Mesoporous silica nanoparticles: Synthesis, pharmaceutical applications, biodistribution, and biosafety assessment

Farjadian, Fatemeh; Mohammadi-Samani, Soliman; Hosseini, Majid

doi:10.1016/j.cej.2018.11.156

Cited by 181 publications

(126 citation statements)

References 271 publications

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“…To evaluate antibacterial efficiency, an aqueous solution (5 ml) of IL-Met-Ag with various concentrations (1,3,5,6,7,10,12,14,20,50,100,200, 300 and 400 μg/ml) were prepared in small vials. Then sodium alginate (0.03 g) was included in the solution, and the mixture was stirred at room temperature.…”

Section: Disc Diffusion Testmentioning

confidence: 99%

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Farjadian

Akbarizadeh

Tayebi

2020

Heliyon

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In this study, a new type of silver nanoparticles capped with metronidazolium based ionic liquid is synthesized. By this aim, metronidazole is altered to ionic-liquid type structure with citrate counter ion as reducing agent. The produced reducing agent was characterized using 1 HNMR and 13 CNMR and FT-IR. The capability of metronidazolium-based reducing agent in formation and capping silver nanoparticles was examined in a chemical reaction. More specifically, synthesized silver nanoparticles were synthesized and capped with metronidazoliumcitrate based ionic liquid, while the formation of particles in 48 h was monitored by UV-Vis spectroscopy. Fourier transform infrared spectroscopy showed the presence of capping agents around silver nanoparticles. The amount of metronidazolium and citrate as capping agents was determined by thermal gravimetric analysis. The prepared crystalline structure of silver nanoparticles was proved by X-ray diffraction spectroscopy. PSA analysis and TEM was performed to determine the size of particles. The synthesized silver nanoparticle has the potential to be used as an antibacterial agent in preparation of wound dressing with extra capability and efficacy in aerobic and anaerobic bacterium. In this regard, the antibacterial efficacy of discs from different concentration of silver nanoparticles in calcium alginate medium were evaluated in Gram-negative and Gram-positive bacterium.

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Section: Disc Diffusion Testmentioning

confidence: 99%

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Farjadian

Akbarizadeh

Tayebi

2020

Heliyon

Self Cite

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“…Considering the aforementioned, MSNs are very attractive as nanocarriers/nanotherapeutics because their interesting properties such as chemical and physical stabilities, size, morphology, surface and pores structures can be easily modulated to achieve good biological behavior and also effective drug loading and delivery at the desired site, comprising efficient nanoplatforms in most of pre-clinical assays. Internal, external or multi stimuli-responsive MSNs controlled drug delivery systems have been designed as smart nanoarchitectures that control pharmacokinetics parameters and emphasize the amazing properties of MSNs, stimulating researches towards their application in clinical trials (12,160,161).…”

Section: Clinical Translation Challenges and Future Outlookmentioning

confidence: 99%

“…Up to now, preclinical assays related to MSNs were successfully performed whereas no MSNs have been described in clinical trials. Authors (160) suggested that the clinical translation has failed due to the large physiological distinction between small animals and humans, indicating that animal models are not the better indication for further nanostructures success in humans. In addition, authors suggest that rather than prolonged xenografting experiments (in cancer treatment), positive animal toxicological results could allow to start phase 1 of clinical trials.…”

Section: Clinical Translation Challenges and Future Outlookmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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“…Ethylene groups on the surface of the MSNs could also reduce the hemolysis. 102 4.2.3. Surface roughness.…”

Section: Particle Morphology and Surface Modicationmentioning

confidence: 99%

Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

et al. 2019

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Mesoporous silica nanoparticles: Synthesis, pharmaceutical applications, biodistribution, and biosafety assessment

Cited by 181 publications

References 271 publications

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

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