1998
DOI: 10.1523/jneurosci.18-17-06681.1998
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Abstract: When neurons undergo dramatic shape and volume changes, how is surface area adjusted appropriately? The membrane tension hypothesis-namely that high tensions favor recruitment of membrane to the surface whereas low tensions favor retrieval-provides a simple conceptual framework for surface area homeostasis. With membrane tension and area in a feedback loop, tension extremes may be averted even during excessive mechanical load variations. We tested this by measuring apparent membrane tension of swelling and shr… Show more

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Cited by 226 publications
(249 citation statements)
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“…Investigators have reported lipid insertion as a protective mechanism against high membrane tension (7,34,61), similar to behavior we have previously reported for alveolar epithelial cells undergoing tonic stretch (18). Investigators have also pointed to ruffled plasma membranes as protection against membrane lysis in case of rapid deformation (31,57).…”
supporting
confidence: 83%
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“…Investigators have reported lipid insertion as a protective mechanism against high membrane tension (7,34,61), similar to behavior we have previously reported for alveolar epithelial cells undergoing tonic stretch (18). Investigators have also pointed to ruffled plasma membranes as protection against membrane lysis in case of rapid deformation (31,57).…”
supporting
confidence: 83%
“…3, however, is incomplete because it predicts that lipid insertion can produce complete membrane relaxation, allowing tension to diminish to zero under constant deformation. Contrary to this prediction, investigators have found that tension did relax partially after increasing with deformation in osmotically swollen cells, but it did not disappear completely (7,8). Furthermore, they found that a released cell, even after lipids have been added, still recovered its initial shape and size (6,7).…”
mentioning
confidence: 86%
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