Mesenchymal stem cell (MSC) and endothelial progenitor cell (EPC) growth and adhesion in six different bone graft substitutes

Schultheiss, Judith; Seebach, Caroline; Henrich, Dirk; Wilhelm, Kerstin; Barker, John H.; Frank, Johannes

doi:10.1007/s00068-011-0119-0

Cited by 22 publications

(23 citation statements)

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“…In a few in vitro experiments, bone substitutes were combined with BM-MSCs and endothelial progenitor cells (EPCs). It was shown that MSCs can attach to artificial scaffolds that prolong their vitality [20]. Furthermore, a few in vivo studies have indicated that ADSCs secrete large amounts of bone morphogenetic proteins (BMPs), which accelerate osteogenesis [21].…”

Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures (Adv Clin Exp Med 2014, 23, 6, 1011-1017).

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Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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“…Bu konuda yapılan deneysel çalışmalar artık kliniğe uygulanır hale gelmiştir. Mezenkimal kök hücrelerin canlılıklarını sürdürebilmek için bir iskelet formu (scaffold) üzerine yerleştirilerek eklenebildiği ve burada işlevsel olarak çoğalabildiği bilinmektedir (23) . Çocuk cerrahisinde damak plastiği yapılırken alveolar cleft rekonstrüksiyonun da kemik iliği kökenli kök hücrelerin kullanımının deneysel düzeyden çıktığı ve klinik uygulamalara dönüştüğü bildirilmektedir (24) .…”

Section: Rekonstrüktif Cerrahiunclassified

New Horizons in Pediatric Surgery

Şenol¹,

Mir²

2017

tcdd

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“…ACTIFUSE â (APATECH Baxter), a moldable bone graft, is made from silicate substituted calcium phosphate and is 100 percent synthetic. ACTIFUSE â has been shown to be osteostimulative with minimal complications [6,7]. However, it is mainly utilized to repair small defect volumes and is contraindicated for structural and load bearing applications.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, several options exist however each has limitations. Allografts offer organized natural bone material however there is the possibility of infection or rejection of the donor material [6,7]. Ceramic materials have been used alone and after doping with growth factors and are much less of a risk to the patient [7,8].…”

Section: Introductionmentioning

confidence: 99%