Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier

Widjaja, Gunawan; Jalil, Abduladheem Turki; Budi, Hendrik Setia; Abdelbasset, Walid Kamal; Efendi, Syahril; Suksatan, Wanich; Rita, Rauza Sukma; Satria, Andri Praja; Aravindhan, Surendar; Saleh, Marwan Mahmood; Shalaby, Mohammed Nader; Yumashev, Alexei Valerievich

doi:10.1016/j.intimp.2022.108537

Cited by 37 publications

(15 citation statements)

References 151 publications

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“…Exosome, a kind of extracellular vesicles secreted by the majority of cell types, contains numerous bioactive components involved in intercellular communication. Accumulating studies have paid attention to the role of exosomal ncRNAs in treatment of IDD ( 98 , 99 ). For instance, Cheng and colleagues ( 100 ) demonstrated that MSC-derived exosomes (MSC-exosomes) could be taken by NP cells and exerted cytoprotective effects against NP cells apoptosis.…”

Section: Therapeutic Strategies For Idd Based On Ncrnasmentioning

confidence: 99%

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

et al. 2022

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Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality of life. The majority of people may suffer from LBP during their life-span, which leading to huge economic burdens to family and society. According to the series of the previous studies, intervertebral disc degeneration (IDD) is considered as the major contributor resulting in LBP. Furthermore, non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), can regulate diverse cellular processes, which have been found to play pivotal roles in the development of IDD. However, the potential mechanisms of action for ncRNAs in the processes of IDD are still completely unrevealed. Therefore, it is challenging to consider ncRNAs to be used as the potential therapeutic targets for IDD. In this paper, we reviewed the current research progress and findings on ncRNAs in IDD: i). ncRNAs mainly participate in the process of IDD through regulating apoptosis of nucleus pulposus (NP) cells, metabolism of extracellular matrix (ECM) and inflammatory response; ii). the roles of miRNAs/lncRNAs/circRNAs are cross-talk in IDD development, which is similar to the network and can modulate each other; iii). ncRNAs have been attempted to combat the degenerative processes and may be promising as an efficient bio-therapeutic strategy in the future. Hence, this review systematically summarizes the principal pathomechanisms of IDD and shed light on the therapeutic potentials of ncRNAs in IDD.

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Section: Therapeutic Strategies For Idd Based On Ncrnasmentioning

confidence: 99%

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

et al. 2022

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“…Similar to TECs or CAFs, these modulators also expand immunosuppressive M2-polarized macrophages and tumor-associated macrophages (TAMs), and also Tregs populations to the induction of immune tolerance [56,57]. In addition, MSCs secreted exosomes contain TGF-β, C1q, and semaphorins, which induce the polarization of M2-macrophages expressing PD-L1 and IL-10, as the contributors to immunotherapy resistance [58][59][60].…”

Section: Mesenchymal Stromal Cellsmentioning

confidence: 99%

Reprogramming the tumor microenvironment to improve the efficacy of cancer immunotherapies

Faraj¹,

Al-Athari²,

Mohie³

et al. 2022

Med Oncol

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The immunotherapeutic approaches based on checkpoint inhibitors, tumor vaccination, immune cell-based therapy, and cytokines were developed to engage the patient's immune system against cancer and better survival of them. While potent, however, preclinical and clinical data have identified that abnormalities in the tumor microenvironment (TME) can affect the efficacy of immunotherapies in some cancers. It is therefore imperative to develop new therapeutic interventions that will enable to overcome tumor-supportive TME and restrain anti-tumor immunity in patients that acquire resistance to current immunotherapies. Therefore, recognition of the essential nature of the tolerogenic TME may lead to a shift from the immunesuppressive TME to an immune-stimulating phenotype. Here, we review the composition of the TME and its effect on tumor immunoediting and then present how targeted monotherapy or combination therapies can be employed for reprogramming educated TME to improve current immunotherapies outcomes or elucidate potential therapeutic targets.

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“…Cuprous oxide NP has many applications in medicine [95][96][97], catalysts, and antimicrobial agent; they can be synthesized with plant extract. Cuprous oxide NP are one of the most important NPs due to the unique properties they possess, such as good conductivity and antibacterial activity [98][99][100]. New progress [101][102][103] in technology/science [104][105][106] has significant impact on health [107][108][109] and life [110][111][112].…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis inorganic cuprous oxide nanoparticles and their antibacterial properties

Binjawhar

Alsharari

Albalawi

et al. 2023

Micro & Nano Letters

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Here, the authors described a sustainable green synthesis approach to synthesize cuprous oxide nanoparticles (NPs) using Olea europaea extract. The resulting synthesized cuprous oxide NPs were characterized by the UV–Visible spectra, scanning electron microscopy (SEM)/energy‐dispersive X‐ray spectroscopy (EDS), transmission electron microscopy (TEM), and X‐ray diffraction (XRD). The average cuprous oxide NPs crystallite size of about 30 nm was calculated using the Scherrer formula. According to TEM, the resulting synthesized cuprous oxide NPs are spherical shaped. The cuprous oxide NP provides good antibacterial activity versus the two strains compared to Olea europaea aqueous extract; cuprous oxide NP has higher MIC against Staphylococcus aureus and Klebsiella pneumoniae.

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Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier

Cited by 37 publications

References 151 publications

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

Reprogramming the tumor microenvironment to improve the efficacy of cancer immunotherapies

Facile green synthesis inorganic cuprous oxide nanoparticles and their antibacterial properties

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