Merkel cell carcinoma of the upper extremity: Case report and an update

Papamichail, Michail; Nikolaidis, Ioannis; Nikolaidis, Nicolas; Glava, Chryssoula; Lentzas, I.; Marmagkiolis, Konstantinos; Karassavsa, Kriton; Digalakis, M.

doi:10.1186/1477-7819-6-32

Cited by 18 publications

(31 citation statements)

References 39 publications

(59 reference statements)

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“…[4] MCC most commonly occurs in the head and neck (50%), upper and lower limbs (35-40%), and less than 10% in the trunk. [5] Similarly, our patient also had MCC in the head and neck region. The epidemiological studies have revealed that large tumor size, male sex, truncal site, nodal/distant disease at presentation, and duration of disease before presentation are poor prognostic factors.…”

Section: Discussionmentioning

confidence: 85%

Merkel cell carcinoma-A rare primary neuroendocrine skin tumor: Case report and discussion

Gupta¹,

Samra²,

Nimbran³

et al. 2014

J Can Res Ther

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Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous primary small cell carcinoma with an unfavorable prognosis. It is a disease of the sun exposed skin of the elderly commonly involving the head, neck, and extremities. Though most cases present as localized disease, treatment should be definitive with wide excision of the primary lesion (2-3 cm margin) and prophylactic lymphadenectomy followed by irradiation to the primary site. Even when locoregional control is achieved, close surveillance is required due to high rates of local and systemic relapses. Chemotherapy is preserved for systemic disease, though the success of this treatment is limited and no chemotherapy protocol has been shown to improve survival.

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Section: Discussionmentioning

confidence: 85%

Merkel cell carcinoma-A rare primary neuroendocrine skin tumor: Case report and discussion

Gupta¹,

Samra²,

Nimbran³

et al. 2014

J Can Res Ther

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“…It has very rarely been described on the fingers or the hand, with only few case reports that we are aware of [3][4][5][6][7][8][9][10][11][12][13][14][15]16]. Because of its rarity and the small numbers of patients in clinical reports, management is not standardized.…”

Section: Discussionmentioning

confidence: 97%

“…Adjuvant radiation therapy has been clearly proven to provide benefit in local regional recurrence rate [3,5]. However, distant metastases and overall survival seem to be similar compared to those who did not receive radiation therapy [14]. Chemotherapy is recommended in case of distant metastases.…”

Section: Discussionmentioning

confidence: 99%

Merkel cell carcinoma of the hand: Case report and literature review

Daghistani

Younan

Brutus

2010

Chirurgie de la Main

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“…For an MCC metastatic disease (Stage III), radio- and chemotherapy are employed with a palliative intent [23]. MCC is predominantly a radio-sensitive malignancy, and utilization of radiation therapy is highly advised [24].…”

Section: Discussionmentioning

confidence: 99%

Merkel Cell Carcinoma of Left Groin: A Case Report and Literature Review

Abu‐Zaid

Azzam

Al-Wusaibie

et al. 2013

Case Reports in Oncological Medicine

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Merkel cell carcinoma (MCC) is an uncommon highly aggressive skin malignancy with an increased tendency to recur locally, invade regional lymph nodes, and metastasize distally to lung, liver, brain, bone, and skin. The sun-exposed skin of head and neck is the most frequent site of involvement (55%). We report the case of a 63-year-old Caucasian male patient who presented with a recurrent left inguinal mass for the third time after surgical resection with safe margins and no postoperative radio- or chemotherapy. The presented mass was excised, and pathological diagnosis revealed recurrent MCC. The patient underwent postoperative radiation therapy, and 6 months later, he developed a right groin mass which was resected and pathological diagnosis confirmed metastatic MCC. Six months later, patient developed an oropharyngeal mass which was unresectable, and pathological biopsy confirmed metastatic MCC. Patient was offered palliative radio- and chemotherapy. In this paper, we also present a brief literature review on MCC.

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Merkel cell carcinoma of the upper extremity: Case report and an update

Cited by 18 publications

References 39 publications

Merkel cell carcinoma-A rare primary neuroendocrine skin tumor: Case report and discussion

Merkel cell carcinoma-A rare primary neuroendocrine skin tumor: Case report and discussion

Merkel cell carcinoma of the hand: Case report and literature review

Merkel Cell Carcinoma of Left Groin: A Case Report and Literature Review

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