Mesoporous Silica Nanoparticles Rescue H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-induced Inhibition of Cardiac Differentiation

Ren, Mingming; Wang, Tao; Huang, Lei; Ye, Xiaoqiang; Han, Zhen

doi:10.1247/csf.18008

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…12 There are few published studies demonstrating effects of any NPs on cardiomyocytes. In addition to cytotoxicity, reduced contraction amplitudes (with TiO 2 -NPs 13 ), enhanced beating properties (with mesoporous SiO 2 -NPs 14 ), interference with ion channels (with Pt-NPs 15 ), and increased Ca 2þ spikes and local Ca 2þ flux (chitosan NPs 16 ) have been reported. The 2016 overview devoted specially to NPs that cardiotoxicity considers such NP species as zinc, titanium, silver, carbon, silica, and iron oxide but does not mention lead or cadmium in any chemical form.…”

Section: Introductionmentioning

confidence: 99%

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

et al. 2020

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Spherical nanoparticles (NPs) of cadmium and lead sulfides (diameter 37 ± 5 and 24 ± 4 nm, respectively) have been found to be cytotoxic for HL-1 cardiomyocytes as evidenced by decrease in adenosine triphosphate–dependent luminescence. Cadmium sulfide (CdS)-NPs were discovered to produce a much greater cytotoxic impact than lead sulphide (PbS)-NP. Given the same dose range, CdS-NP reduced the number of calcium spikes. A similar effect was observed for small doses of PbS-NP. In addition to cell hypertrophy under the impact of certain doses of CdS-NP and PbS-NP, doses causing cardiomyocyte size reduction were identified. For these 3 outcomes, we obtained both monotonic “dose–response” functions (well approximated by the hyperbolic function) and different variants of non-monotonic ones for which we found adequate mathematical expressions by modifying certain models of hormesis available in the literature. Data analysis using a response surface linear model with a cross-term provided new support to the previously established postulate that a diversity of types of joint action characteristic of one and the same pair of damaging agents is one of the important assertions of the general theory of combined toxicity.

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Section: Introductionmentioning

confidence: 99%

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

et al. 2020

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“…MSNs are widely used in in vivo therapeutical applications, due to their improved biocompatibility, specificity, and low toxicity. Although MSNs have been shown to relieve H 2 O 2 ‐elicited intracellular oxidative stress in a cardiac model, [ 230 ] the exact mechanism of their action on neuronal models is yet to be investigated. With their exceptionally large surface area resulting from increased porosity, MSNs also provide a great platform for drug encapsulation and surface functionalization.…”

Section: Nanocarrier‐based Delivery Of Antioxidantsmentioning

confidence: 99%

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Eleftheriadou

Kesidou

Moura

et al. 2020

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dementia, which result from chronic and progressive loss of neuronal function. In view of an ageing population, disorders of the brain are likely to establish the principal economic challenge in the future of healthcare. [1] The total cost of dementia to society in the UK alone is £26.3 billion, and this is expected to double over the next 30 years given that prevalence is projected to rise by 40% in the coming decade alone. [2] Among NDs, significant attention has been paid to Alzheimer's disease (AD) and Parkinson's disease (PD) given their severe complications and economic burdens. AD, which accounts for the vast majority of age-related dementia, is a progressive disorder that is characterized by gradual neuronal loss and accumulation of proteins, namely extracellular amyloid-β plaques and intracellular tau tangles. [3] PD is a progressive ND resulting from the loss of specific dopaminergic (DA) neurons in the substantia nigra pars compacta and reduced DA levels in the nigrostriatal DA pathway in the brain. [4,5] Despite significant progress in the management of NDs over the recent years, the early diagnostic and treatment options remain limited. Patients currently suffering from NDs have no available disease-modifying treatments. Instead, patients are offered a therapeutic plan focused on the management of their ND symptoms, whilst concurrently attempting to reduce the adverse effects associated with the medications used. The systemic delivery of drugs to the central nervous system (CNS) is complex due to their poor delivery to the brain, extensive firstpass metabolism which reduces their half-life, and the sideeffects resulting from the drug acting on non-target peripheral tissues. [6] The mainstay of current treatments for NDs is typically through oral administration. For PD medications include L-dopa, carbidopa (peripheral inhibitor of L-dopa into DOPA), dopaminergic agonists, Entacapone (Catechol-O-methyl transferase inhibitor), monoamine oxidase-B inhibitors, amongst others. Other routes of drug administration exist such as subcutaneous injection of dopaminergic agonists. Interestingly, deep brain stimulation has also been offered to those patients resistant to medical therapy but again associated with significant adverse effects. L-Dopa, which is considered the most effective treatment in the short-term for PD, [7] is related to longterm wearing-off phenomena, dyskinesias, and neuropsychiatric disorders. [8] Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeutic approaches have been suggested so far to improve the endogenous defense against oxidative stress and its harmful effects. Among such approaches, the use o...

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“…Previous studies have shown that elevated ROS could reduce the proliferation and pluripotency of hPSCs [ 14 , 15 ]. Similarly, treatment with hydrogen peroxide (H 2 O 2 ) increased cellular ROS and impaired cardiac differentiation of hESC-derived embryoid bodies (EBs) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress

Hang,

Moawad,

Lin

et al. 2024

J Nanobiotechnol

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Background Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, and regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), the effects of current antioxidants targeting excessive ROS are limited. Nanotechnology is a powerful tool to develop antioxidants with improved selectivity, solubility, and bioavailability to prevent or treat various diseases related to oxidative stress. Cerium oxide nanozymes (CeONZs) can effectively scavenge excessive ROS by mimicking the activity of endogenous antioxidant enzymes. This study aimed to assess the nanotoxicity of CeONZs and their potential antioxidant benefits in stressed human embryonic stem cells (hESCs) and their derived cardiomyocytes (hESC-CMs). Results CeONZs demonstrated reliable nanosafety and biocompatibility in hESCs and hESC-CMs within a broad range of concentrations. CeONZs exhibited protective effects on the cell viability of hESCs and hESC-CMs by alleviating excessive ROS-induced oxidative stress. Moreover, CeONZs protected hESC-CMs from doxorubicin (DOX)-induced cardiotoxicity and partially ameliorated the insults from DOX in neonatal rat cardiomyocytes (NRCMs). Furthermore, during hESCs culture, CeONZs were found to reduce ROS, decrease apoptosis, and enhance cell survival without affecting their self-renewal and differentiation potential. Conclusions CeONZs displayed good safety and biocompatibility, as well as enhanced the cell viability of hESCs and hESC-CMs by shielding them from oxidative damage. These promising results suggest that CeONZs may be crucial, as a safe nanoantioxidant, to potentially improve the therapeutic efficacy of CVDs and be incorporated into regenerative medicine. Graphical Abstract

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Mesoporous Silica Nanoparticles Rescue H<sub>2</sub>O<sub>2</sub>-induced Inhibition of Cardiac Differentiation

Cited by 3 publications

References 40 publications

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress

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