Meta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder

Rotgé, Jean-Yves; Guehl, Dominique; Dilharreguy, Bixente; Tignol, Jean-Pierre; Bioulac, Bernard; Allard, Michèle; Burbaud, Pierre; Aouizerate, Bruno

doi:10.1016/j.biopsych.2008.06.019

Cited by 245 publications

(194 citation statements)

References 47 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Recently, a prior meta-analysis of ROI volume studies in OCD reported a smaller volume in the OFC, in the anterior cingulate cortex (ACC), and a higher volume in the thalamus, but no change in the basal ganglia (Rotge et al, 2009). The results from this ROI meta-analysis seem to be in contrast to the present findings from a VBM meta-analysis.…”

Section: Discussioncontrasting

confidence: 99%

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Rotgé

Langbour

Guehl

et al. 2009

Neuropsychopharmacol

Self Cite

195

149

View full text Add to dashboard Cite

Many voxel-based morphometry (VBM) studies have found abnormalities in gray matter density (GMD) in obsessive-compulsive disorder (OCD). Here, we performed a quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls (HC). A literature search identified 10 articles that included 343 OCD patients and 318 HC. Anatomic likelihood estimation meta-analyses were performed to assess GMD changes in OCD patients relative to HC. GMD was smaller in parieto-frontal cortical regions, including the supramarginal gyrus, the dorsolateral prefrontal cortex, and the orbitofrontal cortex, and greater in the basal ganglia (putamen) and the anterior prefrontal cortex in OCD patients relative to HC. No significant differences were found between children and adults. Our findings indicate differences in GMD in parieto-frontal areas and the basal ganglia between OCD patients and HC. We conclude that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD pathophysiology.

show abstract

Section: Discussioncontrasting

confidence: 99%

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Rotgé

Langbour

Guehl

et al. 2009

Neuropsychopharmacol

Self Cite

195

149

View full text Add to dashboard Cite

show abstract

“…Another meta-analysis by Rotge et al [23] revealed no volumetric differences for the whole brain, the intracranial region, the gray matter, the prefrontal cortex or the basal ganglia of OCD patients, but reduced volumes of the left ACC, the left and the right OFCs, and increased volumes of the left and the right thalami. In addition, the severity of OCD was determined to be correlated significantly with the effect sizes of the left and the right thalami.…”

Section: Key Brain Regionsmentioning

confidence: 97%

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Atmaca

2011

Neurosci. Bull.

View full text Add to dashboard Cite

Abstract:The notion that some special brain regions may be involved in the pathogenesis of obsessive-compulsive disorder (OCD) dates back to the beginning of the twentieth century. Structural neuroimaging studies in the past 2 decades have revealed important findings that facilitate understanding of OCD pathogenesis. Current knowledge based on functional and structural neuroimaging investigations largely emphasizes abnormalities in fronto-striatal-thalamic-cortical and orbitofronto-striato-thalamic circuits in the pathophysiology of OCD. However, these neuroimaging studies did not focus on refractory OCD. The present review mainly focused on structural neuroimaging performed in OCD, which had been ignored previously, and highlighted current evidence supporting that orbito-frontal cortex and thalamus are key brain regions, and that the hippocampus-amygdala complex is associated with refractoriness to the available treatment strategies.However, to fully reveal the neuroanatomy of refractoriness, longitudinal studies with larger samples are required.

show abstract

“…In a single case, the development of obsessivecompulsive symptoms after the diagnosis of MS was found to be associated with the emergence of a right parietal white matter multiple sclerosis plaque. 33 In primary OCD, morphometric alterations have been consistently found not only in the frontal lobe (dorsolateral, orbitofrontal, and anterior cingulate cortices) and the basal ganglia 34,35 but also in the supramarginal gyrus, 36 anterior superior temporal cortex, 25 hippocampus, and amygdala. 31 Some evidence of the role of the temporal lobe in the pathophysiology of OCD has been yielded by studies on OCD associated with neurologic disorders, particularly with epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Structural Brain MR Imaging Changes Associated with Obsessive-Compulsive Disorder in Patients with Multiple Sclerosis

Tinelli¹,

Francia²,

Quartuccio³

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:Psychiatric symptoms occur in approximately 30% of patients with MS. Such symptoms include OCD, which may interfere heavily with the patient's daily life. We hypothesized that the widespread involvement of both GM and WM, which characterizes MS, may be responsible for the occurrence of OCD when specific brain structures are affected. The aim of this study was to evaluate the relationship between GM and WM tissue damage and OCD in patients with MS.

show abstract

Meta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder

Cited by 245 publications

References 47 publications

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Structural Brain MR Imaging Changes Associated with Obsessive-Compulsive Disorder in Patients with Multiple Sclerosis

Contact Info

Product

Resources

About