Mesothelioma in Familial Mediterranean Fever With Colchicine Intolerance: A Case Report and Literature Review

Talerico, Rosa; Cardillo, Carmine; Vito, Francesco De; Schinzari, Francesca; Soldato, Manuel; Giustiniani, Maria Cristina; Verrecchia, Elena; Manna, Raffaele

doi:10.3389/fimmu.2020.00889

Cited by 9 publications

(10 citation statements)

References 36 publications

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“…One thousand two hundred eighty-one patients were identified in 112 articles, including 75 case reports and case series ( 11 , 11 , 17 – 88 ), 31 cohort studies ( 10 , 89 – 119 ), four phase II trials ( 99 , 120 – 122 ), and two randomized placebo-controlled trials ( 9 , 12 ). Seven hundred ninety patients (61.7%) were diagnosed with FMF, 265 (20.7%) with MKD, and 226 (17.6%) with TRAPS.…”

Section: Resultsmentioning

confidence: 99%

Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review

et al. 2021

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BackgroundInterleukin (IL)-1 inhibitors represent the main treatment in patients with colchicine-resistant/intolerant familial Mediterranean fever (crFMF), mevalonate kinase deficiency (MKD), and tumor necrosis factor receptor-associated periodic syndrome (TRAPS). However, the reasons for the use of IL-1 inhibitors in these diseases are still not completely clarified.ObjectiveIdentify real-life situations that led to initiating anakinra or canakinumab treatment in hereditary recurrent fevers (HRFs), combining data from an international registry and an up-to-date literature review.Patients and MethodsData were extracted from the JIRcohort, in which clinical information (demographic data, treatment, disease activity, and quality of life) on patients with FMF, MKD, and TRAPS was retrospectively collected. A literature search was conducted using Medline, EMBASE, and Cochrane databases.ResultsComplete data of 93 patients with HRF (53.8% FMF, 31.2% MKD, and 15.1% TRAPS) were analyzed. Data from both the registry and the literature review confirmed that the main reasons for use of IL-1 blockers were the following: failure of previous treatment (n = 57, 61.3% and n = 964, 75.3%, respectively), persistence of disease activity with frequent attacks (n = 44, 47.3% and n = 1,023, 79.9%) and/or uncontrolled inflammatory syndrome (n = 46, 49.5% and n = 398, 31.1%), severe disease complication or associated comorbidities (n = 38, 40.9% and n = 390, 30.4%), and worsening of patients’ quality of life (n = 36, 38.7% and n = 100, 7,8%). No reasons were specified for 12 (16.4%) JIRcohort patients and 154 (12%) patients in the literature.ConclusionIn the absence of standardized indications for IL-1 inhibitors in crFMF, MKD, and TRAPS, these results could serve as a basis for developing a treat-to-target strategy that would help clinicians codify the therapeutic escalation with IL-1 inhibitors.

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Section: Resultsmentioning

confidence: 99%

Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review

et al. 2021

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“…The patient had been prescribed anakinra due to colchicine intolerance and to prevent recurrent FMF attacks, but unfortunately, the patient died due to sepsis before the effects of anakinra treatment could be evaluated. 29 A history of abdominal surgery also increases the risk of ASBO, so avoiding unnecessary surgical interventions is advisable. 13,14,21 Autoinflammatory diseases other than FMF can also lead to ASBO due to recurrent serosal inflammation, such as hyperimmunoglobulin D syndrome (HIDS).…”

Section: Discussionmentioning

confidence: 99%

“…However, Talerico et al 29 described a 65‐year‐old patient diagnosed with peritoneal mesothelioma due to repeated peritoneal inflammation of FMF. The patient had been prescribed anakinra due to colchicine intolerance and to prevent recurrent FMF attacks, but unfortunately, the patient died due to sepsis before the effects of anakinra treatment could be evaluated 29 . A history of abdominal surgery also increases the risk of ASBO, so avoiding unnecessary surgical interventions is advisable 13,14,21 …”

Section: Discussionmentioning

confidence: 99%

Adhesive small‐bowel obstruction as a challenging complication of familial Mediterranean fever: A case‐based review

Küçükali,

Gezgin Yıldırım,

Esmeray Şenol

et al. 2023

Int J of Rheum Dis

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Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disorder, characterized by recurrent and self‐limiting episodes of fever and serosal inflammation. Recurrent serositis may rarely lead to the formation of adhesions in the peritoneum, which may result in mechanical bowel obstruction. The symptoms, such as abdominal pain and vomiting, may mimic typical FMF attacks, resulting in misdiagnosis and severe morbidity, including strangulation and intestinal necrosis. Physicians are generally aware of other complications associated with FMF but reports on peritoneal adhesions and intestinal obstruction in English‐language literature are inadequate to increase clinicians' awareness. Therefore, it is crucial to meticulously evaluate FMF patients presenting with abdominal pain and ileus because these symptoms could be due to adhesive small‐bowel obstruction (ASBO). Furthermore, patients presenting with ASBO without a history of abdominal surgery should also be thoroughly evaluated, especially as it could be an initial presentation for an autoinflammatory disease. Herein, we present a pediatric case of FMF with the M694V homozygous mutation, complicated by ASBO while under colchicine treatment. Additionally, we provide a comprehensive review of the available literature on ASBO in FMF.

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“…In human, a patient of Familial Mediterranean Fever (FMF), who carries the mutation of NALP3 suppressor Pyrins and suffers from recurrent bouts of fever and serosal inflammation, is presumed to develop MM with intolerance or resistance to colchicine or IL-1 inhibition. 115 On the other hand, decreased incidence and prolonged development of crocidolite-induced MM were not observed in Nlrp3 KO mice. 116 These difference in Asc and Nlrp3 in murine crocidolite-induced mesothelial carcinogenesis may be explained that Asc forms an inflammasome complex with Nlrc4 or Nlrp6 or Aim2 and generates inflammatory reaction.…”

Section: Future Perspectivementioning

confidence: 97%

Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species

Okazaki

2021

Pathology International

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Asbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos-induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of MM is estimated to occur after a latent period of 30-40 years from initial exposure to asbestos fibers; thus, the continuous increase in MM is a concern. To explore the molecular mechanisms of MM using animal models, iron saccharate with iron chelatorinduced sarcomatoid mesothelioma (SM) revealed hallmarks of homozygous deletion of Cdkn2a/2b by aCGH and microRNA-199/214 by expression microarray. Oral treatment of iron chelation by deferasirox decreased the rate of high-grade SM. Moreover, phlebotomy delayed MM development in crocidolite-induced MM in rats. In Divalent metal transporter 1 (Dmt1) transgenic mice, MM development was delayed because of low reactive oxygen species (ROS) production. These results indicate the importance of iron and ROS in mesothelial carcinogenesis. The aims of this review focus on the pathogenesis of elongated mineral particles (EMPs), including asbestos fibers and multiwalled carbon nanotubes (MWCNTs) that share similar rod-like shapes in addition to the molecular mechanisms of MM development.

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Mesothelioma in Familial Mediterranean Fever With Colchicine Intolerance: A Case Report and Literature Review

Cited by 9 publications

References 36 publications

Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review

Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review

Adhesive small‐bowel obstruction as a challenging complication of familial Mediterranean fever: A case‐based review

Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species

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