Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant

Vikulina, Anna S.; Webster, Joseph B.; Voronin, Denis V.; Иванов, Е. В.; Fakhrullin, Rawil; Винокуров, В. А.; Volodkin, Dmitry

doi:10.1016/j.matdes.2020.109220

Cited by 43 publications

(48 citation statements)

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“…Nanoparticles may be divided into two main types, based on their nature, i.e., organic [ 17 , 18 ] and inorganic [ 19 , 20 ] ones. Inorganic particles and structures include, for example, nanosized particles of calcium or strontium carbonate [ 21 , 22 , 23 , 24 ], gold and silver [ 25 , 26 , 27 ] and iron oxide [ 28 ], as well as quantum dots and carbon nanotubes [ 29 , 30 ], and others. In turn, hybrid nanomaterials, i.e., materials composed of both inorganic and organic components, provide the ability to tune the properties of the hybrid material systematically and are therefore very promising for imaging and therapeutic applications [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

et al. 2021

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In the present work, we have successfully prepared and characterized novel nanocomposite material exhibiting temperature-dependent surface wettability changes, based on grafted brush coatings of non-fouling poly(di(ethylene glycol)methyl ether methacrylate) (POEGMA) with the embedded CaCO3 nanoparticles. Grafted polymer brushes attached to the glass surface were prepared in a three-step process using atom transfer radical polymerization (ATRP). Subsequently, uniform CaCO3 nanoparticles (NPs) embedded in POEGMA-grafted brush coatings were synthesized using biomineralized precipitation from solutions of CaCl2 and Na2CO3. An impact of the low concentration of the embedded CaCO3 NPs on cell adhesion and growth depends strongly on the type of studied cell line: keratinocytes (HaCaT), melanoma (WM35) and osteoblastic (MC3T3-e1). Based on the temperature-responsive properties of grafted brush coatings and CaCO3 NPs acting as biologically active substrate, we hope that our research will lead to a new platform for tissue engineering with modified growth of the cells due to the release of biologically active substances from CaCO3 NPs and the ability to detach the cells in a controlled manner using temperature-induced changes of the brush.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

et al. 2021

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“…Among others, our recent results demonstrated the approach to fabricate nanocrystals that have a similar internal structure as large microsized CaCO 3 . 43 This opens avenues for the fabrication of mesoporous pNIPAM nanogels analogous to that of MM-gels. Potentially, such nanoformulations could be utilized for other administration routes such as intravenous injections.…”

Section: Discussionmentioning

confidence: 97%

Cooling-Triggered Release from Mesoporous Poly(N-isopropylacrylamide) Microgels at Physiological Conditions

Vikulina

Feoktistova

Балабушевич

et al. 2020

ACS Appl. Mater. Interfaces

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Poly( N -isopropylacrylamide) (pNIPAM) hydrogels have broad potential applications as drug delivery vehicles because of their thermoresponsive behavior. pNIPAM loading/release performances are directly affected by the gel network structure. Therefore, there is a need with the approaches for accurate design of 3D pNIPAM assemblies with the structure ordered at the nanoscale. This study demonstrates size-selective spontaneous loading of macromolecules (dextrans 10−500 kDa) into pNIPAM microgels by microgel heating from 22 to 35 °C (microgels collapse and trap dextrans) followed by the dextran release upon further cooling down to 22 °C (microgels swell back) . This temperature-mediated behavior is fully reversible. The structure of pNIPAM microgels was tailored via hard templating and cross-linking of the hydrogel using sacrificial mesoporous cores of vaterite CaCO 3 microcrystals. In addition, the fabrication of hollow thermoresponsive pNIPAM microshells has been demonstrated, utilizing vaterite microcrystals that had narrower pores. The proposed approach for heating-triggered encapsulation and cooling-triggered release into/from pNIPAM microgels may pave the ways for applications of pNIPAM hydrogels for skin and transdermal cooling-responsive drug delivery in the future.

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“…One of the most prevalent being the ability to load bioactive material into the template's intrinsic porous structure. Porous vaterite CaCO 3 has demonstrated enormous loading capacities [11,[119][120][121][122]; lysozyme, for instance, can be loaded up to 500 ± 128 mg/g CaCO 3 within sub-micron crystals [123], and superoxide dismutase can reach up to 240 ± 8 mg/g CaCO 3 in crystals of ~4 µm [124]. Moreover, the loading of such bioactives may be enhanced via the preencapsulation of a polyelectrolyte of affinity to the material of interest.…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

“…The encapsulation of large sensitive macromolecules is possible due to the ability to form and load vaterite at close-to-physiological conditions [124], thereby maintaining the bioactivity of such materials [88]. Vaterite CaCO 3 also proved itself a diverse material as both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO 3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

“…both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

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Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant

Cited by 43 publications

References 50 publications

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO3 Nanoparticles on Different Cell Lines

Cooling-Triggered Release from Mesoporous Poly(N-isopropylacrylamide) Microgels at Physiological Conditions

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

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