Mesenchymal Stem Cell Derived Exosomes Suppress Neuronal Cell Ferroptosis Via lncGm36569/miR-5627-5p/FSP1 Axis in Acute Spinal Cord Injury

Shao, Chenglong; Chen, Yu; Yang, Tengyue; Zhao, Haibiao; Li, Dongzhe

doi:10.1007/s12015-022-10327-x

Cited by 42 publications

(28 citation statements)

References 53 publications

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“…It has been found that in animal models of SCI, the IncGm36569/miRNA-5627-5p/FSP1 axis was inhibited by molecular sponge action and thus targeting of the IncGm36569/miRNA-5627-5p/FSP1 axis to inhibit neuronal Ferroptosis ( Shao et al, 2022 ). In the NADPH-FSP1-CoQ10 pathway, FSP1 has already been reported in basic studies at the molecular level as another target protein for Ferroptosis.…”

Section: The Basic Process Of Ferroptosis and Its Relation To Scimentioning

confidence: 99%

Ferroptosis is a new therapeutic target for spinal cord injury

Bai

Liu²,

Deng³

et al. 2023

Front. Neurosci.

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Spinal cord injury is a serious traumatic disease. As Ferroptosis has been increasingly studied in recent years, it has been found to be closely related to the pathophysiological processes of spinal cord injury. Iron overload, reactive oxygen species accumulation, lipid peroxidation and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, and thus Ferroptosis is thought to be involved in the pathological processes secondary to spinal cord injury. This article highlights the relationship between Ferroptosis and spinal cord injury, lists substances that improve spinal cord injury by inhibiting Ferroptosis, and concludes with a discussion of the problems that may be encountered in the clinical translation of Ferroptosis inhibitors as a means of enabling their faster use in clinical treatment.

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Section: The Basic Process Of Ferroptosis and Its Relation To Scimentioning

confidence: 99%

Ferroptosis is a new therapeutic target for spinal cord injury

Bai

Liu²,

Deng³

et al. 2023

Front. Neurosci.

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“…Plasma-activated medium promotes ferroptosis by decreasing FSP1 expression in human lung cancer cells [40]. Mesenchymal stem cell derived exosomes inhibit neuron ferroptosis by lncGm36569/microRNA (miR)-5627-5p/FSP1 axis in acute spinal cord injury [41], and MiR-672-3p inhibition facilitates neural recovery via the suppression of ferroptosis by FSP1 [42].…”

Section: Ferroptosis Suppressor Protein 1 (Fsp1)mentioning

confidence: 99%

Ferroptosis and Its Role in Chronic Diseases

Liu

Zhu

et al. 2022

Cells

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Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The course of ferroptosis can be accurately regulated by the metabolism of iron, lipids, amino acids, and various signal pathways. In this review, we summarize the basic characteristics of ferroptosis, its regulation, as well as the relationship between ferroptosis and chronic diseases such as cancer, nervous system diseases, metabolic diseases, and inflammatory bowel diseases. Finally, we describe the regulatory effects of food-borne active ingredients on ferroptosis.

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“…The authors also demonstrated that MSC-derived exosomes are involved in the underlying mechanisms of the effect of MSCs on ferroptosis, which could significantly downregulate the expression of prostaglandin-endoperoxide synthase 2 and promote SLC7A11 expression [ 38 ]. Similarly, the suppressive effect of MSCs on ferroptosis was seen in neuronal cells [ 39 ]. In an acute spinal cord injury mouse model, researchers demonstrated that MSCs and their exosomes could ameliorate spinal cord injury through promotion of the expression of ferroptosis inhibitor (FSP1) [ 39 ].…”

Section: Ferroptosis and Bone Homeostasismentioning

confidence: 99%

“…Similarly, the suppressive effect of MSCs on ferroptosis was seen in neuronal cells [ 39 ]. In an acute spinal cord injury mouse model, researchers demonstrated that MSCs and their exosomes could ameliorate spinal cord injury through promotion of the expression of ferroptosis inhibitor (FSP1) [ 39 ]. In addition to the discovery of the antiferroptotic effect of MSCs, the underlying mechanism of ferroptosis in MSCs was also investigated.…”

Section: Ferroptosis and Bone Homeostasismentioning

confidence: 99%

The Regulatory Role of Ferroptosis in Bone Homeostasis

Xiong

Chen

Lin

et al. 2022

Stem Cells International

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Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.

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Mesenchymal Stem Cell Derived Exosomes Suppress Neuronal Cell Ferroptosis Via lncGm36569/miR-5627-5p/FSP1 Axis in Acute Spinal Cord Injury

Cited by 42 publications

References 53 publications

Ferroptosis is a new therapeutic target for spinal cord injury

Ferroptosis is a new therapeutic target for spinal cord injury

Ferroptosis and Its Role in Chronic Diseases

The Regulatory Role of Ferroptosis in Bone Homeostasis

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