity is one of the most powerful modifiable risk factors for GDM in pregnant women [12,17], many intervention studies have focused on reducing weight or on reducing gestational weight gain in pregnancy, most often by changes in diet and physical activity. The effects of combined diet and exercise interventions during pregnancy were recently reviewed by Cochrane [18]. No clear evidence for the prevention of GDM was found. In contrast, a newly published meta-analysis concluded that moderate exercise programmes initiated early during pregnancy reduce the risk of GDM and excessive gestational weight gain [19]. Ideally, interventions aimed at improving metabolic conditions and placental function in obese women should take place before pregnancy, prior to conception [20]. Interestingly, Zhang et al recently reported that adherence to a healthy lifestyle in the Diabetologia

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Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus

Cited by 112 publications

References 57 publications

Association between macrophage migration inhibitory factor rs1007888 and GDM

Association between macrophage migration inhibitory factor rs1007888 and GDM

Gestasyonel diyabet gelişiminde KCNJ11 geninin rolü

Gestational diabetes: what’s up?

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