Meningioangiomatosis without neurofibromatosis: a clinical analysis

Jallo, George I.; Kothbauer, Karl F.; Mehta, Vikas; Abbott, Rick; Epstein, Fred J.

doi:10.3171/ped.2005.103.4.0319

Cited by 17 publications

(32 citation statements)

References 31 publications

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“…Indeed MA have been associated with other lesions, including meningiomas 2,5,11,15,29 vascular malformation 8 , oligodendroglioma 14 , astrocytoma, ependymoma, and primitive neuroectodermal tumor 9 , schwannoma 8 and encephalocele.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…The seizure-free rates after lesionectomy are variably and may afford improvement in between 43-68% of the cases, but almost 70-80% of the patients continued to required antiepileptic drugs 8 . Its accurate diagnosis is important because total surgical removal is the treatment of choice, and after total excision; the lesion does not regrow 3,20,25 .…”

Section: Surgery Pathological Findings and Outcomementioning

confidence: 99%

“…The lesion can extend into the perivascular space but spares the white matter 8 . No pleomorphism, mitoses, necrosis, or cortical invasions are associated with it 6,20,28 .…”

Section: Surgery Pathological Findings and Outcomementioning

confidence: 99%

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Meningioangiomatosis: clinical-radiological features and surgical outcome

et al. 2010

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SummaryMeningioangiomatosis (MA) is a rare, benign neoplastic disorder involving the cortex and leptomeninges, the sporadic form, commonly presents as refractory localization-related epilepsy, but could be asymptomatic especially in older patients. The imaging features may be entirely non-specific. Magnetic Resonance Imaging (MRI) erroneously suggests meningioma, lowgrade tumour or vascular malformations.The pathological findings are characterised by proliferation of meningothelial cells and leptomeningeal vessels and calcifications within the mass. Macroscopically there is dense thickening in the underlying cortex, often in a sharply defined area.In this article we report 3 cases of MA, neither of whom had a familiary history or stigmata of Neurofibromatosis (NF). We discuss and place particular emphasis on the clinical presentation and diagnosis imaging, as well as on the outcome. We also review the literature concerning about the aetiology, pathology findings and imaging features of MA.KEY WORDS: Brain tumor. Histopathology. Meningioangiomatosis. Magnetic resonance imaging. Seizure. Meningioangiomatosis: características clínico-radioló-gicas y resultados quirúrgicos ResumenLa meningioangiomatosis (MA) es un proceso neoplásico benigno raro, que envuelve el córtex y leptomeninges, en su forma esporádica comúnmente se presenta con epilepsia refractaria, en relación a su localización, pero puede ser asintomática, especialmente en adultos mayores. Las características de imagen pueden ser totalmente inespecíficas. Las imágenes de resonancia magnética erróneamente sugieren la presencia de un meningioma, tumores de bajo grado, o malformaciones vasculares.Los hallazgos patológicos se caracterizan por la proliferación de células meningoteliales, vasos leptomeningeos y calcificaciones dentro del tumor. Macroscópicamente se observa un denso engrosamiento en el córtex adyacente, generalmente con un área claramente definida.En este articulo, se describen 3 casos de MA, ninguno de ellos presentaba historia familiar o estigmas de neurofibromatosis (NF). Nosotros realizamos la discusión, haciendo particular énfasis en la presentación clínica y diagnóstico por imágenes, así como en el pronóstico.

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Section: Differential Diagnosismentioning

confidence: 99%

Section: Surgery Pathological Findings and Outcomementioning

confidence: 99%

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Meningioangiomatosis: clinical-radiological features and surgical outcome

et al. 2010

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“…Meningioangiomatosis is an uncommon cortical lesion corresponding to a plaque-like proliferation of meningothelial and fibroblast-like cells surrounding small vessels, which occurs sporadically or in the spectrum of NF2 [6]. It is usually a single cortical lesion; however, multifocal non-cortical cases have been reported [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…It is usually a single cortical lesion; however, multifocal non-cortical cases have been reported [6,7]. Sporadic meningioangiomatosis is usually a single lesion occurring in young adults or children, who present with seizures or headache [6,8].…”

Section: Discussionmentioning

confidence: 99%

Meningioangiomatosis in a 5-Year-Old Boy Presenting with Intractable Seizures

Alexiou

Moschovi²,

Stefanaki³

et al. 2011

Pediatr Neurosurg

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A 5-year-old boy with a history of epilepsy underwent brain magnetic resonance imaging (MRI) because of an increase in seizure frequency. Brain MRI demonstrated a left frontal lesion. The patient was operated upon, and gross total excision was performed. The histological diagnosis was meningioangiomatosis. On follow-up examination 10 years later, the patient was free of seizures and without any evidence of tumor recurrence. Meningioangiomatosis is a rare benign hamartomatous lesion that is associated with seizures. Complete excision is associated with favorable long-term outcome. The novelty of the present case is the young age of the child at presentation and the curative role of surgery considering the long-term follow-up.

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Meningioma

The Genetics and Molecular Biology of Neural Tumors

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Meningioangiomatosis without neurofibromatosis: a clinical analysis

Abstract: The authors advocate a gross-total resection of meningioangiomatosis for the treatment of seizure disorder in this population.

Cited by 17 publications

References 31 publications

Meningioangiomatosis: clinical-radiological features and surgical outcome

Meningioangiomatosis: clinical-radiological features and surgical outcome

Meningioangiomatosis in a 5-Year-Old Boy Presenting with Intractable Seizures

Meningioma

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