volume 10, issue 10, P2954-2972 2018
DOI: 10.18632/aging.101602
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Jia Fang, Yuan Yan, Xin Teng, Xinyu Wen, Na Li, Sha Peng, Wenshuai Liu, F. Xavier Donadeu, Shanting Zhao, Jinlian Hua

Abstract: Transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can aid in the treatment of numerous diseases in animals. However, natural aging during in vitro expansion of ADMSCs prior to their use in transplantation restricts their beneficial effects. Melatonin is reported to exert biorhythm regulation, anti-oxidation, and anti-senescence effects in various animal and cell models. Herein, by using a senescent canine ADMSCs (cADMSCs) cell model subjected to multiple passages in vitro, we investigated the …

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