Melatonin and 6-Hydroxymelatonin Sulfate Excretion Is Inversely Correlated with Gonadal Development in Children

Commentz, J C; Uhlig, Holger; Henke, Alexander; Hellwege, H. H.; Willig, R. P.

doi:10.1159/000185442

Cited by 22 publications

(14 citation statements)

References 20 publications

(24 reference statements)

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“…A strong inverse correlation has been documented between the nocturnal concentration of melatonin and age, Tanner stage and the LH concentration [39, 40]. Nevertheless, in our cases with morning samples, no correlation was found in the overall group (with two evaluations for every subject) between melatonin and LH, in either sex.…”

Section: Discussioncontrasting

confidence: 50%

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Molina-Carballo

Fernández-Tardáguila²,

Uberos‐Fernández³

et al. 2007

Horm Res Paediatr

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Background/Aims: Pubertal changes are a consequence of the activation of the hypothalamic-pituitary-gonadal axis due to an increase in the frequency and magnitude of pulses of gonadotropin-releasing hormone (GnRH), which may depend on the intrinsic properties of the neurons of the hypothalamic arcuatus nucleus, or on the influence of neurotransmitters and/or neuromodulators. We evaluated the serum concentrations of melatonin and leptin in healthy prepubertal and adolescent subjects of both sexes, to define their participation at the initial stages and during the progression of pubertal development. Methods: 80 pediatric subjects (47 females and 33 males), aged 6–18 years, were divided into 2 groups, prepubertal (n = 25) and adolescent (n = 55), according to the absence or presence, respectively, of physical signs of pubertal development. The subjects were assessed on two occasions: at the time of their inclusion in the study, and 12–18 months later when the subject had advanced one pubertal stage according to the Tanner classification. Blood was obtained in fasting for clinical purposes and for the hormonal study. Melatonin and leptin were measured by radioimmunoanalysis. Results: As described previously, melatonin decreases at the onset of puberty and during pubertal development. Both the absolute melatonin value and the decrease between evaluations tended to be greater in females; the variations were correlated with neither an increase in body weight nor with the degree of pubertal development. The concentration of leptin increased in both sexes with the progression of puberty, this value being 40% greater in women, and correlated with the indicators of an increase in body volume and fat accumulation. Although its concentration remained stable between evaluations for both sexes, among the males the association between leptin and pubertal development took place at the start of the process, while for the females we observed a significant overall association between pubertal stage and leptin concentration, this association being stronger at more advanced Tanner stages. Neither at the onset of puberty nor during its course did we observe any significant relation between melatonin concentration and any of the Tanner stages, whether for males or for females. Neither was there any correlation between the absolute values or rates of modification of melatonin and leptin. Conclusion: According to the evolutionary dynamics of their respective concentrations, both initially and during pubertal progress, melatonin and leptin do not interact in the initiation or progression of human pubertal development, and do not seem to play a key role in this process.

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Section: Discussioncontrasting

confidence: 50%

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Molina-Carballo

Fernández-Tardáguila²,

Uberos‐Fernández³

et al. 2007

Horm Res Paediatr

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“…[5] By 6-8 years, the levels are similar to adult levels; however, MLT expression decreases once again between 8-13 years of age, and increases again between 13-15 years of age. MLT receptor expression has been verifi ed in many tissues and organs, and studies [2,6] have demonstrated the various biological effects of MLT: day-night rhythm regulation, sexual maturation, reproduction, immune reaction, tumor and aging, modulation of arterial blood pressure and heart rate, free radical clearance and antioxidation, as well as inhibition of platelet aggregation and lipid peroxidation.…”

Section: Original Articlementioning

confidence: 85%

“…[5] In addition, lymphocyte phenotype and function are different between adults and children. In this study MLT enhanced the proliferation of neonatal mononuclear cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of melatonin on proliferation of neonatal cord blood mononuclear cells

Wei

Wang

2009

World J Pediatr

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“…6-OHMS is the major enzymatic metabolite of melatonin [48] and has frequently been shown to correlate with serum melatonin concentrations [34,35]. The well-documented rapid fall of melatonin levels in serum from childhood to puberty [47] is mainly correlated with an increase in body mass during that period with a corresponding increase in serum volume rather than a decreasing melatonin production, analyzed here with 24-hour urine samples.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Associations between Endogenous Melatonin Production and Reported Sleep Duration from Childhood to Early Adulthood

et al. 2010

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Background/Aims: The study objective was to assess longitudinal associations between melatonin secretion and reported sleep duration from childhood to early adulthood. Methods: In the frame of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study, 24-hour melatonin secretion and average daily sleep duration were determined once during childhood (4–< 11 years), adolescence (11–<16 years) and early adulthood (16–19 years) in 52 participants (23 males/29 females) aged 4–19 years. The associations between (1) melatonin secretion and sleep duration in childhood (cross-sectional); (2) melatonin secretion in childhood and sleep duration in early adulthood (prospective), and (3) changes in melatonin secretion and concurrent changes in sleep duration from childhood to early adulthood (concurrent) were analyzed. Results: Melatonin secretion was associated with sleep duration in childhood (cross-sectional, 3.5 min/day/10 µg 6-hydroxymelatonin sulfate (6-OHMS)/day, p = 0.009) and tended to predict sleep duration in early adulthood (prospective, 9.8 min/day/10 µg 6-OHMS/day, p = 0.09). An individual increase in melatonin secretion between childhood and early adulthood was associated with a concurrent increase in sleep duration (concurrent, 6.9 min/day/10 µg 6-OHMS/day, p = 0.046). Conclusion: Our observational data suggest that pineal production of melatonin in childhood is correlated with alterations in sleep duration until early adulthood. Nevertheless, this observational evidence needs to be verified in clinical studies.

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Melatonin and 6-Hydroxymelatonin Sulfate Excretion Is Inversely Correlated with Gonadal Development in Children

Cited by 22 publications

References 20 publications

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Effect of melatonin on proliferation of neonatal cord blood mononuclear cells

Longitudinal Associations between Endogenous Melatonin Production and Reported Sleep Duration from Childhood to Early Adulthood

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