Menopause—Biology, consequences, supportive care, and therapeutic options

Davis, Susan R.; Pinkerton, JoAnn; Santoro, Nanette; Simoncini, Tommaso

doi:10.1016/j.cell.2023.08.016

Cited by 18 publications

(3 citation statements)

References 207 publications

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“…Additionally, age categories were defined based on the main causes of anemia that vary depending on sex and age 26 , 27 : 20–45 years, 46–64 years and ≥ 65 years 28 , 29 . Gynecological disorders and maternal hemorrhage are important contributors to the anemia burden, especially in women of reproductive age, so we divided the participants into three groups: the premenopausal, perimenopausal, and postmenopausal groups 30 , 31 . The equivalent age categories were used when analyzing male participants.…”

Section: Methodsmentioning

confidence: 99%

The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study

Kim,

Lee,

Kim

et al. 2024

Sci Rep

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Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects of anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], and mean corpuscular hemoglobin concentration [MCHC]) on CKD-related outcomes by using hazard ratios from a biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox proportional hazard models revealed a higher all-cause mortality risk in the > 45 years and CKD groups than in the early CKD group. Hemoglobin, hematocrit and MCHC were inversely related to all-cause mortality; RDW was related to mortality. Single mediation analysis showed greater mediating effects of anemia indicators on CKD and mortality in the elderly (> 65 years) population than those in the general population. In the multimediation analysis, the combined mediating effect of anemia was higher in the CKD population than in the general population. This study showed a proportional increase in the mediating effect of anemia with CKD stage, suggesting potential therapeutic avenues. However, further exploration of other mediating factors on kidney outcomes is necessary.

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Section: Methodsmentioning

confidence: 99%

The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study

Kim,

Lee,

Kim

et al. 2024

Sci Rep

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“…Si bien el diagnóstico de la menopausia es clínico, rara vez es necesario medir las gonadotropinas (hormona foliculoestimulante -FSH-y hormona luteinizante -LH-); examen que resulta útil para diferenciar entre amenorrea debida a la menopausia y amenorrea por afecciones como el síndrome de ovario poliquístico o causas hipotalámicas (4). Una FSH elevada con estradiol bajo apoya el diagnóstico de menopausia, ante la duda se puede confirmar en dos ocasiones, con cuatro semanas de diferencia (de manera óptima, al menos cuatro semanas después de suspender cualquier hormona anticonceptiva) (5,6).…”

Section: Introductionunclassified

Prevalencia y severidad de los síntomas de la menopausia en mujeres mayores de 60 años

Espitia de la Hoz

2024

Rev.ACE

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Contexto: los síntomas de la menopausia pueden ser tan severos o prolongados en el tiempo, con la posibilidad de afectar la calidad de vida de las mujeres que los padecen. Objetivo: determinar la prevalencia y la severidad de los síntomas de la menopausia en mujeres de 60 años o más, y conocer los factores de riesgo asociados. Metodología: estudio de corte transversal con una muestra de 117 mujeres de 60 años o más con útero intacto y sintomatología menopaúsica, residentes en Quindío, Colombia, entre 2017 y 2023. Se evaluó la calidad de vida con el instrumento Menopause Rating Scale (MRS) y se hizo un análisis descriptivo. Resultados: la edad promedio de las mujeres fue de 67,53 ± 8,24 años; en el total de las participantes, la prevalencia de sintomatología de la menopausia fue del 9,87?%, predominado los sofocos/bochornos (80,34?%). En la escala MRS, el dominio urogenital reportó el mayor impacto en la severidad de la sintomatología (promedio: 8,94 ± 2,07 puntos) y la sequedad vaginal fue la queja más frecuente (58,97?%). Entre los factores asociados destacan la menopausia precoz (OR: 3,87; IC 95?%: 1,81-8,33) y el tabaquismo (OR: 2,97; IC 95?%: 1,44-6,31). La mayor escolaridad (OR: 0,34; IC 95?%: 0,16-0,91) mostró ser un factor protector. El 27,35?% del total de las participantes arrojó una puntuación ? 16 (severa) en la intensidad de la sintomatología según la escala MRS, lo que es compatible con la necesidad de tratamiento. La eficiencia laboral se afectó de forma severa en el 20,51?% de las mujeres, seguida de las responsabilidades del hogar con el 15,38?%. Conclusiones: los síntomas de la menopausia pueden hacerse presentes en mujeres de 60 años o más, siendo descritos por la décima parte de las residentes del departamento del Quindío.

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“…However, regardless of their cultural background and medical histories, nearly all women start to have physical, psychological and emotional disturbances after mid-forties [ 3 ]. Those turmoil coincide with the loss of ovarian reproductive function, is an inevitable component of ageing and happens at a time in a woman’s life when she is frequently actively involved in raising her family or handling a full-time job, during which time she might also have the responsibility of caring for ageing parents [ 4 ]. The majority of women affected by marked fluctuations in levels of sex hormones are often puzzled by the remarkable changes in mood, sleep patterns, and memory, as well as the onset of vasomotor and urogenital symptoms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis

Fang,

Liu,

Zhang

et al. 2024

BMC Public Health

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Background Women at middle age are puzzled by a series of menopausal disturbances, can be distressing and considerably affect the personal, social and work lives. We aim to estimate the global prevalence of nineteen menopausal symptoms among middle-aged women by performing a systematic review and meta-analysis. Methods Comprehensive search was performed in multiple databases from January, 2000 to March, 2023 for relevant studies. Random-effect model with double-arcsine transformation was used for data analysis. Results A total of 321 studies comprised of 482,067 middle-aged women were included for further analysis. We found varied prevalence of menopausal symptoms, with the highest prevalence of joint and muscular discomfort (65.43%, 95% CI 62.51–68.29) and lowest of formication (20.5%, 95% CI 13.44–28.60). Notably, South America shared dramatically high prevalence in a sort of menopausal symptoms including depression and urogenital symptoms. Besides, countries with high incomes (49.72%) had a significantly lower prevalence of hot flashes than those with low (65.93%), lower-middle (54.17%), and upper-middle (54.72%, p < 0.01), while personal factors, such as menopausal stage, had an influence on most menopausal symptoms, particularly in vaginal dryness. Prevalence of vagina dryness in postmenopausal women (44.81%) was 2-fold higher than in premenopausal women (21.16%, p < 0.01). Furthermore, a remarkable distinction was observed between body mass index (BMI) and prevalence of sleep problems, depression, anxiety and urinary problems. Conclusion The prevalence of menopausal symptoms affected by both social and personal factors which calls for attention from general public.

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Menopause—Biology, consequences, supportive care, and therapeutic options

Cited by 18 publications

References 207 publications

The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study

The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study

Prevalencia y severidad de los síntomas de la menopausia en mujeres mayores de 60 años

Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis

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