Mesenchymal Stem Cells, Immune Cells and Tumor Cells Crosstalk: A Sinister Triangle in the Tumor Microenvironment

Razmkhah, Mahboobeh; Abtahi, Shabnam; Ghaderi, Abbas

doi:10.2174/1574888x13666180816114809

Cited by 15 publications

(10 citation statements)

References 160 publications

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“…Hcc is a serious threat to human health due to a lack of effective treatments (1,2). inducing apoptosis in tumor cells is currently an important strategy for inhibiting the malignant biological features of cancer (18,19). SMac was discovered by Verhagen and Vaux (20) to localize in mitochondria and regulate cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

et al. 2020

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The present study investigated the effects and molecular mechanism of the second mitochondria-derived activator of caspase (SMac) mimetic birinapant on the proliferation and apoptotic rate of liver cancer cells. Western blotting and reverse transcription-quantitative Pcr were used to detect the protein and mrna expression levels of cellular inhibitor of apoptosis 1 (ciaP1) and tumor necrosis factor receptor-associated factor 3 (TraF3) in the liver cancer cell lines Huh7, H22 and HepG2, and the hepatocyte line aMl12. annexin V-FiTc and Transwell assays were used to assess the effect of birinapant pretreatment on the apoptotic rate and invasive ability of liver cancer cells. lentivirus-mediated silencing of TraF3 was performed in liver cancer cells. Western blotting was used to detect the lentivirus silencing efficiency. A subcutaneous hepatocellular carcinoma model was established in nude mice and 15 days after tumor induction the subcutaneous tumors were measured in each group. immunohistochemistry assays were used to detect the protein expression levels of proliferating cell nuclear antigen and caspase-3. The results suggested that the expression levels of ciaP1 and TraF3 were lower in Huh7, H22 and HepG2 cells compared with aMl12 cells. Pretreatment with birinapant promoted apoptosis and inhibited invasion of liver cancer cells by activating the ciaP1/TraF3 axis. Birinapant also promoted apoptosis and inhibited the growth of subcutaneous hepatocellular carcinoma tumors in nude mice. The present results suggested that the SMac mimetic birinapant may promote apoptosis, and inhibit the proliferation and invasion of liver cancer cells. The molecular mechanism responsible for the effects of birinapant may be related to activation of the ciaP1/TraF3 signaling pathway by birinapant in liver cancer cells.

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Section: Discussionmentioning

confidence: 99%

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

et al. 2020

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“…Targeted cytokine immunotherapy to conquer the heterogeneity of malignant and cancer cell defense is also a hot and difficult topic. MSCs have received great attention in the field of cancer immunotherapy for their excellent targeting and secretory functions, playing an indispensable role in cancer immunomodulatory [111] , [112] . On the one hand, MSCs and secreted exosomes can be used as biological carriers of genetic engineering to achieve the therapeutic effect by loading related immune cytokines.…”

Section: The Prospects Of Mscs In Clinical Applicationsmentioning

confidence: 99%

New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma

Chang

Zhu

et al. 2021

Journal of Bone Oncology

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Highlights The origin of osteosarcoma cells from osteoblasts and mesenchymal stem cells remains controversial. Mesenchymal stem cells regulate the development of osteosarcoma by influencing the tumor microenvironment and mediating cell communication. Mesenchymal stem cells and exosomes secreted by them can be used as good genes and drug carriers for the treatment of osteosarcoma. Mesenchymal stem cells from different tissue sources have different regulatory effects on the development of osteosarcoma.

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“…In short, the bi-interactions between MSCs and tumor cells have been proposed to play a critical role in the growth, survival, metastasis and drug resistance of solid tumors (62,63). But tumor cells alone do not cause the naïve MSCs to acquire all of the features displayed by CA-MSCs (33), indicating the participation of other mediators or factors from the TME in "shaping" the phenotypes and functions of CA-MSCs.…”

Section: Exosomes Mediate the Malignant Transition Of Naïve Mscs By Tumor Cellsmentioning

confidence: 99%

The Origins and Generation of Cancer-Associated Mesenchymal Stromal Cells: An Innovative Therapeutic Target for Solid Tumors

Yang

Zheng

et al. 2021

Front. Oncol.

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Cancer-associated mesenchymal stromal cells (CA-MSCs) have been isolated from various types of tumors and are characterized by their vigorous pro-tumorigenic functions. However, very little is known about the origins and generating process of CA-MSCs, which may facilitate the identification of biomarkers for diagnosis or innovative targets for anti-cancer therapy to restrain the tumor growth, spread and chemotherapy resistance. Current evidences have indicated that both distally recruited and local resident MSCs are the primary origins of CA-MSCs. In a tissue type-dependent mode, tumor cells together with the TME components prompt the malignant transition of tumor “naïve” MSCs into CA-MSCs in a direct cell-to-cell contact, paracrine or exosome-mediated manner. In this review, we discuss the transition of phenotypes and functions of naïve MSCs into CA-MSCs influenced by tumor cells or non-tumor cells in the TME. The key areas remaining poorly understood are also highlighted and concluded herein.

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Mesenchymal Stem Cells, Immune Cells and Tumor Cells Crosstalk: A Sinister Triangle in the Tumor Microenvironment

Cited by 15 publications

References 160 publications

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma

The Origins and Generation of Cancer-Associated Mesenchymal Stromal Cells: An Innovative Therapeutic Target for Solid Tumors

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