Mephenesin contact dermatitis with erythema multiforme features

Degreef, Hugo; Bonamie, A.; Derheyden, D. van; Dooms‐Goossens, A.

doi:10.1111/j.1600-0536.1984.tb00103.x

Cited by 24 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patch testing in patients who have had EM may reveal more than 1 strong positive reaction (5,6,22,24,27,28,30,38,39), as in our patient, a strong reaction to a single agent (10,11,13,22,(31)(32)(33)37) or negative results (29,34). The offending agents may be powerful sensitizers or sensitizers corning into contact with the skin in high concentration or frequently (22).…”

Section: Discussionmentioning

confidence: 46%

Erythema multiforme reaction to patch testing

O'Donnell

Tan

1992

Contact Dermatitis

View full text Add to dashboard Cite

A young woman developed erythema multiforme in association with multiple patch test reactions. Sequential patch testing revealed 2 true positive reactions (colophony and fragrance mix), and was not associated with flare of erythema-multiforme-type lesions. The development of erythema multiforme should be included in the list of possible adverse reactions to patch testing, albeit a rare occurrence.

show abstract

Section: Discussionmentioning

confidence: 46%

Erythema multiforme reaction to patch testing

O'Donnell

Tan

1992

Contact Dermatitis

View full text Add to dashboard Cite

show abstract

“…An EM-like picture as an expression of contact allergy has previously been described for many topical medications: bufexamac (19,20), chloramphenicol (21), dinitrochlorobenzene (22), diphenylcyclopropenone (23), econazole (24), ethylenediamine and clioquinol (25), idoxirudine (26), ketoprofen (27), lincomycin (28), mafenide acetate (29), mephenesin (30,31), neomycin (25), povidone iodine (32), proflavine (33,34), promethazine (25), pyrrolnitrin (25,26,35), scopolamine (36), sulfonamide (25,37,38), and vitamin E (39). Phenylbutazone can now be added to this list.…”

Section: Discussionmentioning

confidence: 86%

“…Phenylbutazone can now be added to this list. Generally, EM-like lesions are considered to be an id-like reaction occurring with strong sensitization or with penetrationenhancing substances, such as methyl nicotinate (30,31) as was present in the revulsive cream.…”

Section: Discussionmentioning

confidence: 99%

Erythema‐multiforme‐like contact dermatitis due to phenylbutazone

1995

Self Cite

View full text Add to dashboard Cite

A 65-year-old woman presented with a severely itchy prethoracal eruption of erythematous, edematous papules and papulovesicles. These were much more pronounced on the right side, with some presternal confluence, and had already been spreading for 3 days. She also had erythematous papules on both inner thighs. A week before the onset, she had applied the revulsive (counterirritant) cream NF V for 4 days to the right side of the thorax for muscle pain, which she stopped when the eruption started. Revulsive cream contains phenylbutazone as active ingredient and also menthol, cetyl alcohol, propylene glycol, lavender oil, and methyl nicotinate. In spite of a corticosteroid cream and an oral antihistamine, the dermatitis spread. She had also been taking diphenylhydantoin and levodopa for many years and piroxicam for I week.As she recalled a reaction I 0 years previously after using a phenylbutazone-containing ointment (Butazolid-ine®), and because of suspicion of allergy to the revulsive cream and its failure to respond to topical corticosteroids, oral methylprednisolone was given. 2 days later, the eruption had spread and become more painful. The right side of the thorax (the left being less affected) showed a monomorphic eruption of papulopustules, with confluence presternally and in the right axilla. There was a sharp delineation towards the back. A toxicoderma or viral rash was considered as the diagnosis. Systemic corticosteroid was stopped and a menthol lotion prescribed. By 5 days after the 2nd visit, however, large plaques had appeared in the precordal region, right submammary fold and under the right axilla, by confluence of erythematous macules and papules. On the right breast, cocardiform lesions were present. A potent corticosteroid ointment was prescribed, which the patient applied just once. All the lesions regressed in a week.Patch tests with the standard series and with the patient's own medications yielded the following results: D2 D3 Standard series balsam of Peru + fragrance mix ?+ ++ Own medications revulsive cream NF V ++ +++ Butazolidine® ointment ++ +++ phenylbutazone (2% pet.) ++ ++ oxyphenbutazone (5% pet.)This patient had thus developed allergic contact dermatitis from the revulsive cream, having previously been sensitized by Butazolidine® ointment. Discussion

show abstract

“…According to our observation, pyrrolnitrin can trigger this kind of eruption [25, 26]. Other causative drugs include sulfonamide [27, 28], promethazine [25], neomycin [25], mafenide acetate [29], ethylenediamine [25, 30], and mephenesin [31, 32]. Among nonsteroid anti-inflammatory drugs, phenylbutazone [33], bufexamac [34], and mofebutazone [35] have been reported.…”

Section: Erythema Multiforme-like Contact Dermatitismentioning

confidence: 99%

Noneczematous Contact Dermatitis

et al. 2013

View full text Add to dashboard Cite

Irritant or allergic contact dermatitis usually presents as an eczematous process, clinically characterized by erythematoedematovesicous lesions with intense itching in the acute phase. Such manifestations become erythematous-scaly as the condition progresses to the subacute phase and papular-hyperkeratotic in the chronic phase. Not infrequently, however, contact dermatitis presents with noneczematous features. The reasons underlying this clinical polymorphism lie in the different noxae and contact modalities, as well as in the individual susceptibility and the various targeted cutaneous structures. The most represented forms of non-eczematous contact dermatitis include the erythema multiforme-like, the purpuric, the lichenoid, and the pigmented kinds. These clinical entities must obviously be discerned from the corresponding “pure” dermatitis, which are not associated with contact with exogenous agents.

show abstract

Mephenesin contact dermatitis with erythema multiforme features

Cited by 24 publications

References 22 publications

Erythema multiforme reaction to patch testing

Erythema multiforme reaction to patch testing

Erythema‐multiforme‐like contact dermatitis due to phenylbutazone

Noneczematous Contact Dermatitis

Contact Info

Product

Resources

About