Melatonin and Atopy: Role in Atopic Dermatitis and Asthma

Marseglia, Lucia; D’Angelo, Gabriella; Manti, Sara; Salpietro, Carmelo; Arrigo, Teresa; Barberi, Ignazio; Reíter, Russel J.; Gitto, Eloisa

doi:10.3390/ijms150813482

Cited by 70 publications

(73 citation statements)

References 85 publications

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“…As mast cells are highly sensitive to pathogen exposure, this could be an explanation for the divergent results. Other environmental influences like sleep cycles and different diet could as well influence mast cell quantities (, S3–S5 in Data S1). Although we performed our experiments with the exact same mouse strain as Zhou et al, the two manuscripts differ as we only used corresponding littermates as WT controls instead of unrelated C57BL/6 mice.…”

Section: Resultsmentioning

confidence: 99%

Normal mast cell numbers in the tissues of AhR‐deficient mice

Pilz

Feyerabend

Sonner

et al. 2015

Experimental Dermatology

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The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.

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Section: Resultsmentioning

confidence: 99%

Normal mast cell numbers in the tissues of AhR‐deficient mice

Pilz

Feyerabend

Sonner

et al. 2015

Experimental Dermatology

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“…Although thyroid autoimmunity has regularly been associated with atopy in children, the possible protective role of antioxidants, such as melatonin, has not yet been fully investigated, although its role has been documented in other atopic conditions, such as dermatitis and asthma [17, 18]. …”

Section: Introductionmentioning

confidence: 99%

“…Experimental data [17] suggested that melatonin inhibits development of atopic eczema, a condition accompanied by infiltration and activation of mast cells with release vasoactive and proinflammatory mediators, and reduces serum total IgE and IL-4.…”

Section: Introductionmentioning

confidence: 99%

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Atopy and autoimmune thyroid diseases: melatonin can be useful?

et al. 2016

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Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis of literature data shows a strong positive association between a history of Th2-mediated allergic disorders and Th1-mediated autoimmune disorders.Autoimmune thyroid diseases are the most common of all autoimmune pathological conditions.Currently, the mechanisms explaining an association among atopy, autoimmunity, and thyroid diseases are not fully understood.There are data in literature pointing to the relationship between melatonin and thyroid activity. Several studies have suggested a paracrine role for this molecule in the regulation of thyroid activity, documenting that administration, as an antioxidant, in thyroid tissues under conditions of increased oxidative stress, could be helpful to reduce the oxidative processes involved in autoimmune thyroid diseases.Although thyroid autoimmunity has been regularly associated with atopic conditions in children, the possible protective role of melatonin has not yet been investigated.This review summarizes what is known regarding the connection between atopy and autoimmune thyroid diseases, and analyses the probable beneficial action of melatonin.

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“…Although extensive experimental and human studies have been performed to identify the immunological cause of atopy, its etiology remains obscure [2,3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Association between Allergies and Hypercholesterolemia: A Systematic Review

Manti

Cuppari²,

Marseglia³

et al. 2017

Int Arch Allergy Immunol

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Background: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. Methods: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations. Information on the study design, sample, intervention, comparators, outcome, time frame, and risk of bias were abstracted for each article. Results: Of 601 reviewed reports, 18 were included in this systematic review. Fifteen studies assessed the relationship between AP and serum cholesterol levels. Due to the lack both of observational and cross-sectional studies from the literature search at this time (only 8 studies also analyzed confounding factors) there is a high possibility of confounding variables (familial and genetic predisposition, age, gender, BMI, comorbidity, and medication status) that could not be ruled out. Conclusion: Existing studies are heterogeneous, making it difficult to draw broad conclusions. Future studies and more detailed analyses, considering confounding variables and including a larger and homogeneous population, are needed to strengthen the argument for a link between lipid metabolism and atopy.

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Melatonin and Atopy: Role in Atopic Dermatitis and Asthma

Cited by 70 publications

References 85 publications

Normal mast cell numbers in the tissues of AhR‐deficient mice

Normal mast cell numbers in the tissues of AhR‐deficient mice

Atopy and autoimmune thyroid diseases: melatonin can be useful?

Association between Allergies and Hypercholesterolemia: A Systematic Review

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