Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high‐fat diet‐induced obesity in male Wistar rats

Oladele, Comfort Abisola; Akintayo, Christopher O.; Badejogbin, Olabimpe C.; Oniyide, Adesola A.; Omoaghe, Adams O.; Agunbiade, Toluwani B.; Olaniyi, Kehinde S.

doi:10.1111/and.14242

Cited by 12 publications

(12 citation statements)

References 82 publications

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“…HDF is also associated with dysfunction of the endocrine glands. In this regard, melatonin can alleviate spermatogenesis and steroidogenesis disorders caused by HDF‐related obesity by affecting hypothalamic–pituitary‐gonadal axis function (Oladele et al, 2022).…”

Section: Melatonin and Signalling Pathwaysmentioning

confidence: 99%

Overview of biological effects of melatonin on testis: A review

et al. 2022

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Infertility is a major global health issue and male factors account for half of all infertility cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which may occur because of chemotherapy, radiotherapy or genetic defects. In numerous animal species, the evidence suggests the pineal gland and melatonin secretion in their reproductive activities are involved. Recently, considerable attention has pointed to the usage of melatonin in the treatment of diseases. Melatonin is associated with the regulation of circadian and seasonal rhythmic functions, immune system functions, retinal physiology, spermatogenesis and inhibition of tumour growth in different species. Several studies demonstrated that melatonin acts as an anti‐apoptotic, anti‐inflammatory, anticancer and antioxidant agent. Melatonin can also protect testicles and spermatogonia against oxidative damage, chemotherapy drugs, environmental radiation, toxic substances, hyperthermia, ischemia/reperfusion, diabetes‐induced testicular damage, metal‐induced testicular toxicity, improve sperm quality and it affects the testosterone secretion pathway by affecting Leydig cells. Therefore, the objective of this study is to investigate the biological effects of melatonin as a natural antioxidant on testicles and their disorders.

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Section: Melatonin and Signalling Pathwaysmentioning

confidence: 99%

Overview of biological effects of melatonin on testis: A review

et al. 2022

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“…This same pattern, however, was not observed in participants with inadequate consumption. This suggests a possible improvement in subclinical glucose tolerance, suppressed by the inflammatory status caused by the chronic misalignment inherent to chronic night work ( 62 , 63 ).…”

Section: Discussionmentioning

confidence: 99%

12-week melatonin administration had no effect on diabetes risk markers and fat intake in overweight women night workers

de Sousa,

Nogueira,

Cipolla-Neto

et al. 2024

Front. Nutr.

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IntroductionInteractions between circadian clocks and key mediators of chronic low-grade inflammation associated with fat consumption may be important in maintaining metabolic homeostasis and may pose a risk for the development of obesity-associated comorbidities, especially type 2 diabetes (T2DM).ObjectiveThe aims of the present study were to evaluate the effects of melatonin administration on diabetes risk markers according to dietary lipid profile (pro-inflammatory versus anti-inflammatory) in excessive weight night workers, and to determine the effect of administration on fat consumption profile.MethodsA randomized, controlled, double-blind, crossover clinical trial involving 27 nursing professionals working permanent night shifts under a 12×36-hour system. The melatonin group (12 weeks) used synthetic melatonin (3 mg) only on days off and between shifts, while the placebo group (12 weeks) was instructed to take a placebo, also on days off and between shifts. For inflammatory characteristics, participants were divided into pro-inflammatory (saturated fats, trans fats and cholesterol) and anti-inflammatory (monounsaturated, polyunsaturated fats and EPA + DHA) groups according to fatty acid determinations. At baseline and at the end of each phase, blood glucose, insulin, glycosylated hemoglobin plasma concentrations were collected, and HOMA-IR was calculated.ConclusionMelatonin administration for 12 weeks had no effect on T2DM risk markers according to dietary lipid profile (pro-inflammatory or anti-inflammatory potential) in excessive weight night workers. Among the limitations of the study include the fact that the low dose may have influenced the results expected in the hypothesis, and individual adaptations to night work were not evaluated. The insights discussed are important for future research investigating the influence of melatonin and fats considered anti- or pro-inflammatory on glucose and insulin homeostasis related to night work.

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“…Oxidative stress is highly correlated with a wide range of metabolic disease states, including metabolic disorders induced by a HFD. 38,39 Oxidative stress is a process in which free radicals, which are inadequately neutralized by antioxidants, cause cumulative damage, and this damage is aggravated by the reduced activity of antioxidative enzymes, such as SOD. 40 Numerous studies have reported that there are many sources of oxidative stress in animals fed a HFD.…”

Section: Discussionmentioning

confidence: 99%

The time-dependent adverse effects of a high-fat diet on sperm parameters

Qi¹,

Guan²,

Zhang³

et al. 2023

Adv Clin Exp Med

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Background. Studies indicate a relationship between a high-fat diet (HFD) and sperm quality. However, the time-dependent adverse effects of a HFD on sperm parameters and the underlying mechanisms remain unclear.Objectives. The present study was designed to determine the effects of a HFD on sperm quality at various time points in order to assess whether a HFD causes cumulative damage to sperm. Materials and methods.Male C57BL/6 mice were fed a normal diet (the ND group) or a HFD (the HFD group) for 16, 30 or 42 weeks (n = 6 for each group). Body weight, lipid profile, sperm parameters, testicular morphology, and testicular oxidative stress levels were evaluated alongside the proliferation, DNA damage and rate of germ cell apoptosis.Results. Sperm quality was reduced in HFD-fed animals in a time-dependent manner, which was demonstrated by a decline in sperm density, motility and progressive motility. Further analysis showed a progressive deterioration of the testicular histoarchitecture of HFD-fed mice, which was accompanied by a decrease in DEAD-box helicase 4 (DDX4) expression and superoxide dismutase (SOD) levels, increased malondialdehyde (MDA) levels and gamma-H2A histone family member X (γ-H2AX) expression, and increased apoptosis of germ cells.Conclusions. These findings demonstrate that a HFD exerted adverse effects on sperm quality, and the deteriorating effect was progressive with long-term feeding. The inhibited proliferation and apoptosis of germ cells, and the increased oxidative stress levels and DNA damage may be the underlying mechanisms.

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Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high‐fat diet‐induced obesity in male Wistar rats

Cited by 12 publications

References 82 publications

Overview of biological effects of melatonin on testis: A review

Overview of biological effects of melatonin on testis: A review

12-week melatonin administration had no effect on diabetes risk markers and fat intake in overweight women night workers

The time-dependent adverse effects of a high-fat diet on sperm parameters

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