Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients

Parker, Carmen Black; Miller, Brian J.

doi:10.1016/j.biopsych.2014.10.014

Cited by 291 publications

(244 citation statements)

References 47 publications

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“…Recent reports correlate suicide-related attempts with an inflammatory state, including increased levels of blood tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and decreased levels of IL-2. [37][38][39] Our findings are supported by prior studies, which were carried out with depressed subjects. Recently, Gibbs et al 38 found that as CRP level increased, the likelihood of patients' association with the suicidal group increased.…”

Section: Anatolian Journal Of Psychiatry 2017; 18(5):438-445supporting

confidence: 90%

The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

Ekinci¹,

Ekinci²

2017

Anadolu Psikiyatri Derg

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Section: Anatolian Journal Of Psychiatry 2017; 18(5):438-445supporting

confidence: 90%

The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

Ekinci¹,

Ekinci²

2017

Anadolu Psikiyatri Derg

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“…Administrating LPS and/or pro-inflammatory mediators induces depressive-like behaviors including impairment of sucrose preference and loss of hope to escape from despairing environments [32,33]. Meta-analyses of studies reported higher levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in depressed patients [34,35]. Therefore, it appears that anyone who wants to cope with depressive symptoms should inhibit microglial overactivation.…”

Section: Discussionmentioning

confidence: 98%

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

et al. 2017

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Recently, the loss and dystrophy of hippocampal microglia induced by chronic unpredictable stress (CUS) has been reported to mediate the development of major depression in mice whose microglial cells were labeled with enhanced green fluorescent protein-conjuncted-CX3C receptor type 1. However, whether this happens in endogenous microglia with no genetic intervention remains unclear. Here, we addressed this issue in mice treated with different types of chronic stresses, including the CUS, chronic restraint stress (CRS) and chronic social defeat stress (CSDS). Results showed that the cellular numbers, process lengths, soma areas and activation markers of endogenous hippocampal but not cortical microglia, were markedly reduced by CUS, CRS and CSDS treatment. Administration of mice with two classical stimulators of microglia, lipopolysaccharide (LPS) or macrophage colony-stimulating factor (M-CSF), reversed the CUS-, CRS- and CSDS-induced reductions in endogenous hippocampal microglial numbers, and also improved the CUS-, CRS- or CSDS-induced behavioral abnormalities, including the increases in the immobile time in the forced swimming test and tail suspension test, the inhibition of sucrose preference, and the decrease in the time spent in the center of open field. Furthermore, inhibition of the initial activation of hippocampal microglia by minocycline pretreatment also reversed the reduction in hippocampal microglial numbers as well as the behavioral abnormalities induced by CUS, CRS and CSDS treatment. These results provide compelling evidences to show that different types of chronic stresses can trigger the loss of endogenous hippocampal microglia and restoration of microglial numbers may have therapeutic values in major depression.

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“…Interestingly, a meta-analysis of 18 studies, comprising 583 depressed patients with suicidality, 315 patients without suicidality and 845 control subjects, demonstrated that high levels of IL-1-beta and IL-6 correlated with patients with suicidality, as compared to patients without suicidality and control subjects. Hence, IL-1-beta and IL-6 may aid in the ability to distinguish between suicidal and non-suicidal patients [146]. The immune-cytokine network has powerful control over the brain, increasing its sensitivity to stress, anxiety and depression, hence it is imperative to further understand the role the immune system plays in depression.…”

Section: Future Prospectsmentioning

confidence: 99%

The Effects of Vitamin B in Depression

Mikkelsen¹,

Stojanovska²,

Apostolopoulos

2016

CMC

130

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Abstract:Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins are required for proper functioning of the methylation cycle, monoamine oxidase production, DNA synthesis and the repair and maintenance of phospholipids. Vitamin B deficiency could influence memory function, cognitive impairment and dementia. In particular, vitamins B1, B3, B6, B9 and B12 are essential for neuronal function and deficiencies have been linked to depression. We discuss the causes of depression and the neurochemical pathways in depression. In particular, we provide evidence that vitamin B contributes to the complexity of depressive symptoms.

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Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients

Cited by 291 publications

References 47 publications

The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

The Effects of Vitamin B in Depression

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