Mesoporous titanium dioxide coating for metallic implants

Abstract

A bioactive mesoporous titanium dioxide (MT) coating for surface drug delivery has been investigated to develop a multifunctional implant coating, offering quick bone bonding and biological stability. An evaporation induced self-assembly (EISA) method was used to prepare a mesoporous titanium dioxide coating of the anatase phase with BET surface area of 172 m(2)/g and average pore diameter of 4.3 nm. Adhesion tests using the scratch method and an in situ screw-in/screw-out technique confirm that the MT coating bonds tightly with the metallic substrate, even after removal from bone. Because of its high surface area, the bioactivity of the MT coating is much better than that of a dense TiO(2) coating of the same composition. Quick formation of hydroxyapatite (HA) in vitro can be related to enhance bonding with bone. The uptake of antibiotics by the MT coating reached 13.4 mg/cm(3) within a 24 h loading process. A sustained release behavior has been obtained with a weak initial burst. By using Cephalothin as a model drug, drug loaded MT coating exhibits a sufficient antibacterial effect on the material surface, and within millimeters from material surface, against E.coli. Additionally, the coated and drug loaded surfaces showed no cytotoxic effect on cell cultures of the osteoblastic cell line MG-63. In conclusion, this study describes a novel, biocompatiblemesoporous implant coating, which has the ability to induce HA formation and could be used as a surface drug-delivery system.

Osteogenic potential of human adipose-derived stromal cells on 3-dimensional mesoporous TiO2 coating with magnesium impregnation

“…In a previous study, we analyzed the cellular response of osteoblasts (human fetal osteoblasts) to mesoporous TiO 2 coatings generated by the evaporation-induced self-assembly method (EISA) [25,26] and chemically modified with magnesium [27]. We demonstrated that human fetal osteoblasts (hFOB) adhesion was significantly enhanced by the presence of the mesopores.…”

The antimicrobial activity of nanoparticles: present situation and prospects for the future

“…The application of a titanium oxide coating on implants is based on pore morphology, with calcium, silicon, phosphorus, and silver particle enrichment. 62 The coating inhibits the adhesion and growth of bacteria such as Streptococcus mutans, Streptococcus epidermis, and E. coli and prevents the occurrence of inflammation around the implants. Preliminary biological characterization also indicated that a nanocoating can improve the adhesion and proliferation of osteoblast cell lines.…”

Surface Modification of Titanium and its Alloys for Biomedical Application

“…Fig. 1 Films generated by sol-gel methods in (A) [15] and (B) [16] Oxidation that coats a bioactive TiO 2 layer on the Ti substrate is a promising approach to medical applications. With a mesoporous bioactive TiO 2 layer, the coating improves the accumulation of Ca and P, which subsequently transfer to hydroxyapatite [17,18].…”