2014
DOI: 10.1111/jpi.12161
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Abstract: Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion (MI/R) injury by reducing oxidative stress. Activation of silent information regulator 1 (SIRT1) signaling also reduces MI/R injury. We hypothesize that melatonin may protect against MI/R injury by activating SIRT1 signaling. This study investigated the protective effect of melatonin treatment on MI/R heart and elucidated its potential mechanisms. Rats were exposed to melatonin treatment in the presence or the absence of the mela… Show more

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Cited by 176 publications
(181 citation statements)
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“…After the end of the reperfusion, blood samples (0.5 mL) were drawn and total serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities were measured spectrophotometrically (Beckman DU 640, Fullerton, CA, USA) in a blinded manner as described before [29] . All kits for measuring LDH and CK activities were purchased from the Institute of Jiancheng Bioengineering (Nanjing, China).…”
Section: Determination Of Total Serum Ldh and Ckmentioning
confidence: 99%
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“…After the end of the reperfusion, blood samples (0.5 mL) were drawn and total serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities were measured spectrophotometrically (Beckman DU 640, Fullerton, CA, USA) in a blinded manner as described before [29] . All kits for measuring LDH and CK activities were purchased from the Institute of Jiancheng Bioengineering (Nanjing, China).…”
Section: Determination Of Total Serum Ldh and Ckmentioning
confidence: 99%
“…Echocardiography was performed 24 h after reperfusion as previously described [29] . Briefly, the rats were sedated (2% isoflurane) and studied using a VEVO 770 high-resolution in vivo imaging system (Visual Sonics, Toronto, Canada).…”
Section: Cardiac Function Measurementmentioning
confidence: 99%
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“…Serum CK and LDH levels were spectrophotometrically measured (Beckman DU 640, Fullerton, CA, USA) according to the manufacturer's instructions [34] .…”
Section: Acta Pharmacologica Sinicamentioning
confidence: 99%