Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

Abstract

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuliresponsive drug delivery nanodevices.

Mesoporous silica nanoparticles SBA-15 loaded with emodin upregulate the antioxidative defense of Euproctis chrysorrhoea (L.) larvae

“…The formation of monoglucuronides in microsomes represents the second phase of biotransformation of anthraquinones (and EO) in vivo, and is the main metabolic pathway for its elimination (Wu et al, 2014). A likely reason for the greater efficiency of SBA-15|EO lies in the properties of mesoporous silica, a ceramic matrix that efficiently protects entrapped molecules against degradation or denaturation by enzymes, pH, temperature, or light (Vallet-Regí, 2012;Krajnović et al, 2017). Also, it is possible that substances loaded onto a mesoporous material such as the SBA-15 carrier enter the cells more easily, probably by macropinocytosis (unpublished data).…”

“…Mesoporous silica nanoparticles and other silica-based materials, notably SBA-15, are considered as exceptional particles due to their high pore volume, surface area, high loading capacities, controlled delivery, efficient cellular uptake (Vallet-Regí, 2012), and, importantly, their nontoxic behavior in cells, even at high concentrations of up to 1 mg mL -1 (Bensing et al, 2016). Given the above information regarding the molecular mechanisms that underlie EO actions, we assumed that EO could act as a prooxidant when given with an artificial diet to 6th instar E. chrysorrhoea larvae.…”

Tailoring hierarchical meso–macroporous 3D scaffolds: from nano to macro

“…Therefore, the single-step sol-gel route synthesis in presence of a surfactant (F127) as mesostructure directing agent and a biomacromolecular polymer (methylcellulose) as macrostructure template, followed by RP technique, allows the formation of the hierarchical interconnected 3D scaffolds exhibiting different scales of porosity: (i) highly ordered mesopores with diameters of ca.10 nm that may act as local controlled delivery systems of biologically active molecules, and allow better supply nutrient diffusion; [33][34][35] (ii) interconnected macropores with diameters in the 1-80 µm, and (iii) ultra-large macropores of ca. 500 µm, that may provide the opportunities for cell colonization.…”

Effects of 3D nanocomposite bioceramic scaffolds on the immune response

“…[27][28][29] Furthermore, the mesoporous arrangement could lead an added value as controlled delivery systems of biologically active molecules. 30,31 With the aim of evaluating the in vitro degradation of MGHA 3D scaffolds, the surface changes and the evolution of their macroporous structure after different incubation times in culture medium have been studied by SEM (Fig. 2).…”