2010
DOI: 10.1242/dev.044750
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Abstract: SUMMARYIn vertebrates, canonical Wnt signaling controls posterior neural cell lineage specification. Although Wnt signaling to the neural plate is sufficient for posterior identity, the source and timing of this activity remain uncertain. Furthermore, crucial molecular targets of this activity have not been defined. Here, we identify the endogenous Wnt activity and its role in controlling an essential downstream transcription factor, Meis3. Wnt3a is expressed in a specialized mesodermal domain, the paraxial do… Show more

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Cited by 61 publications
(104 citation statements)
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“…The remaining genes include some known bone morphogenetic protein (BMP)-and fibroblast growth factor (FGF)-inducible genes, reiterating the importance of the cross talk between these pathways, and novel putative Wnt targets (Table 1). Whereas some of these genes may be activated indirectly, Meis3, Gbx2, Cdx4, and Vent1/2 are known to contain functional TCF-binding sites in their promoters that are required for Wnt responsiveness (Haremaki et al 2003;Li et al 2009;Elkouby et al 2010;Hikasa et al 2010). Supporting these findings, a complementary analysis revealed a similar list of genes that are inhibited in ventral mesoderm by Dkk1 (Table 1) (Hufton et al 2006).…”
Section: Putative Transcriptional Targets Of the Wnt Pathway In Axis mentioning
confidence: 93%
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“…The remaining genes include some known bone morphogenetic protein (BMP)-and fibroblast growth factor (FGF)-inducible genes, reiterating the importance of the cross talk between these pathways, and novel putative Wnt targets (Table 1). Whereas some of these genes may be activated indirectly, Meis3, Gbx2, Cdx4, and Vent1/2 are known to contain functional TCF-binding sites in their promoters that are required for Wnt responsiveness (Haremaki et al 2003;Li et al 2009;Elkouby et al 2010;Hikasa et al 2010). Supporting these findings, a complementary analysis revealed a similar list of genes that are inhibited in ventral mesoderm by Dkk1 (Table 1) (Hufton et al 2006).…”
Section: Putative Transcriptional Targets Of the Wnt Pathway In Axis mentioning
confidence: 93%
“…A second class contains many of the previously identified Wnt targets that are expressed ventrally or posteriorly. These genes are Gbx2 (von Bubnoff et al 1996), the Cdx group (Epstein et al 1997;Haremaki et al 2003;Shimizu et al 2005;Keenan et al 2006;Pilon et al 2006), the Vent/Vox/Ved/ Xom group (Gawantka et al 1995;Ladher et al 1996;Onichtchouk et al 1996;Schmidt et al 1996;Imai et al 2001;Ramel and Lekven 2004;Thorpe and Moon 2004), and the Meis group (Meis3) (Choe et al 2009;Elkouby et al 2010). The remaining genes include some known bone morphogenetic protein (BMP)-and fibroblast growth factor (FGF)-inducible genes, reiterating the importance of the cross talk between these pathways, and novel putative Wnt targets (Table 1).…”
Section: Putative Transcriptional Targets Of the Wnt Pathway In Axis mentioning
confidence: 99%
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“…S2A). Treatment with the translational inhibitor cycloheximide (CHX) did not prevent activation of the direct target meis3 (Elkouby et al, 2010) but did block the indirect target hoxb9 (Domingos et al, 2001) (supplementary material Fig. S2B).…”
Section: Screen To Identify Posterior Neural Patterning Genesmentioning
confidence: 99%
“…The homeobox gene gbx2 is a direct target of canonical Wnt signaling and primarily serves to localize the isthmus and induce neural crest (Simeone, 2000;Li et al, 2009). The meis3 gene, which is required for hindbrain and neuronal differentiation, is directly activated by Wnt3a from the dorsal lateral marginal zone (Elkouby et al, 2010(Elkouby et al, , 2012. The caudal homologs Cdx1 and Cdx4 are direct Wnt targets in the mouse (Prinos et al, 2001;Pilon et al, 2006Pilon et al, , 2007 and have overlapping roles in posterior development of the three germ layers (Isaacs et al, 1998;Faas and Isaacs, 2009;van de Ven et al, 2011).…”
Section: Introductionmentioning
confidence: 99%