Mescaline and Related Compounds

Patel, Atul

doi:10.1007/978-3-0348-7062-7_1

Cited by 2 publications

(1 citation statement)

References 173 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…bei der Katze keine zuverl/~ssigen Angaben vor, da dieses Alkaloid nur in sehr geringen Mengen in das ZNS eindringt, so dab seine Bestimmung mit Schwierigkeiten verbunden ist und weft die Teehnik der autoradiographischen Dar-stellung wasserlSslicher Substanzen, obgleich sehon yon Ullberg 1954 beschriaben, erst seit wenigen Jahren im allgemeinan zu befriedigenden Resultaten geffihrt hat. Varhaltens~nderungen naeh Mescalingabe sind an M~usen zwar verschiedentliah besahrieben worden (Patel, 1968), in der Regel aber nur Ver~nderungen m den ersten Sttmden naeh Verabreichung der Droge. Block et al (1952) (Fischer u. Wernar, 1968a) ausgewertet.…”

Section: Introductionunclassified

Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen

Korr

Lehr

Seiler

et al. 1969

Psychopharmacologia

View full text Add to dashboard Cite

A utoradiographic Studies on the Distribution o/Mescaline and its Influence on the Central Excitation o/Mice Summary.After the injection of radioactive mescaline into mice the distribution of radioactivity was studied in different organs with biochemical and autoradiographic techniques. The half-life time of mescaline in the brain of mice was found to be about 55 rain. One hour after injection, the highest level of radioactivity was found in the soma rich areas of the cortex and of the brainstem. At this time the choroid plexus contained the highest amount of radioactivity within the brain. Six hours after the mescaline injection the radioactive material was concentrated more in the hippocampus compared with other areas of grey matter, whereas the plexus was nearly free of radioactivity. Motility increased parallel with the enrichment of the radioactivity in the cornu ammonis. Within the retina the layers with myelinated fibers were more radioactive than those containing the perikarya. A marked storage of radioactive material in the perikarya of the spinal ganglia was also observed. In the bone-marrow and in other reticulo-endothelial structures a high concentration of radioactivity was also found. In the liver the radioactivity was accumulated in the bile ducts and around the central veins. These autoradiograms were similar to the pictures which are obtained from Kupffer's cells by injection of Chinese ink. The adrenal medulla and the isles of Langerhans in the pancreas were also marked selectively.

show abstract

Section: Introductionunclassified

Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen

Korr

Lehr

Seiler

et al. 1969

Psychopharmacologia

View full text Add to dashboard Cite

show abstract

Mescaline: Its effects on learning rate and dopamine metabolism in goldfish (Carassius auratus)

et al. 1976

View full text Add to dashboard Cite

The pharmacological action of mescaline on goldfish was studied with the Bitterman-Agranoff shock-avoidance test. In short term experiments with high mescaline doses an increase in learning rates was observed. Similar results were obtained with apomorphine and L-dopa. However, when the fish were exposed to smaller mescaline doses (or to fluphenazine) for 3 days, their ability to avoid electric shock was reduced. Apparently, mescaline induced a release of dopamine which stimulated central dopaminergic systems. Subsequently, MAO destroys the liberated dopamine. Thus, the ensuing dopamine deficit appears to be responsible for the marked changes in behavior in the chronic experiment.

show abstract

Mescaline and Related Compounds

Cited by 2 publications

References 173 publications

Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen

Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen

Mescaline: Its effects on learning rate and dopamine metabolism in goldfish (Carassius auratus)

Contact Info

Product

Resources

About