Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes

Cheikh, Mohamed; Makhlouf, Khouloud; Ghattassi, Kais; Graja, Ahmed; Ferchichi, Salima; Kallel, Choumous; Houda, Mallek; Souissi, Nizar

doi:10.1080/07420528.2019.1692348

Cited by 16 publications

(45 citation statements)

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“…Taking into consideration that lactate dehydrogenase (LDH) provides information about muscle metabolism, examination of LDH responses could help coaches and physicians identify the appropriate level of training and the type of metabolic adaptation to exercise [ 14 ]. In this context, it is well known that CK, LDH, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) are markers of muscle and liver damages and fatigue during exercise [ 10 ]; it has been reported that these parameters are increased immediately after the Wingate test [ 15 , 16 , 17 ], repeated sprint exercise [ 1 , 18 , 19 , 20 , 21 , 22 , 23 ], the Yo-Yo intermittent recovery test [ 24 ], a training session [ 10 ], or competitions [ 25 , 26 , 27 ]. Additionally, after long-duration exercise, Hammouda et al [ 24 ] showed increases in muscle damage markers (i.e., CK and LDH) 3 min after the level−1 Yo-Yo intermittent recovery test, confirming higher anaerobic solicitation of the test.…”

Section: Introductionmentioning

confidence: 99%

Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes

Boukhris

Trabelsi

Abdessalem

et al. 2020

IJERPH

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Physical exercise is often associated with increases in muscle damage markers and inflammation. However, biomarkers of muscle damage and inflammation responses to the 5-m shuttle run test (5mSRT) have not yet been evaluated. The aim of the present study was to investigate effects of the 5mSRT on muscle damage markers, inflammation, and perception of fatigue and recovery in healthy male athletes. Fifteen male amateur team sports players (age: 20 ± 3 yrs, height: 173 ± 7 cm, body-mass: 67 ± 7 kg) participated in this study. Blood biomarkers were collected at rest, 5 min after, and 72 h after the 5mSRT to measure muscle damage (i.e., creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT)) and inflammation (i.e., C-reactive protein (CRP)). Best distance (BD), total distance (TD), fatigue index (FI), and percentage decrement (PD) during the 5mSRT were assessed. Perceived recovery (PRS) and delayed onset muscle soreness (DOMS) were recorded before, 5 min after, and 72 h after the 5mSRT; perceived exertion (RPE) was recorded before, during, and 72 h after the 5mSRT. Muscle damage biomarkers post 5mSRT showed a significant increase compared to pre 5mSRT (p < 0.001) levels ((i.e., CK (190.6 ± 109.1 IU/L vs. 234.6 ± 113.7 IU/L), LDH (163.6 ± 35.1 IU/L vs. 209.9 ± 50.8 IU/L), ASAT (18.0 ± 4.4 IU/L vs. 21.7 ± 6.2 IU/L), and ALAT (10.2 ± 3.4 IU/L vs. 12.7 ± 3.8 IU/L)) and 72 h post 5mSRT (p < 0.001) levels ((CK (125.3 ± 80.5 IU/L vs. 234.6 ± 113.7 IU/L), LDH (143.9 ± 36.6 IU/L vs. 209.9 ± 50.8 IU/L), ASAT (15.0 ± 4.7 IU/L vs. 21.7 ± 6.2 IU/L), and ALAT (8.6 ± 2.4 IU/L vs. 12.7 ± 3.8 IU/L)). CRP was also significantly higher post 5mSRT compared to pre 5mSRT (2.1 ± 2.5 mg/L vs. 2.8 ± 3.3 mg/L, p < 0.001) and 72 h post 5mSRT (1.4 ± 2.3 mg/L vs. 2.8 ± 3.3 mg/L, p < 0.001). Significant correlations were reported between (i) physical performance parameters (i.e., PD, FI, TD, and BD), and (ii) markers of muscle damage (i.e., CK, LDH, ASAT, and ALAT) and inflammation (i.e., CRP). Similarly, DOMS and RPE scores were significantly higher post 5mSRT compared to pre 5mSRT (2.4 ± 1.0UA vs. 6.7 ± 1.1UA and 2.1 ± 0.6 UA vs. 8.1 ± 0.6 UA, respectively p < 0.001) and 72 h post 5mSRT (1.9 ± 0.7 UA vs. 6.7 ± 1.1 UA and 1.5 ± 0.6 UA vs. 8.1 ± 0.6 UA, respectively p < 0.001). PRS scores were significantly lower post 5mSRT as compared to pre 5mSRT (6 ± 1 UA vs. 3 ± 1 UA, p < 0.001) and 72 h post 5mSRT (7 ± 1 UA vs. 3 ± 1 UA, p < 0.001). Significant correlations existed between (i) performance parameters (PD, FI, TD, and BD) and (ii) RPE, PRS, and DOMS. The 5mSRT increased biomarkers of muscle damage and inflammation, as well as the DOMS and RPE and reduced the PRS. Seventy-two hours was sufficient for fatigue recovery induced by the 5mSRT. PD is better than FI for the calculation of performance decrements during the 5mSRT to represent fatigue.

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Section: Introductionmentioning

confidence: 99%

Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes

Boukhris

Trabelsi

Abdessalem

et al. 2020

IJERPH

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“…Increased serum MT level in footballers and in rowers after a 30-day MT intake. Reduced OS markers: MDA, IL-6, CRP, and low-density lipoproteins Supplementation of MT in professional athletes during intense training may protect against the toxic action of ROS/RNS and inflammation Souissi et al 2018 [ 121 ] Eight healthy moderately trained male students, mean age: 21.8 ± 0.9 years 6 mg MT supplementation or placebo at 09:00 a.m. in a randomized order 50 min before exercise Running at 60% for 45 min on a treadmill, starting at a speed of 8 km/h and increasing by 0.5 km/h after every minute Exercise elevated inflammatory markers: CRP, LDH, ALAT, ASAT in both placebo or MT intake groups MT ingestion before moderate prolonged submaximal exercise showed no anti-inflammatory action Cheikh et al 2020 [ 124 ] Randomized double-blind trial of 14 healthy-trained male athletes, mean age 154 ± 0.3 years 10 mg MT or placebo ingestion (control) after vigorous late-evening exercise (10:00 p.m.) Two-test sessions (separated at least one week) Running-Based Anaerobic Sprint Test at 8:00 p.m. and in the following morning (7:30 a.m.) Reductions of: WBC, NE, LY, CRP, muscle and hepatic damage enzymes (CK, ASAD), LDH, MDA and homocysteine before and after strenuous exercise vs placebo group MT intake after strenuous late-evening exercise diminished transient leukocytosis and protected against lipid peroxidation and muscle damage in teenage athletes Farjallach et al 2019 [ 125 ] 20 soccer players mean age 18.81 ± 1.3 years, MT group ( n = 10), placebo group ( n = 10) Nocturnal oral MT (5 mg) or placebo ingestion in a double-blind manner Intensive 6-day training-repeated sprint ability test: sprints 6 × 40 m with a 20 s of passive recovery between repetitions Decreased resting OS markers: AOPP, leukocytosis and CK. Decreased post-exercise leukocytosis and markers of cellular damage (CK, ASAT, ALAT), increased GPx and GR activities in MT-treated group vs placebo group Nocturnal MT intake during intensive training decreased OS, leukocytosis, cellular damage, and improved exercise performance LY lymphocytes, WBC white blood cells, NE neutrophils, CRP C-reactive protein, CK creatine kinase, LDH lactate dehydrogenase, ASAT aspartate aminotransferase, MDA malonaldehyde, LDL low-density lipoprotein, maximal oxygen uptake, ALAT alanine aminotransferase, CHO formaldehyde, ORAC oxygen radical absorption capacity, LPO ...…”

Section: Role Of Melatonin Supplementation In Response To Exercise-induced Oxidative Stressmentioning

confidence: 99%

Exercise-induced oxidative stress and melatonin supplementation: current evidence

2021

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Melatonin possesses the indoleamine structure and exerts antioxidant and anti-inflammatory actions and other physiological properties. Physical exercise can influence secretion of melatonin. Melatonin is used as a natural supplement among athletes to regulate sleep cycles and protect muscles against oxidative damage. Despite decades of research, there is still a lack of a comprehensive and critical review on melatonin supplementation and physical activity relationship. The aim of this literature review is to examine the antioxidant, anti-inflammatory and other biological functions played by melatonin with reference to the effect of physical exercise on melatonin secretion and the effect of this compound supplementation on exercise-induced oxidative stress in athletes. Evidence shows that intense exercises disturb antioxidant status of competitive athletes, whereas supplementation with melatonin strengthens antioxidant status in trained athletes in various sports as the compound showed high potency in reduction of the oxidative stress and inflammation markers generated during intense and prolonged exercise.

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“…This indoleamine is mainly produced by the pineal gland at night and is responsible for the synchronization of various physiological processes [7]. It directly scavenges ROS and protects against lipid peroxidation, protein oxidation and DNA damage [8]. It manifests indirect antioxidant properties by stimulating the enzymatic antioxidant system and producing molecules protecting against the deleterious effects of oxidative stress [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…It directly scavenges ROS and protects against lipid peroxidation, protein oxidation and DNA damage [8]. It manifests indirect antioxidant properties by stimulating the enzymatic antioxidant system and producing molecules protecting against the deleterious effects of oxidative stress [8,9]. Furthermore, it reveals promising results in the prevention and reduction of inflammation [8,10].…”

Section: Introductionmentioning

confidence: 99%

“…It manifests indirect antioxidant properties by stimulating the enzymatic antioxidant system and producing molecules protecting against the deleterious effects of oxidative stress [8,9]. Furthermore, it reveals promising results in the prevention and reduction of inflammation [8,10]. Likewise, it reduces muscle damage [8,10] and has a beneficial impact on skeletal muscle healing and tissue repair [11].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

et al. 2022

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Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was to determine the effect of melatonin supplementation during an intensive training period on physical performance decline, oxidative stress and cellular damage state. The investigation was conducted on 20 soccer players who participated in an exhaustive six-day training schedule associated with daily 5 mg oral melatonin or placebo ingestion. Resting blood samples and physical performance were measured before and after the training period. The mixed 2-way ANOVA (group x training camp) showed that compared to placebo, melatonin intake prevented an increase in advanced oxidation protein products (p>0.05) and increased the antioxidant enzyme activity (i.e., superoxide dismutase; p<0.001). In addition, melatonin prevented an increase of biomarkers of renal function (e.g., creatinine; p>0.05) and biomarkers of muscle (e.g., creatine kinase; p>0.05) and liver (e.g., gamma-glutamyltransferase; p>0.05) damage. Furthermore, melatonin alleviated the deterioration in physical performance (countermovement jump, five-jump test and 20-m sprint; p>0.05). In conclusion, the obtained data showed increased oxidative stress and renal, muscle and liver damage in professional soccer players during an exhaustive training schedule. Melatonin intake during the training period exerts beneficial effects on physical performance and protects tissues against the deleterious effects of reactive oxygen species and cellular damage.

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Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes

Cited by 16 publications

References 61 publications

Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes

Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes

Exercise-induced oxidative stress and melatonin supplementation: current evidence

Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

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