Melatonin: functions and ligands

Singh, Mahaveer; Jadhav, Hemant R.

doi:10.1016/j.drudis.2014.04.014

Cited by 185 publications

(177 citation statements)

References 83 publications

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“…Para além de ajustar o calendário do relógio, luz brilhante tem um outro efeito. Esta inibe diretamente a liberação de melatonina (SINGH;JADHAV, 2014;KAPPEN et al 2014).…”

Section: Ciclo Circadianounclassified

O Bem-Estar De Cães Na Prática Hospitalar

Aguiar¹,

Ribeiro²,

Balda³

et al. 2017

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RESUMOOs animais são seres sencientes, com sistemas biológico e psicológico complexos e necessidades específicas que, em conjunto, determinam seu grau de bem-estar. Assim, a prática hospitalar veterinária deve considerar as liberdades, oportunidades e necessidades desses pacientes, respeitando a importância da relação cão-tutor e buscando promover emoções positivas, mitigando as negativas neste ambiente e durante o tratamento do paciente canino. Esta abordagem, iniciada com a publicação de Animal Machines, de Ruth Harrison, em 1964, ganhou maior expressão nos últimos anos com o avanço do conhecimento cientifico na área de bem-estar animal, e, para os animais de companhia, em especial, como reflexo do aumento do número destes nos grandes centros, integrado como parte dos membros das famílias humanas. Assim, o bem-estar passa a ser o pilar do tratamento e não o complemento. Desta forma, o objetivo deste estudo foi identificar, por meio de revisão de literatura, os aspectos da fisiologia e do comportamento dos cães, bem como os resultados já publicados, em relação às características do ambiente e da condução do atendimento e internação destes nas clínicas e hospitais veterinários, que influenciam de forma positiva ou negativa seu bem-estar.

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“…Para além de ajustar o calendário do relógio, luz brilhante tem um outro efeito. Esta inibe diretamente a liberação de melatonina (SINGH;JADHAV, 2014;KAPPEN et al 2014).…”

Section: Ciclo Circadianounclassified

O Bem-Estar De Cães Na Prática Hospitalar

Aguiar¹,

Ribeiro²,

Balda³

et al. 2017

Enci Bio

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“…It results from abnormal neuronal discharge originating from the brain (Singh and Jadhav, 2014). Synaptic transmission is an important communication between presynaptic and postsynaptic neurons and depends on the formation, release, and endocytosis of the synaptic vesicle.…”

Section: Epilepsymentioning

confidence: 99%

Dynamin Functions and Ligands: Classical Mechanisms Behind

2016

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Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down's syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders.

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“…The most plausible hypothesis through which ELF-MF induced biological effects occur is the radical pair mechanism (RPM) (Timmel et al, 1998;Brocklehurst, 2002;Hore, 2012). Upon formation of a free radical, the unpaired electron within the outermost atomic orbital can be identified as existing in one of two spin states: ↑ or ↓ (Rodgers & Hore, 2009 (Singh & Jadhav, 2014). Collectively known as reactive oxygen species (ROS) they occur through the conversion of molecular oxygen into water and the subsequent release of electrons from the mitochondrial electron transport chain into the respiratory system (Singh & Jadhav, 2014).…”

Section: Radical Pair Mechanismmentioning

confidence: 99%

“…Melatonin plays a key regulatory role in many important physiological processes which occur with a daily or seasonal synchronisation, such as metabolism regulation, reproduction, sleep (reviewed in Singh & Jadhav, (2014)) and the modulation of hormones (reviewed in (Pandi-Perumal el al., 2006;Slominski et al, 2012)). Moreover, a reduced melatonin concentration has been reported post-magnetic field exposure (Welker et al, 1983), while the suppression of melatonin has been linked to various diseases, including cancer (reviewed in Hill et al, (2011)).…”

Section: Mechanism 1131 the Melatonin Hypothesismentioning

confidence: 99%

“…The presence of light is detected by non-rod and non-cone receptors in the retina. Once the light intensity declines below a threshold of ~10 lux (Henshaw & Reiter, 2005), a signal is sent via the retinohypothalmic tract to the suprachiasmatic nuclei (Okamura et al, 2002), which in turn prompts the regulation of melatonin production, primarily in the pineal gland through the parenchymatous cells (Singh & Jadhav, 2014).…”

Section: Mechanism 1131 the Melatonin Hypothesismentioning

confidence: 99%

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