Meta-Analysis Comparing Frequency of Overweight Versus Normal Weight in Patients With New-Onset Heart Failure

Krittanawong, Chayakrit; Tunhasiriwet, Anusith; Wang, Zhen; Zhang, Hong Ju; Prokop, Larry J.; Chirapongsathorn, Sakkarin; Sun, Tao; Kitai, Takeshi; Tang, W.H. Wilson

doi:10.1016/j.amjcard.2017.12.021

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Corroborating with the findings of the previous study, the systematic review and meta-analysis conducted by Krittanawong et al, (2018), noted that being overweight increased the incidence of HF by 1.33 (95% CI 1.16 to 1.52; p <001, I2 = 83.6%) when compared to the normal group, representing an increase of about 33%. However, the increase in incidence risk differs among patients, with female patients being more impaired with a risk of 1.23 (95% CI 1.13 to 1.34; p <001, I2 = 0%), i.e., a 23% increased risk, while male patients showed no significant association (1.07, 95% CI 0.69 to 1.64; p = 0.772, I2 = 0%).…”

Section: Discussionsupporting

confidence: 78%

Obesity as a risk factor for heart failure: overview of systematic reviews

Bezerra

Paiva

Silva

et al. 2022

RSD

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The overweight and population with obesity has an increased risk of mortality from HF. However, some studies point to the existence of an "obesity paradox" where there could be a protective effect on the relative risk of death by HF in these populations with high BMI. In this way, the present study aimed to investigate obesity as a risk factor for heart failure. For this, an overview of systematic reviews was performed by selecting articles from the following databases: "Pubmed", "Scopus" and "SciElo”. A total of 615 articles were found from this initial search, leaving 59 articles for full-text reading, of which 22 articles were included for data extraction using the predefined inclusion criteria. From these 22 studies 73% were meta-analysis and 64% of the studies are of high methodological quality according to AMSTAR-2. Overweight and obesity have demonstrated a close relationship with the onset and increase of mortality by HF, studies have even been found that point to a gene interference in this relationship. In studies reporting on the obesity paradox, the results pointed to a momentary protection from mortality risk.

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Section: Discussionsupporting

confidence: 78%

Obesity as a risk factor for heart failure: overview of systematic reviews

Bezerra

Paiva

Silva

et al. 2022

RSD

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“…Obesity is a contributor to increased morbidity and mortality, primarily from CVD. Furthermore, obesity contributes to the development of heart failure by 33% in a BMI-dependent increment [4]. Excess body weight and accumulated abdominal fat result in cardiac hemodynamic alterations.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet

Men

Hui

Guan

et al. 2020

Genes

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Obesity is associated with an increased risk of developing cardiovascular disease (CVD), with limited alterations in cardiac genomic characteristics known. Cardiac transcriptome analysis was conducted to profile gene signatures in high-fat diet (HFD)-induced obese mice. A total of 184 differentially expressed genes (DEGs) were identified between groups. Based on the gene ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs, the critical role of closely interlocked glucose metabolism was determined in HFD-induced cardiac remodeling DEGs, including Nr4a1, Fgf21, Slc2a3, Pck1, Gck, Hmgcs2, and Bpgm. Subsequently, the expression levels of these DEGs were evaluated in both the myocardium and palmitic acid (PA)-stimulated H9c2 cardiomyocytes using qPCR. Nr4a1 was highlighted according to its overexpression resulting from the HFD. Additionally, inhibition of Nr4a1 by siRNA reversed the PA-induced altered expression of glucose metabolism-related DEGs and hexokinase 2 (HK2), the rate-limiting enzyme in glycolysis, thus indicating that Nr4a1 could modulate glucose metabolism homeostasis by regulating the expression of key enzymes in glycolysis, which may subsequently influence cardiac function in obesity. Overall, we provide a comprehensive understanding of the myocardium transcript molecular framework influenced by HFD and propose Nr4a1 as a key glucose metabolism target in obesity-induced CVD.

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“…Coronary artery diseases (CAD) such as ischemia reperfusion injury (I/R) and acute myocardial infarction (AMI) are the primary forms of CVD that account for the majority of the deaths. Apart from this, additional comorbid factors like diabetes [ 3 , 4 ], obesity [ 5 ], inflammation [ 6 ], and atherosclerosis [ 7 ] escalate the complication associated with heart disease and increase the incidence of death. The underlying mechanisms involved in cardiovascular complication are complex and multifactorial.…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular Diseases

Samidurai

Kukreja

Das

2018

Oxidative Medicine and Cellular Longevity

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Mechanistic/mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase of the phosphoinositide 3-kinase- (PI3K-) related kinase family, elicits a vital role in diverse cellular processes, including cellular growth, proliferation, survival, protein synthesis, autophagy, and metabolism. In the cardiovascular system, the mTOR signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of both physiological and pathological processes. MicroRNAs (miRs), a class of short noncoding RNA, are an emerging intricate posttranscriptional modulator of critical gene expression for the development and maintenance of homeostasis across a wide array of tissues, including the cardiovascular system. Over the last decade, numerous studies have revealed an interplay between miRNAs and the mTOR signaling circuit in the different cardiovascular pathophysiology, like myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation, and atherosclerosis. In this review, we provide a comprehensive state of the current knowledge regarding the mechanisms of interactions between the mTOR signaling pathway and miRs. We have also highlighted the latest advances on mTOR-targeted therapy in clinical trials and the new perspective therapeutic strategies with mTOR-targeting miRs in cardiovascular diseases.

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Meta-Analysis Comparing Frequency of Overweight Versus Normal Weight in Patients With New-Onset Heart Failure

Cited by 6 publications

References 43 publications

Obesity as a risk factor for heart failure: overview of systematic reviews

Obesity as a risk factor for heart failure: overview of systematic reviews

Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet

Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular Diseases

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