Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection

Kute, Vivek B.; Vanikar, Aruna V; Shah, PR; Gumber, Manoj R.; Patel, Himanshu V.; Trivedi, Hargovind L

doi:10.4103/0971-4065.127902

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Mesangial proliferative glomerulonephritis (MsPGN) is characterized by MC proliferation and various degrees of extracellular matrix (ECM) thickening [ 4 , 5 ]. Immunologically, MsPGN can be an IgA- or non-IgA nephropathy.…”

Section: Introductionmentioning

confidence: 99%

Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms

et al. 2017

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BackgroundIt has been reported that trifluoperazine (TFP) inhibits proliferation of cancer cells, however, the effects of TFP in renal proliferation diseases are still unclear. This study examined the effects of TFP on proliferation of human renal mesangial cells and analyzed the underlying mechanisms.Material/MethodsCell proliferation in vivo was determined by HE staining, immunohistochemistry of proliferating cell nuclear antigen (PCNA), and Western blot analysis (Ki-67 and PCNA). Effects of different TFP concentrations and treatment duration on cell proliferation and cell cycle were analyzed using the MTT assay and flow cytometry. Expression of G0/G1 phase cell cycle-related proteins and TFP-induced MAPK and PI3K/AKT signaling pathways was estimated with Western blot analysis.ResultsOur findings suggest that TFP inhibits cell proliferation in a dose- and time-dependent manner and decreased PCNA and Ki-67 levels in lupus MRL/lpr mice. TFP arrested the cell cycle in the G0/G1 phase, down-regulating cyclin D1, CDK2, and CDK4, and up-regulating p21 expression in a dose-dependent manner. In addition, TFP inhibited p-AKT and p-JNK, possibly by suppressing the activation of PI3K/AKT and JNK/MAPK signaling pathways. TFP treatment remarkably reduced the levels of serum creatinine (Cr) in lupus mice.ConclusionsTFP exhibits inhibitory activity against mesangial cells in vivo and in vitro, which is associated with G1 cell cycle arrest by inactivation of PI3K/AKT and JNK/MAPK signaling pathways. These results suggest the potential of TFP in treatment of mesangial proliferative diseases.

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Section: Introductionmentioning

confidence: 99%

Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms

et al. 2017

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“…Observamos que hubo una evolución positiva de la IRA en ambos casos en concomitancia con el uso de corticoesteroides, los que en el primer caso estuvo motivado por la sospecha de una patología autoinmune pulmonar que posteriormente se descartó y en el segundo caso por el compromiso respiratorio. Es posible que el compromiso glomerulonefrítico con los mecanismos patogénicos ya comentados, haya disminuido con los corticoesteroides administrados 9,10 . Sin embargo, no contamos con un estudio histopatológico renal que hubiese demostrado una condición proclive a mejorar con corticoesteroides, por lo que solo podemos plantear un posible rol beneficioso.…”

Section: Discussionunclassified

Glomerulonefritis aguda con requerimiento de diálisis asociada a influenza A H1N1pdm09: Comunicación de dos casos

Aceituno

Fíca

Fasce

et al. 2017

Rev. chil. infectol.

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Acute glomerulonephritis with hemodialysis requirement secondary to influenza A H1N1pdm09 infection. Report of two cases Acute renal failure (ARF) requiring hemodialysis is not common among patients affected by influenza. We report two unvaccinated adult patients with smoking habit, which were admitted with severe influenza A H1N1pdm09 that evolved with shock and required mechanical ventilation. Both patients developed progressive renal failure with oliguria/anuria, associated with urinary of inflammatory sediment with proteinuria, microhematuria and in one case also with hypocomplementemia, suggesting acute glomerulonephritis. Renal replacement therapy (RRT) was required in both cases. In one patient, who died of late complications, sequencing of the HA1 segment revealed the previously described D222N mutation associated to severe cases. ARF with RRT appears to be an uncommon complication of patients hospitalized for influenza A H1N1pdm09 and may be secondary to acute glomerulonephritis.

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“…In most cases, the development of rhabdomyolysis has been reported as an additional risk factor for AKI in these patients [ 135 , 136 ]. In addition, a few cases of glomerulonephritis [ 137 , 138 , 139 ] or thrombotic microangiopathy [ 140 ] have been described. However, none of these have evidenced influenza’s presence in kidney epithelial and/or glomerular cells.…”

Section: Respiratory Virusesmentioning

confidence: 99%

Virus-Associated Nephropathies: A Narrative Review

Masset

Turnier

Bressollette-Bodin

et al. 2022

IJMS

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While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity or direct or indirect viral-associated nephropathy. We review here the described virus-associated nephropathies in order to guide diagnosis strategies and treatments in cases of acute kidney injury (AKI) occurring concomitantly with a viral infection. The occurrence of virus-associated nephropathy depends on multiple factors: the local epidemiology of the virus, its ability to infect renal cells and the patient’s underlying immune response, which varies with the state of immunosuppression. Clear comprehension of pathophysiological mechanisms associated with a summary of described direct and indirect injuries should help physicians to diagnose and treat viral associated nephropathies.

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Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection

Cited by 4 publications

References 17 publications

Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms

Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms

Glomerulonefritis aguda con requerimiento de diálisis asociada a influenza A H1N1pdm09: Comunicación de dos casos

Virus-Associated Nephropathies: A Narrative Review

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