Membrane Permeation versus Amyloidogenicity: A Multitechnique Study of Islet Amyloid Polypeptide Interaction with Model Membranes

Martel, Anne; Antony, Lucas; Gerelli, Yuri; Porcar, Lionel; Fluitt, Aaron M.; Hoffmann, Kyle Q.; Kiesel, Irena; Vivaudou, Michel; Fragneto, Giovanna; Pablo, Juan J. de

doi:10.1021/jacs.6b06985

Cited by 53 publications

(63 citation statements)

References 66 publications

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“…IAPP or amylin is a polypeptide pancreatic hormone formed by 37 amino acids, and it is synthetized, stored, and secreted with insulin by the PBC of the islets of Langerhans, although its synthesis has also been described in the gastric endocrine cells. Since it is cosecreted with insulin, it is to be expected that both hormones share the same stimuli for their release [ 114 ].…”

Section: Apoptosis Mediated By Endoplasmic Reticulum Stress: Rolementioning

confidence: 99%

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

Rojas

Bermúdez

Palmar

et al. 2018

Journal of Diabetes Research

132

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Purpose of ReviewDescribing the diverse molecular mechanisms (particularly immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 diabetes mellitus. Recent FindingsBeta cell death is the final event in a series of mechanisms that, up to date, have not been entirely clarified; it represents the pathophysiological mechanism in the natural history of diabetes mellitus. These mechanisms are not limited to an apoptotic process only, which is characteristic of the immune-mediated insulitis in type 1 diabetes mellitus. They also include the action of proinflammatory cytokines, the production of reactive oxygen species, DNA fragmentation (typical of necroptosis in type 1 diabetic patients), excessive production of islet amyloid polypeptide with the consequent endoplasmic reticulum stress, disruption in autophagy mechanisms, and protein complex formation, such as the inflammasome, capable of increasing oxidative stress produced by mitochondrial damage. SummaryNecroptosis, autophagy, and pyroptosis are molecular mechanisms that modulate the survival of the pancreatic beta cell, demonstrating the importance of the immune system in glucolipotoxicity processes and the potential role for immunometabolism as another component of what once known as the “ominous octet.”

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Section: Apoptosis Mediated By Endoplasmic Reticulum Stress: Rolementioning

confidence: 99%

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

Rojas

Bermúdez

Palmar

et al. 2018

Journal of Diabetes Research

132

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“…Nevertheless, simpler model systems can be implemented to extract selective structural information on a few lipid species and probe their potential interaction within the membrane or with proteins. Today, most of the simpler models focus on the main mammalian lipid phosphatidylcholine (PC) and some charged species such as phosphatidylserine (PS) or phosphatidylglycerol (PG) and sterols [15][16][17]. In this context, supported lipid bilayers (SLBs), are particularly relevant as they provide a stable flat structure and a highly tuneable composition, which make them optimal candidates for many different kinds of experiments involving surface-sensitive techniques [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Towards biomimics of cell membranes: Structural effect of phosphatidylinositol triphosphate (PIP3) on a lipid bilayer

Luchini

Nzulumike

Lind

et al. 2019

Colloids and Surfaces B: Biointerfaces

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“…The presence of calcium ions has been shown to promote human-IAPP aggregation and membrane fragmentation via a carpet-like mechanism [94]. For more details on the biological properties of IAPP, we refer readers to studies reported in the literature [132–138]. …”

Section: Protein Aggregation and Amyloid Formation In A Membrane Envimentioning

confidence: 99%

Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy

Naito

Matsumori

Ramamoorthy

2018

Biochimica et Biophysica Acta (BBA) - General Subjects

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A variety of biomolecules acting on the cell membrane folds into a biologically active structure in the membrane environment. It is, therefore, important to determine the structures and dynamics of such biomolecules in a membrane environment. While several biophysical techniques are used to obtain low-resolution information, solid-state NMR spectroscopy is one of the most powerful means for determining the structure and dynamics of membrane bound biomolecules such as antibacterial biomolecules and amyloidogenic proteins; unlike X-ray crystallography and solution NMR spectroscopy, applications of solid-state NMR spectroscopy are not limited by non-crystalline, non-soluble nature or molecular size of membrane-associated biomolecules. This review article focuses on the applications of solid-state NMR techniques to study a few selected antibacterial and amyloid peptides. Solid-state NMR studies revealing the membrane inserted bent α-helical structure associated with the hemolytic activity of bee venom melittin and the chemical shift oscillation analysis used to determine the transmembrane structure (with α-helix and 3-helix in the N- and C-termini, respectively) of antibiotic peptide alamethicin are discussed in detail. Oligomerization of an amyloidogenic islet amyloid polypeptide (IAPP, or also known as amylin) resulting from its aggregation in a membrane environment, molecular interactions of the antifungal natural product amphotericin B with ergosterol in lipid bilayers, and the mechanism of lipid raft formation by sphingomyelin studied using solid state NMR methods are also discussed in this review article. This article is part of a Special Issue entitled "Biophysical Exploration of Dynamical Ordering of Biomolecular Systems" edited by Dr. Koichi Kato.

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Membrane Permeation versus Amyloidogenicity: A Multitechnique Study of Islet Amyloid Polypeptide Interaction with Model Membranes

Cited by 53 publications

References 66 publications

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

Towards biomimics of cell membranes: Structural effect of phosphatidylinositol triphosphate (PIP3) on a lipid bilayer

Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy

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