Menopause and illness course in bipolar disorder: A systematic review

Perich, Tania; Ussher, Jane M.; Meade, Tanya

doi:10.1111/bdi.12530

Cited by 22 publications

(14 citation statements)

References 38 publications

(104 reference statements)

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“…Menopause, a natural physiological process for women, refers to a series of dysfunctions in the autonomic nervous system due to hormone fluctuation induced by ovarian failure, accompanied with neuropsychological symptoms, such as anxiety, depression, and cognitive deterioration [1, 2]. These psychological disorders have a negative impact on the quality of life of menopausal women in varying degrees especially taking the increased life expectancy into consideration [3].…”

Section: Introductionmentioning

confidence: 99%

Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy

Zhou

Zheng

Sharma

et al. 2019

Oxidative Medicine and Cellular Longevity

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Our previous study has demonstrated the effects of aqueous extract of lily bulb in alleviating menopause-related psychiatric symptoms in ovariectomized (OVX) mice. This study sought to further investigate the psychotropic effects of total polysaccharides of lily bulb (TPLB) against anxiety, depression, and cognitive deterioration and the underlying mechanisms in OVX mice using behavioral, neurochemical, molecular, and proteomic approaches in comparison with estrogen therapy. While TPLB and estradiol showed similar effects in reducing OVX-induced anxiety, depression, and cognitive impairment, the psychotropic effects of TPLB were more closely associated with the predominant activation of estrogen receptors (ERs) and regulation of brain regional neurotransmitters and neurotrophins with minor effects on the uterus. Estradiol had similar potencies in binding affinity at ERα and ERβ, which caused widespread genetic and epigenetic effects. In contrast, TPLB displayed a higher affinity at ERβ than ERα, triggering the specific Ras/Akt/ERK/CREB signaling pathway without affecting any epigenetic activity. TPLB additionally modulated multiple proteins associated with mitochondrial oxidative stress, but estradiol did not. These results indicate that TPLB has comparable efficacy in reducing menopause-associated neuropsychological symptoms with a better safety profile compared to estrogen therapy. We suggest that TPLB could serve as a novel agent for menopause syndrome.

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“…Depression occurrence in female patients are twice as many as male patients ( 12 ), which suggested that depression is related to sex hormone ( 13 , 14 ). In addition, menopause depression is a well-known symptom for menopausal period ( 15 , 16 ), which is due to the ovarian dysfunction 1 year after menopause ( 17 ). The major symptom of menopause depression is similar to that of major depression ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Jing

Yang

et al. 2018

Front. Psychiatry

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Objective: Previously, we showed that neuromodulators are important factors involved in depression, here we aim to further investigate the interactions between neuromodulators and sex hormone involved in menopause related depression in rats.Methods: Menopausal depression was made with bilateral ovariectomies in female SD rats followed by chronic mild unpredictable stress treatment for 21 days. Thirty six rats were randomly divided into four groups: sham surgery group, sham/stress group, surgery group, surgery/stress group. Then open-field locomotor scores and sucrose intake were employed to observe behavior changes. The levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) in the cerebral spinal fluid and serum adrenocorticotropic hormone (ACTH), cortisone were determined with High-performance liquid chromatography (HPLC). Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured with radioimmunoassay.Results: The open-field locomotor scores and sucrose intake were significantly decreased after the surgery and stress treatment (p < 0.01). The Serum E2 level decreased significantly after the surgery (p < 0.01), but serum LH, FSH levels increased significantly in the surgery group than the sham surgery group (p < 0.01). The cortisone levels increased significantly in sham/stress group than that in the sham surgery group during the first 2 weeks at stressful treatment, but decrease afterwards. The monoamine levels in the surgery/stress group were much lower than those in the sham surgery group (p < 0.01). The correlation analysis found that LH and FSH are related more to the neurotransmitter release than E2.Conclusion: Ovary removal rats showed depression-like behaviors, with LH and FSH increase and monoamine decrease, and the levels of these monoamines in the stress treated groups changed only after the stressful treatment. The LH, FSH hormone increasing might be the reason for the lower monoamine release, which in turn might be the reason for depressed syndromes in the menopause. The cortisone and ACTH in the serum in the surgery/stress group were much higher than that in the sham surgery group.

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“…Many parts of the brain that are related to aging may also be sensitive to shifts in hormone levels: for example, gonadal changes, which usually occur around mid-life, are thought to be associated with changes in cognitive function [ 8 ], and mood symptoms are well known to be habitual during the menopause transition period [ 9 , 10 ]. Mood symptoms such as depression and anxiety, along with hot flushes and night sweats, may be affiliated with a negative experience of menopause [ 8 ]. The experience of menopause is influenced by the cultural and social context.…”

Section: Introductionmentioning

confidence: 99%

Benefits of Adding an Aquatic Resistance Interval Training to a Nutritional Education on Body Composition, Body Image Perception and Adherence to the Mediterranean Diet in Older Women

et al. 2021

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The human population is increasing due to lengthening life expectancy, but the quality of life and health of people is moving in the opposite direction. The purpose of this study is to evaluate how aquatic resistance interval training can influence body composition, body image perception and adherence to the Mediterranean diet (MD) in older women participants in a nutrition education program and to study the relation between these variables. Thirty-four participants aged 69 ± 4 years were randomly assigned into two groups: experimental (aquatic resistance interval training plus nutritional intervention) and control (nutritional intervention). The intervention consisted of resistance training in an aquatic environment carried out for 14 weeks (three sessions per week; 60 min each). Body composition, body image perception and adherence to MD diet were evaluated at baseline and 14 weeks. No significant differences were found between groups regarding body image perception and adherence to the MD. There was a significant increase in muscle mass (kg) (p < 0.001) and a significant decrease in fat mass (kg) (p < 0.001) in the intervention group when compared to the control group. The addition of aquatic resistance interval training to a nutritional intervention was not sufficient to change body image perception and adherence to MD but produced improvement in body composition (through an increase in muscle mass and decrease on fat mass) in older women.

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“…Comorbid premenstrual dysphoric disorder and bipolar disorder may increase disease severity and the illness burden (Slyepchenko et al, 2017). Menopause (mostly at age 50 years) may increase overall bipolar disorder symptoms, especially depression (46-91%; Perich, Ussher, & Meade, 2017). Menopause (mostly at age 50 years) may increase overall bipolar disorder symptoms, especially depression (46-91%; Perich, Ussher, & Meade, 2017).…”

mentioning

confidence: 99%

“…Older-age bipolar disorder (>60 years) represents 25% of the patients with bipolar disorder and exhibits different pathogenesis; it requires different clinical care (Sajatovic et al, 2015). Menopause (mostly at age 50 years) may increase overall bipolar disorder symptoms, especially depression (46-91%; Perich, Ussher, & Meade, 2017). However, the role of hormones in bipolar disorder is unclear.…”

mentioning

confidence: 99%

Association of hysterectomy with bipolar disorder risk: A population‐based cohort study

et al. 2019

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Background: Hormonal fluctuations may trigger the onset of bipolar disorder. We designed a longitudinal follow-up study to evaluate the association between hysterectomies and bipolar disorder risk. Methods: We conducted a large retrospective cohort study using Taiwan's National Health Insurance Research Database. A total of 4,337 women aged 30 to 50 years who underwent the hysterectomy during 2000-2013 were selected and 17,348 patients without hysterectomy were selected for comparison (1:4 match). Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI). Results: During the follow-up of 7.93 years, 20 participants with hysterectomy and 28 without hysterectomy developed bipolar disorder. Receiving hysterectomy was associated with the risk of developing bipolar disorder (adjusted IRR = 2.80; 95% CI = 2.54-3.09). Women with hysterectomy had a higher risk of bipolar disorder in follow-up durations of <1 year (adjusted IRR = 2.18 with 95% CI = 1.94-1.45) and ≥1 year (adjusted IRR = 2.85 with 95% CI = 2.58-3.15). Endometriosis and Premarin use increased bipolar disorder incidence in the hysterectomy group (adjusted IRR = 3.17 [95% CI = 2.83-3.56] and 4.22 [95% CI = 3.71-4.80], respectively). Conclusion: This study concluded that women with hysterectomy have an increased risk of bipolar disorder. Endometriosis and hormone therapy may add to the risk of bipolar disorder after hysterectomy. Knowledge about how surgical or natural hormonal withdrawal influences mood is fundamental and emphasizes the importance of coordinated psychiatric and gynecological care. K E Y W O R D S bipolar disorder, cohort study, epidemiology, hysterectomy, women

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Menopause and illness course in bipolar disorder: A systematic review

Cited by 22 publications

References 38 publications

Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy

Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Benefits of Adding an Aquatic Resistance Interval Training to a Nutritional Education on Body Composition, Body Image Perception and Adherence to the Mediterranean Diet in Older Women

Association of hysterectomy with bipolar disorder risk: A population‐based cohort study

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