Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy

Liu, Jie; Ren, Hong; Zhang, Yujie; Sha, Lu-Lin; Chen, Wei; Ren, Xiaofei

doi:10.1007/s11596-022-2530-7

Cited by 4 publications

(1 citation statement)

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“…It also acts primarily as an antioxidant and anti-inflammatory agent. [ 69 ]. Tahan, Akin [ 70 ] found that bile-duct ligation caused levels of collagen, MDA, luminal, and lucigenin to rise while GSH levels fell; however, melatonin had the opposite effect.…”

Section: Introductionmentioning

confidence: 99%

Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management

El-Fattah

Zakaria

2022

J Transl Med

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Liver fibrosis is a liver disease in which there is an excessive buildup of extracellular matrix proteins, including collagen. By regulating cytokine production and the inflammatory response, heat shock proteins (HSPs) contribute significantly to a wider spectrum of fibrotic illnesses, such as lung, liver, and idiopathic pulmonary fibrosis by aiding in the folding and assembly of freshly synthesized proteins, HSPs serve as chaperones. HSP70 is one of the key HSPs in avoiding protein aggregation which induces its action by sending unfolded and/or misfolded proteins to the ubiquitin–proteasome degradation pathway and antagonizing influence on epithelial-mesenchymal transition. HSP47, on the other hand, is crucial for boosting collagen synthesis, and deposition, and fostering the emergence of fibrotic disorders. The current review aims to provide light on how HSP70 and HSP47 affect hepatic fibrogenesis. Additionally, our review looks into new therapeutic approaches that target HSP70 and HSP47 and could potentially be used as drug candidates to treat liver fibrosis, especially in cases of comorbidities.

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Section: Introductionmentioning

confidence: 99%