Mesothelioma Mortality in Brazil, 1980–2003

Pedra, Francisco; Tambellini, Anamaria Testa; Pereira, Basílio de Bragança; Costa, Ana Carolina Carioca da; Castro, Hermano Albuquerque de

doi:10.1179/oeh.2008.14.3.170

Cited by 29 publications

(41 citation statements)

References 14 publications

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“…This finding suggests that the peak has already passed (Price and Ware 2004). On the other hand, the peak for many South American countries (e.g., Brazil) is expected to occur in the 2010s or 2020s, due to the later ban of asbestos use (Nishikawa et al 2008; Pedra et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past?

Tse

Goggins

et al. 2010

Environ Health Perspect

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BackgroundBecause of the long latent period of asbestos-related mesothelioma, investigators suggest that the high incidence of this disease will continue in the coming decades.ObjectivesWe describe the time trends of mesothelioma incidence and its relationship to historical consumption of asbestos in Hong Kong and project future trends of mesothelioma incidence.MethodsWe obtained local annual consumption of total asbestos for 1960–2006 (converted to kilograms per person per year). Age-standardized incidence rates (ASIRs) of mesothelioma were computed and depicted on graphs using the centered moving average method. Indirectly standardized rates were regressed on a transformation of consumption data that assumed that the latency between asbestos exposure and mesothelioma diagnosis followed a normal distribution with a mean ± SD of 42 ± 10.5 years.ResultsASIRs for males started to increase substantially in 1994 and were highest in 2004; for females, ASIRs climbed in the 1980s and in the early 1990s but have fluctuated without obvious trends in recent years. The highest asbestos consumption level in Hong Kong was in 1960–1963 and then decreased sharply afterward. Using past asbestos consumption patterns, we predict that the mesothelioma incidence rate for males will peak in 2009, with the number of cases peaking in 2014, and then slowly decline in the coming decades.ConclusionsHong Kong experienced an epidemic of mesothelioma from 2000 to 2006 that corresponded with the peak of local asbestos consumption in the early 1960s assuming an average latent period of 42 years. The incidence is anticipated to decline in the coming decades but may not decrease back to the background risk level (the risk unrelated to asbestos exposure).

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Section: Discussionmentioning

confidence: 99%

Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past?

Tse

Goggins

et al. 2010

Environ Health Perspect

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“…In Brazil, there is an impressive lack of studies and an underreporting of MPM cases, making it difficult to make public health decisions [6]. Pedra et al [7] studied MPM mortality in Brazil, from 1980 to 2003, and found the death frequency increased from an average of 68.4 per year in the 1980s to 110 per year in the following decade, and 157 per year in 2000–2003.…”

Section: Introductionmentioning

confidence: 99%

Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas

et al. 2020

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Background: Malignant pleural mesothelioma (MPM) is a highly lethal disease comprising a heterogeneous group of tumors with challenging to predict biological behavior. The diagnosis is complex, and the histologic classification includes 2 major subtypes of MPM: epithelioid (∼60% of cases) and sarcomatous (∼20%). Its identification depends upon pathological investigation supported by clinical and radiological evidence and more recently ancillary molecular testing. Treatment options are currently limited, with no known targeted therapies available. Objectives: To elucidate the mutation profile of driver tumor suppressor and oncogenic genes in a cohort of Brazilian patients. Methods: We sequenced 16 driver genes in a series of 43 Brazilian malignant mesothelioma (MM) patients from 3 distinct Brazilian centers. Genomic DNA was extracted from formalin-fixed paraffin-embedded tumor tissue blocks, and the TERT promoter region was amplified by PCR followed by direct capillary sequencing. The Illumina TruSight Tumor 15 was used to evaluate 250 amplicons from 15 genes associated with solid tumors (AKT1, GNA11, NRAS, BRAF, GNAQ, PDGFRA, EGFR, KIT, PIK3CA, ERBB2, KRAS, RET, FOXL2, MET,and TP53). Library preparation with the TruSight Tumor 15 was performed before sequencing at the MiSeq platform. Data analysis was performed using Sophia DDM software. Results: Out of 43 MPM patients, 38 (88.4%) were epithelioid subtype and 5 (11.6%) were sarcomatoid histotype. Asbestos exposure was present in 15 (39.5%) patients with epithelioid MPM and 3 (60%) patients with sarcomatoid MPM. We found a TERT promoter mutation in 11.6% of MM, and the c.-146C>T mutation was the most common event. The next-generation sequencing was successful in 33 cases. A total of 18 samples showed at least 1 pathogenic, with a median of 1.8 variants, ranging from 1 to 6. The most mutated genes were TP53 and ERBB2 with 7 variants each, followed by NRAS BRAF, PI3KCA, EGFR and PDGFRA with 2 variants each. KIT, AKT1, and FOXL2 genes exhibited 1 variant each. Interestingly, 2 variants observed in the PDGFRA gene are classic imatinib-sensitive therapy. Conclusions: We concluded that Brazilian MPM harbor mutation in classic tumor suppressor and oncogenic genes, which might help in the guidance of personalized treatment of MPM.

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“…32 Pedra et al described 2,414 mesothelioma deaths in the period 1996 to 2003 in Brazil, using a combination of International Classification of Diseases 9 (ICD-9) codes 163 (malignant neoplasm of pleura) for 1980–1995 and ICD-I0 codes C45 (mesothelioma) and C38.4 (malignant neoplasm of pleura) for 1996–2003. 33 China A law with the purpose of preventing, controlling, and eliminating occupational disease hazards went into effect in China, in May 1, 2002. 34 It details all provisions for prevention and control, diagnosis, supervision and inspection, and legal responsibilities regarding occupational diseases.…”

Section: Surveillance For Ords In Low- and Middle-income Countriesmentioning

confidence: 99%

Section: Surveillance For Ords In Low- and Middle-income Countriesmentioning

confidence: 99%

Surveillance for Occupational Respiratory Diseases in Developing Countries

Antao

Pinheiro

2015

Semin Respir Crit Care Med

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The burden of chronic diseases, including occupational respiratory diseases (ORDs), is increasing worldwide. Nevertheless, epidemiological data on these conditions are scarce in most countries. Therefore, it is important to conduct surveillance to monitor ORDs, particularly in developing countries, where the working population is especially vulnerable and the health system infrastructure is usually weak. This article provides a general framework for the implementation of ORD surveillance in developing countries. The main objectives of surveillance are to describe incidence and prevalence of ORDs, as well as to identify sentinel events and new associations between occupational exposures and health outcomes. Diseases with high morbidity and mortality and those in which early diagnosis with standardized tests are available are especially suitable for surveillance activities. Simple strategies, preferably using existing resources and technology, are the best option for surveillance in developing countries. This article offers examples of specific surveillance systems that are in place in Brazil, China, Cuba, India, and South Africa.

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Mesothelioma Mortality in Brazil, 1980–2003

Cited by 29 publications

References 14 publications

Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past?

Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past?

Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas

Surveillance for Occupational Respiratory Diseases in Developing Countries

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