Membrane fusion: A new function of non steroidal anti-inflammatory drugs

Chakraborty, Hirak; Mondal, Sutapa; Sarkar, Munna

doi:10.1016/j.bpc.2008.06.007

Cited by 41 publications

(47 citation statements)

References 36 publications

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“…Even though there exists a correlation between molecular dimension and concentration of destabilization, it is not the only decisive factor. Molecules having similar dimension like ibuprofen (Figure 12) do not show fusion [115]. …”

Section: Discussionmentioning

confidence: 99%

“…These drugs were originally developed to combat pain and inflammation but have been shown to have other functions as chemopreventive and chemosupressive agents [112–114]. Three drugs belonging to the oxicam groups of NSAIDs, namely, meloxicam, piroxicam, and tenoxicam (Figure 10) are found to act as membrane fusogens [115]. They are effective fusogens not only for membrane mimetics like lipid vesicles, but also for biomembranes like mitochondrial membrane.…”

Section: Fusion Induced By Different Fusogenic Agentsmentioning

confidence: 99%

“…A closer look showed that membrane fusion is not a property of piroxicam alone but is also shared by two other oxicam painkillers, namely, meloxicam and tenoxicam [115]. The three drugs can induce membrane fusion at physiologically relevant concentration [117] whereas NSAIDs belonging to other chemical groups do not share this property.…”

Section: Fusion Induced By Different Fusogenic Agentsmentioning

confidence: 99%

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Membrane Fusion Induced by Small Molecules and Ions

Roy

Sarkar

2011

Journal of Lipids

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Membrane fusion is a key event in many biological processes. These processes are controlled by various fusogenic agents of which proteins and peptides from the principal group. The fusion process is characterized by three major steps, namely, inter membrane contact, lipid mixing forming the intermediate step, pore opening and finally mixing of inner contents of the cells/vesicles. These steps are governed by energy barriers, which need to be overcome to complete fusion. Structural reorganization of big molecules like proteins/peptides, supplies the required driving force to overcome the energy barrier of the different intermediate steps. Small molecules/ions do not share this advantage. Hence fusion induced by small molecules/ions is expected to be different from that induced by proteins/peptides. Although several reviews exist on membrane fusion, no recent review is devoted solely to small moleculs/ions induced membrane fusion. Here we intend to present, how a variety of small molecules/ions act as independent fusogens. The detailed mechanism of some are well understood but for many it is still an unanswered question. Clearer understanding of how a particular small molecule can control fusion will open up a vista to use these moleucles instead of proteins/peptides to induce fusion both in vivo and in vitro fusion processes.

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Section: Discussionmentioning

confidence: 99%

Section: Fusion Induced By Different Fusogenic Agentsmentioning

confidence: 99%

Section: Fusion Induced By Different Fusogenic Agentsmentioning

confidence: 99%

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Membrane Fusion Induced by Small Molecules and Ions

Roy

Sarkar

2011

Journal of Lipids

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“…[1,2]. Some of these NSAIDs also have interesting spectroscopic properties that are sensitive to their microenvironment and can be used effectively as reporter of their interaction with biomolecules [3][4][5].…”

Section: Introductionmentioning

confidence: 98%

A traditional painkiller as a probe for microheterogeneity in 1-propanol–water mixtures

Chakraborty

Sehanobish

Sarkar

2010

Chemical Physics Letters

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“…[8,9] IMC is also used as a primary medicine for relief pain, to reduce fever, swelling and stiffness, and to prevent tumour growth. [10] This drug molecule also has a significant impact on the human body, and can be used for gastrointestinal disorders and anticancer activity, [10] as a protective agent against neurodegeneration disease such as Alzheimer disease, [11] as an inducer of membrane fusion, [12] and it also has platelet-inhibitory actions. [13] IMC also acts as a potent inhibitor of the cyclooxygenase enzyme (COX-1 and COX-2).…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

et al. 2014

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Supramolecular host-guest complexation between the nonsteroidal anti-inflammatory drug indomethacin (IMC) and molecular containers were investigated. The weakly fluorescent drug molecule becomes highly fluorescent on complexation with different molecular containers, and time-resolved fluorescence emission spectroscopy reveals that the lifetime components of IMC significantly increase in the presence of molecular containers, compared with the lifetimes in neat water. The respective solid host-guest complexes were synthesised and characterised by Fourier transform infrared and (1) H nuclear magnetic resonance spectroscopic analysis. Microscopy techniques were used to analyse modifications of the surface morphology, owing to the formation of supramolecular complexes. The effect of the molecular container on the optical properties of IMC has also been investigated to determine the effect of nanochannels of different size and structure.

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Membrane fusion: A new function of non steroidal anti-inflammatory drugs

Cited by 41 publications

References 36 publications

Membrane Fusion Induced by Small Molecules and Ions

Membrane Fusion Induced by Small Molecules and Ions

A traditional painkiller as a probe for microheterogeneity in 1-propanol–water mixtures

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

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