Meloxicam-LDH Hybrid Compound: A Successful Strategy to Improve Solubility

Monteforte, Francesco; Bruni, Giovanna; Quinzeni, Irene; Friuli, Valeria; Maggi, Lauretta; Capsoni, Doretta; Bini, Marcella

doi:10.1007/s10904-019-01230-z

Cited by 11 publications

(18 citation statements)

References 27 publications

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“…The LDH pattern shows the reflections expected for a layered material, which agree with those of the reference hydrotalcite pattern [ 31 ]. The most intense peaks are those of the basal diffraction of 00l reflections of LDHs , with the NO 3 − as intercalated anions, due to the employed reagents.…”

Section: Resultssupporting

confidence: 74%

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Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

et al. 2023

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The search for effective systems to facilitate the release of poorly bioavailable drugs is a forefront topic for the pharmaceutical market. Materials constituted by inorganic matrices and drugs represent one of the latest research strategies in the development of new drug alternatives. Our aim was to obtain hybrid nanocomposites of Tenoxicam, an insoluble nonsteroidal anti-inflammatory drug, with both layered double hydroxides (LDHs) and hydroxyapatite (HAP). The physicochemical characterization on the base of X-ray powder diffraction, SEM/EDS, DSC and FT-IR measurements was useful to verify the possible hybrids formation. In both cases, the hybrids formed, but it seemed that the drug intercalation in LDH was low and, in fact, the hybrid was not effective in improving the pharmacokinetic properties of the drug alone. On the contrary, the HAP–Tenoxicam hybrid, compared to the drug alone and to a simple physical mixture, showed an excellent improvement in wettability and solubility and a very significant increase in the release rate in all the tested biorelevant fluids. It delivers the entire daily dose of 20 mg in about 10 min.

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Section: Resultssupporting

confidence: 74%

“…Tnx ( Figure 2 a) is constituted by particles of irregular shapes with variable dimensions, up to about 10 μm. LDH ( Figure 2 b) is formed by aggregates of small particles, with a flat shape, as expected for layered compounds [ 31 ]. The LDH-T morphology ( Figure 2 c) is different from both the drug and LDH .…”

Section: Resultsmentioning

confidence: 92%

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

et al. 2023

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“…In some cases, the basal spacing between the layers can vary widely depending on the size of the guest 7 which allows a variety of species, such as drugs, to be intercalated. Intercalation of drugs into a layered material can be achieved by several routesmost commonly by ion exchange (diffusion of drug ions from solution into the interlayer space) [8][9][10][11] and co-precipitation (synthesis in the presence of neutral or ionic drug species), [12][13][14][15] but also reconstruction (calcination and reaction with drug solution), 16,17 and exfoliationreassembly (separation of layered material into sheets, and reassembly in drug solution). 18,19 There exist many layered systems which are comprised of negatively charged layers and are therefore cation-exchangeable, for example metal oxides, 20 metal phosphates, 21 and aluminophosphates.…”

Section: Introductionmentioning

confidence: 99%

Layered terbium hydroxides for simultaneous drug delivery and imaging

et al. 2021

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“…The XRD patterns of Mlx, HAP and HAP-Mlx are compared in Figure 1A, and those of Mlx, HAP-Mg and HAP-Mg-Mlx are compared in Figure 1B. The pattern of Mlx shows well-defined peaks typical of a crystalline drug that possesses the polymorphic Form I [9,12]. The pure hydroxyapatite obtained from the coprecipitation method (Figure 1A) showed the typical pattern of the hexagonal structure with the main peaks in the 30 and 35° 2θ angular range [22].…”

Section: Xrd and Rietveld Resultsmentioning

confidence: 99%

Physicochemical Characterization of Hydroxyapatite Hybrids with Meloxicam for Dissolution Rate Improvement

Maggi,

Friuli,

Cerea

et al. 2024

Molecules

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Organic–inorganic hybrids represent a good solution to improve the solubility and dissolution rates of poorly soluble drugs whose number has been increasing in the last few years. One of the most diffused inorganic matrices is hydroxyapatite (HAP), which is a biocompatible and osteoconductive material. However, the understanding of the hybrids’ functioning mechanisms is in many cases limited; thus, thorough physicochemical characterizations are needed. In the present paper, we prepared hybrids of pure and Mg-doped hydroxyapatite with meloxicam, a drug pertaining to the Biopharmaceutical Classification System (BCS) class II, i.e., drugs with low solubility and high permeability. The hybrids’ formation was demonstrated by FT-IR, which suggested electrostatic interactions between HAP and drug. The substitution of Mg in the HAP structure mainly produced a structural disorder and a reduction in crystallite sizes. The surface area of HAP increased after Mg doping from 82 to 103 m2g−1 as well as the pore volume, justifying the slightly high drug amount adsorbed by the Mg hybrid. Notwithstanding the low drug loading on the hybrids, the solubility, dissolution profiles and wettability markedly improved with respect to the drug alone, particularly for the Mg doped one, which was probably due to the main distribution of the drug on the HAP surface.

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Meloxicam-LDH Hybrid Compound: A Successful Strategy to Improve Solubility

Cited by 11 publications

References 27 publications

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

Layered terbium hydroxides for simultaneous drug delivery and imaging

Physicochemical Characterization of Hydroxyapatite Hybrids with Meloxicam for Dissolution Rate Improvement

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