Meleagrin from marine fungus <i>Emericella dentata</i> Nq45: crystal structure and diverse biological activity studies

Hamed, Abdelaaty; Abdel‐Razek, Ahmed S.; Araby, Mariam; Abu-Elghait, Mohammed; El-Hosari, Doaa G.; Frese, Marcel; Soliman, Hesham S. M.; Stammler, Hans Georg; Sewald, Norbert; Shaaban, Mohamed

doi:10.1080/14786419.2020.1741583

Cited by 38 publications

(26 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…693) against the human cervix carcinoma cell line KB-3-1 and its multi-drug-resistant sub-clone KB-V1, meleagrin (Cpd. 693) was cytotoxic to cells with IC 50 values of 3.07 and 6.07 µM, respectively ( Table S6 ) [ 114 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

et al. 2021

View full text Add to dashboard Cite

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.

show abstract

Section: Resultsmentioning

confidence: 99%

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Finally, meleagrin A ( 8 ), isolated from CIGOM 10, showed partial inhibition against MSSA at the highest concentration tested ( Table 4 ). In previous studies, this compound demonstrated antibiofilm activity vs. S. aureus ATCC 29213, with 87.1% of inhibition at 69.2 µM [ 39 ]. It also inhibited FabI, an isoform of enoyl-ACP reductase that participates in the fatty acid biosynthesis in multidrug-resistant bacteria [ 40 ], and antimicrobial activity against different microorganisms in the paper-disk diffusion assay [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…In previous studies, this compound demonstrated antibiofilm activity vs. S. aureus ATCC 29213, with 87.1% of inhibition at 69.2 µM [ 39 ]. It also inhibited FabI, an isoform of enoyl-ACP reductase that participates in the fatty acid biosynthesis in multidrug-resistant bacteria [ 40 ], and antimicrobial activity against different microorganisms in the paper-disk diffusion assay [ 39 ]. Lastly, this compound was weakly active against Micrococcus luteus DSMZ 1605 [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…It also inhibited FabI, an isoform of enoyl-ACP reductase that participates in the fatty acid biosynthesis in multidrug-resistant bacteria [ 40 ], and antimicrobial activity against different microorganisms in the paper-disk diffusion assay [ 39 ]. Lastly, this compound was weakly active against Micrococcus luteus DSMZ 1605 [ 39 ]. In our assays, meleagrin A ( 8 ) displayed anti- M. tuberculosis and M avium activity with MIC of 48.0 and 12.3 μM, respectively, and no cytotoxic activity against Vero cell line was observed ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Diversity and Antimicrobial Potential of Cultivable Fungi from Deep-Sea Sediments of the Gulf of Mexico

et al. 2021

View full text Add to dashboard Cite

A collection of 29 cultivable fungal strains isolated from deep-sea sediments of the Gulf of Mexico were cultivated under the “one strain, many compounds” approach to explore their chemical diversity and antimicrobial potential. From the 87 extracts tested, over 50% showed antimicrobial activity, and the most active ones were those from cultures grown at 4 °C in darkness for 60 days (resembling deep-sea temperature). PCA analysis of the LC-MS data of all the extracts confirmed that culture temperature is the primary factor in the variation of the 4462 metabolite features, accounting for 21.3% of the variation. The bioactivity-guided and conventional chemical studies of selected fungal strains allowed the identification of several active and specialized metabolites. Finally, metabolomics analysis by GNPS molecular networking and manual dereplication revealed the biosynthetic potential of these species to produce interesting chemistry. This work uncovers the chemical and biological study of marine-derived fungal strains from deep-sea sediments of the Gulf of Mexico.

show abstract

“…The antimicrobial activity of ESFE was determined by Agar diffusion assay [18,19]. Muller-Hinton agar (MHA) (Oxoid, Hampshire, UK) and Tryptic soy agar (TSA) (Oxoid, Hampshire, UK) media were used to evaluate the growth of the tested bacterial and yeast strains.…”

Section: Anti-microbial Assaymentioning

confidence: 99%

HPLC-PDA-ESI-MS/MS Profiling and Anti-Biofilm Potential of Eucalyptussideroxylon Flowers

et al. 2021

Self Cite

View full text Add to dashboard Cite

The development of multidrug-resistant bacterial strains is a worldwide emerging problem that needs a global solution. Exploring new natural antibiofilm agents is one of the most important alternative therapies in combating bacterial infections. This study aimed at testing the antimicrobial potential of Eucalyptus sideroxylon flowers extract (ESFE) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans prior to testing the antibiofilm activity against S. aureus, P. aeruginosa and C. albicans. ESFE demonstrated antimicrobial activity and promising inhibition activity against methicillin-resistant S. aureus (MRSA) biofilm formation up to 95.9% (p < 0.05) at a concentration of 0.05 mg/mL and eradicated C. albicans biofilm formation up to 71.2% (p < 0.05) at a concentration of 0.7 mg/mL. LC-MS analysis allowed the tentative identification of eighty-three secondary metabolites: 21 phloroglucinol, 18 terpenes, 16 flavonoids, 7 oleuropeic acid derivatives, 7 ellagic acid derivatives, 6 gallic acid derivatives, 3 phenolic acids, 3 fatty acids and 2 miscellaneous. In conclusion, E. sideroxylon is a rich source of effective constituents that promote its valorization as a promising candidate in the management of multidrug-resistant bacterial infections.

show abstract

Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies

Cited by 38 publications

References 26 publications

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

Chemical Diversity and Antimicrobial Potential of Cultivable Fungi from Deep-Sea Sediments of the Gulf of Mexico

HPLC-PDA-ESI-MS/MS Profiling and Anti-Biofilm Potential of Eucalyptussideroxylon Flowers

Contact Info

Product

Resources

About