2012
DOI: 10.1111/j.1365-2036.2012.05211.x
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Abstract: SUMMARY BackgroundThe decreasing efficacy of H. pylori eradication treatments over time makes the search for better regimens and adjuvant medications a priority.

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Cited by 172 publications
(168 citation statements)
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“…CYP2C19 genotypes can be determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis and divided into 3 groups in relation to PPI metabolism; rapid metabolizer (RM), intermediate metabolizer (IM) or poor metabolizer (PM). Genotype RM experience rapid clearance of PPI and generally has less effective than PM (Yamada et al, 2001;Furuta et al, 2001;Sugimoto et al, 2009;McNicholl et al, 2012). Among phenotypic RM and IM, higher dose of PPI or frequent dosing of PPI may require increasing efficacy of gastroprotective effect.…”
Section: Introductionmentioning
confidence: 99%
“…CYP2C19 genotypes can be determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis and divided into 3 groups in relation to PPI metabolism; rapid metabolizer (RM), intermediate metabolizer (IM) or poor metabolizer (PM). Genotype RM experience rapid clearance of PPI and generally has less effective than PM (Yamada et al, 2001;Furuta et al, 2001;Sugimoto et al, 2009;McNicholl et al, 2012). Among phenotypic RM and IM, higher dose of PPI or frequent dosing of PPI may require increasing efficacy of gastroprotective effect.…”
Section: Introductionmentioning
confidence: 99%
“…A meta-analysis showed that the cure rate of high-dose PPI was 583/711 (82 %) compared to 734/992 (74 %) with standard-dose PPI (RR 1.09; 95 % CI 1.01-1.17) [33]. In addition, a recent meta-analysis has shown that the maximal effect was seen in the studies comparing a high dose of the more potent second-generation PPIs [34]. A pooled analysis demonstrated the superiority of sequential therapy over 7-day triple therapy with an RR of 1.23 (95 % CI 1.19-1.27) [35].…”
Section: Eradication Regimenmentioning
confidence: 99%
“…Большинство инги-биторов протонной помпы, включая омепразол, лансо-празол и пантопразол, интенсивно метаболизируются в системе цитохрома CYP2С19 [2]. Однако эффективность эрадикации Helicobacter pylori с применением рабепразо-ла достоверно выше, что доказано результатами различ-ных метаанализов, в том числе современного метаанали-за по 35 исследованиям (5 998 человек) и мультицентро-вого исследования в Японии, в ходе которого тройную семидневную терапию, включающую рабепразол, приме-няли для эрадикации Helicobacter pylori у 3 162 человек и эффективность лечения составила 80,7% [3][4][5][6]. В опубли-кованном в 2017 г. европейском консенсусе Маастрихт-5 официально рекомендуется применять преимущественно рабепразол и эзомепразол в схемах эрадикации первой и второй линии [7].…”
Section: рабепразол и эрадикация Helicobacter Pyloriunclassified