Membrane-wrapped nanoparticles for photothermal cancer therapy

Abstract

Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is a minimally invasive treatment for solid-tumor cancers that has immense promise as a standalone therapy or adjuvant to other treatments like chemotherapy, immunotherapy, or radiotherapy. To maximize the success of photothermal therapy, light-responsive nanoparticles can be camouflaged with cell membranes to endow them with unique biointerfacing capabilities that reduce opsonization, prolong systemic circulation, and improve tumor delivery through enhanced passive accumulation or homotypic targeting. This ensures a sufficient dose of photoresponsive nanoparticles arrives at tumor sites to enable their complete thermal ablation. This review summarizes the state-of-the-art in cell membrane camouflaged nanoparticles for photothermal cancer therapy and provides insights to the path forward for clinical translation.

Immunogenic Cell Death Photothermally Mediated by Erythrocyte Membrane-Coated Magnetofluorescent Nanocarriers Improves Survival in Sarcoma Model

“…In effect, CMNPs have been explored for their potential in PTT, utilizing either near-infrared dyes or inorganic nanoparticles such as gold, copper sulfide, and iron oxide NPs [ 1 , 5 , 24 , 25 , 26 ]. Among the iron oxide NPs, magnetite is the most often used, while ICG is the primary choice for dye-based PTT [ 1 , 27 ]. Both have been approved for clinical use [ 6 ].…”

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

“…Light stimulation has the characteristics of non-invasiveness, flexible control of irradiation intensity and irradiation time. 316 Therefore, it has developed rapidly and has gradually formed unique treatment methods, such as photodynamic therapy (PDT) and photothermal therapy (PTT). PDT is a new type of therapy for treating diseases.…”

Antioxidant, Enzyme, and H2O2-Triggered Melanoma Targeted Mesoporous Organo-Silica Nanocomposites for Synergistic Cancer Therapy

“…To avoid drug leakage before reaching the cancer cells and cause serious toxicity to normal tissues, the cancer targeted stimuli-responsive nanocarriers have widely been exploited in various cancer treatments [ 8 , 9 , 10 ]. The single stimuli-responsive DDS exhibits an improved cellular uptake, high accumulation rates in cancer cells, and a controlled drug release in response to the specific internal or external stimuli, including the pH, redox potential, temperature, biomolecules, light, and magnetic field [ 10 , 11 , 12 , 13 ]. In addition, two or more stimuli-responsive nanocarriers not only include all of the advantages in a single responsive DDS, but also accelerate the drug release at the target site, leading to several-fold increased cancer therapeutic efficiency [ 14 , 15 , 16 ].…”