Mesenchymal Stem Cell-Derived Small Extracellular Vesicles: A Novel Approach for Kidney Disease Treatment

Lu, Yukang; Wang, Lanfeng; Zhang, Mengting; Chen, Zhiping

doi:10.2147/ijn.s372254

Cited by 20 publications

(16 citation statements)

References 108 publications

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“…Besides soluble cytokines, EVs such as exosomes (30–100 nm in diameter) and microvesicles (100–1,000 nm in diameter) have been described as a different form of cell-to-cell communication through the horizontal transfer of microRNAs (miRNAs), mRNAs, and proteins-to-target cells ( Lu et al, 2022 ). Apart from the stem cells mentioned above, all regions of the nephron can release EVs.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visualization analysis of kidney repair associated with acute kidney injury from 2002 to 2022

Gong

2023

Front. Pharmacol.

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Background: Renal repair is closely related to the prognosis of acute kidney injury (AKI) and has attracted increasing attention in the research field. However, there is a lack of a comprehensive bibliometric analysis in this research area. This study aims at exploring the current status and hotspots of renal repair research in AKI from the perspective of bibliometrics.Methods: Studies published between 2002 and 2022 related to kidney repair after AKI were collected from Web of Science core collection (WoSCC) database. Bibliometric measurement and knowledge graph analysis to predict the latest research trends in the field were performed using bibliometrics software CiteSpace and VOSviewer.Results: The number of documents related to kidney repair after AKI has steadily increased over 20 years. The United States and China contribute more than 60% of documents and are the main drivers of research in this field. Harvard University is the most active academic institution that contributes the most documents. Humphreys BD and Bonventre JV are the most prolific authors and co-cited authors in the field. The American Journal of Physiology-Renal Physiology and Journal of the American Society of Nephrology are the most popular journals in the field with the greatest number of documents. “exosome”, “macrophage polarization”, “fibroblast”, and” aki-ckd transition” are high-frequency keywords in this field in recent years. Extracellular vesicles (including exosomes), macrophage polarization, cell cycle arrest, hippo pathway, and sox9 are current research hotspots and potential targets in this field.Conclusion: This is the first comprehensive bibliometric study on the knowledge structure and development trend of AKI-related renal repair research in recent years. The results of the study comprehensively summarize and identify research frontiers in AKI-related renal repair.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and visualization analysis of kidney repair associated with acute kidney injury from 2002 to 2022

Gong

2023

Front. Pharmacol.

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“…73 Choi et al reported that kidney-derived MSC-EVs led to increased density and perfusion of renal capillaries through the downregulation of hypoxia inducible factor-1α. 74 Conversely, MSC-EVs produced by platelets or lymphocytes can also inhibit angiogenesis, mainly by increasing oxidative stress in target cells. MSC-EVs from lymphocytes can stimulate or inhibit angiogenesis depending on the conditions under which they are generated.…”

Section: Modulating Angiogenesismentioning

confidence: 99%

“…Choi et al. reported that kidney‐derived MSC‐EVs led to increased density and perfusion of renal capillaries through the downregulation of hypoxia inducible factor‐1α 74 …”

Section: Modulating Angiogenesismentioning

confidence: 99%

Mesenchymal stem cell‐derived extracellular vesicles in treatment against renal fibrosis

Wang,

Cui,

et al. 2023

Clinical and Translational Dis

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BackgroundRenal fibrosis (RF) is the main pathological pathway of acute kidney injury and chronic kidney disease. Its main pathological feature is extracellular matrix aggregation in the renal stroma and glomerulus. There is currently no effective treatment to delay or treat RF. Mesenchymal stem cells (MSCs) are multipotent somatic stem cells that can direct differentiation, direct cell‐cell interactions and have secretory activity. The most important secretory activity of MSCs is mediated by extracellular vesicles (EVs). At present, there is increasing evidence that EVs produced by MSCs may be used in regenerative methods of tissue repair.AimThe goal of this review is to present the latest efficacy of MSC‐EVs in the prevention, treatment and improvement of RF caused by acute and chronic kidney injury and reveals the molecular mechanism of MSCs in various models.Results and discussionMSC‐EVs show potential for RF by regulating autophagy, inhibiting apoptosis, countering oxidation, suppressing inflammation, reducing EMT and modulating angiogenesis.ConclusionMSC‐EVs show potential for treating RF. However, more studies establishing their safety, efficiency and specific mechanisms in the context of RF are still needed before further clinical application.

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“…The regenerative potential of mesenchymal stem cells of different origins has been studied and contrasted by numerous research groups (40)(41)(42). The source from which organ-specific mesenchymal stem cells have traditionally been extracted is bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Human Placenta-Derived Mesenchymal Stem Cells Stimulate Neuronal Regeneration By Promoting Axon Growth And Restoring Neuronal Activity

de Laorden,

Simón,

Milla

et al. 2023

Preprint

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Cell therapy is a cutting-edge medical approach that involves the use of cells to treat various diseases and conditions. It harnesses the remarkable regenerative and reparative abilities of cells to restore or replace damaged tissues and promote healing. In the last decades, mesenchymal stem cells have become the cornerstone of cellular therapy due to their unique characteristics. Specifically human placenta-derived mesenchymal stem cells (hPMSCs) are highlighted for their unique features including ease to isolate, non-invasive techniques for large scale cell production, significant immunomodulatory capacity, and high ability to migrate to injuries. Researchers are exploring innovative techniques to overcome the low regenerative capacity of Central Nervous System (CNS) neurons, with one promising avenue being the development of tailored mesenchymal stem cell therapies capable of promoting neural repair and recovery. In this context, we have evaluated hPMSCs as candidate for CNS lesion regeneration using a skillful co-culture model system. Indeed, we have demonstrated the hPMSCs ability to stimulate damaged rat-retina neurons regeneration by promoting axon growth and restoring neuronal activity both under normoxia and hypoxia conditions. With our model we have obtained neuronal regeneration values of 10-12% and axonal length per neuron rates of 19.99, μm/neuron. To assess whether the regenerative capabilities of hPMSCs are contact-dependent effects or it is mediated through paracrine mechanisms, we carried out transwell co-culture and conditioned medium experiments confirming the role of secreted factors in axonal regeneration. It was found that hPMSCs produce brain derived, nervegrowth factors (BDNF, NGF) and Neurotrophin-3, involved in the process of neuronal regeneration and restoration of their physiological activity of neurons. The capability to access axonal physiology is crucial for studying information processing among neurons in healthy and diseased states. We confirm the success of our treatment using the patch clamp technique to study ionic currents in individual isolated living cells, confirming that in our model the regenerated neurons are electrophysiologically active. The outcomes of our neuronal regeneration studies, combined with the axon-regenerating capabilities exhibited by mesenchymal stem cells derived from the placenta, present a hopeful outlook for the potential therapeutic application of hPMSCs in the treatment of neurological disorders.

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Mesenchymal Stem Cell-Derived Small Extracellular Vesicles: A Novel Approach for Kidney Disease Treatment

Cited by 20 publications

References 108 publications

Bibliometric and visualization analysis of kidney repair associated with acute kidney injury from 2002 to 2022

Bibliometric and visualization analysis of kidney repair associated with acute kidney injury from 2002 to 2022

Mesenchymal stem cell‐derived extracellular vesicles in treatment against renal fibrosis

Human Placenta-Derived Mesenchymal Stem Cells Stimulate Neuronal Regeneration By Promoting Axon Growth And Restoring Neuronal Activity

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