Meniscal tissue regeneration using a collagenous biomaterial derived from porcine small intestine submucosa

Gastel, Jonathan A.; Muirhead, William; Lifrak, Joseph T.; Fadale, Paul D.; Hulstyn, Michael J.; Labrador, Daniel

doi:10.1053/jars.2001.20959

Cited by 76 publications

(43 citation statements)

References 23 publications

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“…The first studies that used collagen matrix scaffolds date from the late 80s and early 90s [20][21][22]. Although these studies were preliminary and mostly experimental, they helped define the parameters of the scaffolds used more recently.…”

Section: Collagen Matrix Scaffoldsmentioning

confidence: 99%

“…Although these studies were preliminary and mostly experimental, they helped define the parameters of the scaffolds used more recently. At that time, studies both in dogs [20] and rabbits [21] revealed significant histologic findings in the cartilage of the femoral condyles of the animals that were treated with unseeded small intestinal submucosa (SIS) during a period of 6-12 months following a partial medial meniscectomy compared with the animals that underwent a simple meniscectomy. However, a more recent study has contradicted these results [23].…”

Section: Collagen Matrix Scaffoldsmentioning

confidence: 99%

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Updates in biological therapies for knee injuries: menisci

Kaleka

Debieux

Astur

et al. 2014

Curr Rev Musculoskelet Med

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The preservation of meniscal tissue is paramount for long-term joint function, especially in younger patients who are athletically active. Many studies have reported encouraging results following the repair of meniscus tears, including both simple longitudinal tears located in the periphery and complex multiplanar tears that extend into the central third avascular region. However, most types of meniscal lesions are managed with a partial meniscectomy. Options to restore the meniscus range from an allograft transplantation to the use of synthetic and biological technologies. Recent studies have demonstrated good long-term outcomes with meniscal allograft transplantation, although the indications and techniques continue to evolve, and the long-term chondroprotective potential of this approach has yet to be determined. Several synthetic implants, most of which are approved in the European market, have shown some promise for replacing part of or the entire meniscus, including collagen meniscal implants, hydrogels, and polymer scaffolds. Currently, there is no ideal implant generated by means of tissue engineering. However, meniscus tissue engineering is a fast developing field that promises to develop an implant that mimics the histologic and biomechanical properties of a native meniscus.

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Section: Collagen Matrix Scaffoldsmentioning

confidence: 99%

Section: Collagen Matrix Scaffoldsmentioning

confidence: 99%

Updates in biological therapies for knee injuries: menisci

Kaleka

Debieux

Astur

et al. 2014

Curr Rev Musculoskelet Med

View full text Add to dashboard Cite

show abstract

“…Badylak et al (1989) first made a vascular graft in dogs using SIS successfully. SIS has been also used in different organ systems (Gastel et al, 2001) and it has given good results on host tissue regeneration (Ashley et al, 2010;Hoeppner et al, 2009) and functional recovery (Tan et al, 2009). The porous nature and three-dimensional (3D) micro-architecture of SIS enable cells to adhere, grow and migrate (Badylak et al, 1999;Ferrand et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Quantification of MSCs involved in wound healing: use of SIS to transfer MSCs to wound site and quantification of MSCs involved in skin wound healing

Yeum

Park

Lee

et al. 2012

J Tissue Eng Regen Med

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Mesenchymal stem cells (MSCs) are known to be effective in wound healing, but not much has been reported on quantitative correlations between MSCs injected into the wound site and MSCs that actually participate in wound healing. This study traced MSCs participating in wound healing by using small intestinal submucosa (SIS) as a cell carrier, identified their moving path and calculated the number of MSCs involved in wound healing. First, MSCs were isolated from the nude mouse and 1 Â 10 6 cells were seeded onto the centre of the SIS. MSC-seeded SIS complexes were injected onto full-thickness skin wounds made on the dorsum of nude mice. Tracing of MSC-seeded SIS complex transplanted to the wound site revealed that 27.6% of the MSCs were migrated to the wound site at the first attempt. Second, repeated injection of additional MSCs did not increase the number of MSCs participating in wound healing beyond a certain constant maximum amount. The number of MSCs present in the wound site remains constant in the range 2-3 Â 10 5 from day 1 to day 10. The expression of skin regenerationrelated growth factors was confirmed by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). MSCs participating in wound healing were found not only to suppress inflammation of the wound but also to increase the skin regeneration-related growth factors that enable the recovery of the skin. An optimal number of about 3 Â 10 5 MSCs injected into the site was found to adapt themselves to the skin wound-healing process effectively.

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“…Xenogeneic porcine small intestinal submucosa (SIS) is a naturally occurring matrix complex of structural and functional proteins that has recently been successfully used as a scaffold for tissue repair of defects in hernias, 17 wounds, 18 bone, 19 meniscus, [20][21][22] and tendon 23 in animal models and as a pubourethral sling and paraesophageal patch in human clinical trials. 24,25 Specifically in regard to ligaments, recent animal studies used SIS as a filler implant in the gap of spinal ligament resections 26 and in the gap of a collateral ligament resection to support tissue ingrowth using a small animal model.…”

Section: Introductionmentioning

confidence: 99%

Metacarpophalangeal collateral ligament reconstruction using small intestinal submucosa in an equine model

Bertone

Goin

Kamei

et al. 2007

J Biomedical Materials Res

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Xenogeneic porcine small intestinal submucosa (SIS) is a natural, biodegradable matrix that has been successfully used as a scaffold for repair of tissue defects. The goal of this study was to compare a collateral ligament transection surgically reconstructed with an anchored SIS ligament to a sham-operated control procedure for the correction of joint laxity using an equine model. Ten metacarpophalangeal joints from 10 horses had complete transection of the lateral collateral ligament. In 6 horses, the collateral ligament was reconstructed with a multilaminate strip of SIS anchored with screws into bone tunnels proximal and distal to the joint. The sham controls had similar screws, but no SIS placed. Clinical compatibility and effectiveness were evaluated with lameness, incisional quality, and joint range of motion, circumference and laxity. Ligament structure and strength was quantified with serial high resolution ultrasound, histology, and mechanical testing at 8 weeks. Surgical repair with SIS eliminated joint laxity at surgery. SIS-treated joints had significantly less laxity than sham treatment at 8 weeks (p < 0.001). SIS-treated ligaments demonstrated a progressive increase in repair tissue density and fiber alignment that by week 8 were significantly greater than sham-treated ligament (p < 0.03). SIS-repaired ligament tended to have greater peak stress to failure than sham-treatment (p < 0.07). Cellularity within the ligament repair tissue and inflammation within the bone tunnel was significantly greater in the SIS-treated limbs (p < 0.017). Within the first 8 weeks of healing, SIS implanted to reinforce collateral ligament injury was biocompatible in the joint environment, restored initial loss of joint stability, and accelerated early repair tissue quality. SIS ligament reconstruction might provide benefit to early ligament healing and assist early joint stability associated with ligament injury.

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Meniscal tissue regeneration using a collagenous biomaterial derived from porcine small intestine submucosa

Cited by 76 publications

References 23 publications

Updates in biological therapies for knee injuries: menisci

Updates in biological therapies for knee injuries: menisci

Quantification of MSCs involved in wound healing: use of SIS to transfer MSCs to wound site and quantification of MSCs involved in skin wound healing

Metacarpophalangeal collateral ligament reconstruction using small intestinal submucosa in an equine model

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