Mélanome sur site d’exérèse d’un nævus dysplasique au cours d’un traitement par étanercept

Cutaneous melanoma in patients treated with tumour necrosis factor inhibitors: a retrospective series of 15 patients

“…Fifteen cases were included in the analysis (Tables and ). One case has been previously reported . Seven patients were of phototype III and the eight other patients were of phototype II.…”

“…In this retrospective study conducted on a defined geographic area, we identified 15 cases of patients with melanoma who received anti‐TNF therapy. To our knowledge, this study represents the largest case series because only sporadic case reports have been published . Our main objective was to point if history of melanoma in patients exposed to anti‐TNF treatment would present with a particular pattern at diagnosis or during follow‐up.…”

“…Although both cases were considered possibly related to anti‐TNF treatment, a causal relationship could not be confirmed. To date, most cases of aggressive melanoma have been previously reported in patients with anti‐TNF . In 2012, 11 176 new cases of cutaneous melanoma were estimated in France.…”

“…However, a recent study cohort has demonstrated an increased relative risk of invasive melanoma in rheumatoid arthritis patients selected for TNF inhibitors . Finally, several case reports suggested that anti‐TNF might alter the natural course of melanoma towards a more aggressive profile . However, publication bias is a concern as cases with remarkable courses have more likely been reported.…”

Melanoma Cutâneo Primário: Complicação De Tratamento Com Infliximab?

“…Bongartz 1 em 2006, efetuou uma meta-análise, onde incluiu 9 estudos randomizados e controlados, envolvendo doentes com artrite reumatoide a efetuar terapia biológica anti-TNFα há pelo menos 12 semanas, tendo verificado existir um aumento estatisticamente significativo das infeções graves e dos tumores malignos, em particular de linfomas e de tumores cutâneos não melanomas [2][3][4] . O melanoma maligno tem sido menos vezes associado à terapia anti-TNFα, no entanto a revisão da literatura sugere uma relação possível quer com o aparecimento de melanoma maligno primário, com a reativação de melanomas latentes [5][6][7][8][9][10][11][12] , e mesmo com o aparecimento de nevos melanociticos eruptivos [13][14] .…”