Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix

Ohlsson, Lena; Varas, Laura; Kjellman, Christian; Edvardsen, Klaus; Lindvall, Magnus

doi:10.1016/j.yexmp.2003.06.001

Cited by 170 publications

(122 citation statements)

References 15 publications

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“…Therefore the introduction of a transgene into autologous stem cells possesses an attractive cell based delivery strategy [8,29]. On the contrary, other studies observed that MSCs may inhibit tumor growth in animal models [30,31] and posses antitumorigenic effects on a model of Kaposi's sarcoma [32].…”

Section: Discussionmentioning

confidence: 99%

Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation

Altanerová¹,

Horváthová²,

Matúšková³

et al. 2009

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Human adipose tissue-derived mesenchymal (stromal) stem cells (AT-MSCs) and genetically modified to express cytosine deaminase:uracil phosphoribosyltransferase (CDy-AT-MSCs) were treated with hydrogen peroxide in order to induce DNA damage and subsequently evaluate their genetic stability by single cell gel electrophoresis. Both cells types (parental and transgene modified) did not differ in the sensitivity to DNA breaks induction. Potential tumorigenicity of AT-MSCs and CDy-AT-MSCs was tested by subcutaneous inoculation of cell suspension into flank of immunocompromised mice. Dose of 15x10 6 cells was not found to be tumorigenic in given experimental setup. AT-MSCs, CDy-AT-MSCs and MSCs isolated from human lipoma were treated with chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) in attempts to transform them. Surviving cells after genotoxic stress were not transformed but underwent replicative senescence. Irreparable DNA damage caused triggered adipogenic terminal differentiation, rather than apoptosis induction in all kinds of cells tested.

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Section: Discussionmentioning

confidence: 99%

Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation

Altanerová¹,

Horváthová²,

Matúšková³

et al. 2009

neo

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“…However, the overall role of MSC in the tumor microenvironment remains controversial. Although on the one hand, MSC can provide survival, growth and drug resistance signals, 48,54 MSC can also induce cell cycle and growth arrest in epithelial cancer [55][56][57] and leukemia cells. 58 On the basis of these findings, the therapeutic use of MSC to decelerate tumor growth has been proposed.…”

Section: Cxcr4: a Unique Chemokine Receptormentioning

confidence: 99%

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

Burger

Peled²

2008

Leukemia

414

316

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“…Several studies have outlined a direct effect of stromal fibroblasts in cancer initiation and progression, especially in epithelial tumors. 10,11 Although some studies have observed that these cells inhibit tumor growth in murine 12 and rat 13,14 models, others have demonstrated an opposite effect. 15,16 Depending on the system used, MSC have been shown to favor tumor growth either by promoting their invasive abilities via the activation of matrix metalloproteinases 15 and neoangiogenesis 16 or by preventing tumor cells recognition by the immune system.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth

Ramasamy¹,

et al. 2006

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Mesenchymal stem cells (MSC) have received much attention in the field of hematopoietic stem cell transplantation because not only do they support hematopoiesis but also exhibit a profound immunosuppressive activity that can be exploited to prevent undesired alloreactivity. We have previously shown that their immunosuppressive activity is mainly exerted at the level of T-cell proliferation. Here, we show that MSC exhibit a similar antiproliferative activity on tumor cells of hematopoietic and non hematopoietic origin. In vitro, MSC produced the transient arrest of tumor cells in the G 1 phase of cell cycle; this was accompanied by a reduction in the apoptotic rate even when survival factors were limiting. However, when tumor cells were injected into non-obese diabetic-severe combined immunodeficient mice in conjunction with MSC, their growth was much faster as compared to the group receiving only tumor cells. To explain the discrepancy between the in vitro and in vivo behavior, we suggest that MSC have the ability to form a cancer stem cell niche in which tumor cells can preserve the potential to proliferate and sustain the malignant process. We conclude that the clinical use of MSC in conditions in which a malignant disease is involved should be handled with extreme caution.

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Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix

Cited by 170 publications

References 15 publications

Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation

Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth

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