Melanoma resembling spindle and epithelioid cell nevus

Mr, Okun

doi:10.1001/archderm.115.12.1416

Cited by 44 publications

(30 citation statements)

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“…Piepkorn cites as worrisome findings high-grade nuclear atypia, high mitotic rate with deep dermal mitoses or atypical mitoses, no or only focal maturation at the base, deep penetration into lower dermis or subcutis, ulceration, and large lesional size. 20 Other authors have cited similar criteria, as well as other criteria, for the diagnosis of Spitz-like melanoma, such as marked pagetoid spread, 26 singlecell epidermal invasion below parakeratosis, 27 asymmetry, 5 destruction of collagen, 3 substantial and/or deep melanization, 21 and variability of cellular features between adjacent cell groups. 4 Reed proposed that confluent or expansile, nodular aggregates of atypical Spitz-like cells in the dermis represent a vertical growth phase or possess a competence for metastasis and are regarded best as minimal deviation melanoma, Spitz-like type.…”

Section: Discussionmentioning

confidence: 92%

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Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Fullen

Sondak

et al. 2003

Cancer

146

122

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A new device—the rotational particle separator (RPS)—is compared to the cyclone for the removal of ultrafine particles, such as cryogenically condensed contaminant droplets from natural gas. The comparison focusses on identifying for each configuration the smallest size of particle which has a 50% chance of being removed from the gas stream. Whereas a cyclone can only separate 1 μm droplets at very low‐throughputs on the order of 1 MMscfd, at the same energy consumption and device volume, the rotational particle separator removes droplets of that size at throughputs of 300 MMscfd. The advantage of the rotational particle separator, therefore, lies in its compact separation potential for full‐scale industrial gas well throughputs. © 2006 American Institute of Chemical Engineers AIChE J, 2007

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Section: Discussionmentioning

confidence: 92%

“…6,7,20 The reports of widely metastasizing disease from lesions not histologically discernable from banal Spitz nevi [21][22][23] support this concept of a phenotypic continuum and underscore the point that the accurate diagnosis of melanoma with Spitzoid features can be problematic, even for the most experienced dermatopathologist.…”

Section: Discussionmentioning

confidence: 97%

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Fullen

Sondak

et al. 2003

Cancer

146

122

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“…20,27,33,56 The term probably best describes a rare group of tumors often developing in young individuals who are only diagnosed as melanoma in retrospect, that is, after the development of metastases and an aggressive course. Given the profound difficulty of distinguishing some Spitz tumors from melanoma, the author discourages the use of term Spitzoid melanoma since it may result in the indiscriminate labeling of a heterogeneous group of lesions including benign Spitz tumors, lesions that are biologically indeterminant, conventional melanomas, and also the rare controversial group of tumors mentioned above: 'metastasizing Spitz tumor'.…”

Section: Spitzoid Melanomamentioning

confidence: 99%

The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma' and risk assessment

2006

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Although much remains to be learned about Spitzoid lesions, there is increasing evidence that these tumors may be a type of melanocytic neoplasm distinct from conventional melanocytic nevi and malignant melanoma. In the current communication, the author has attempted to describe accurately the state-of-the-art surrounding these lesions, their nomenclature, and assessment of risk. Acknowledging the peculiar nature of Spitzoid lesions, the author prefers the term Spitz tumor rather than 'Spitz nevus' (except perhaps for the most typical lesions) and argues against using the term 'Spitzoid melanoma' until more information is available to justify such a term. The author also believes that patients are best served by the comprehensive evaluation of Spitzoid lesions and their classification into three categories: (1) Spitz tumor without significant abnormality, (2) Spitz tumor with one or more atypical features (atypical Spitz tumor), including those judged to have indeterminate biological potential, and (3) malignant melanoma, rather than the two categories of 'Spitz nevus' and melanoma. Only rigorous characterization of sufficient numbers of Spitzoid lesions and long-term follow-up of patients will provide truly objective information for the formulation of optimal guidelines for the management of patients with these lesions.

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“…Due to the rarity of melanomas in children and young adults and the increased incidence of Spitz nevus for these age groups, the diagnosis of malignant melanoma should always be rendered with extreme caution [2]. Diagnostic criteria for the differentiation of Spitz nevi from malignant melanoma have been well-delineated [3,4]; however, this distinction is not always reliably made, and Spitz nevus resembling malignant melanoma as well as the converse may occasionally be encountered [5]. In addition, the distinction between common and uncommon melanocytic lesions and borderline melanoma may not always be rendered with certainty [6,7].…”

Section: Case Reportmentioning

confidence: 99%

Verrucous pseudonevoid melanoma

Suster

Ronnen

Bubis

1987

Journal of Surgical Oncology

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A case of an unusual variant of malignant melanoma resembling a papillomatous dermal nevus is presented here. The lesion was initially diagnosed as a Spitz nevus, and recurred locally five months after excision. The features which distinguish this lesion from the more common types of benign dermal nevi include the architectural atypia of the melanocytes, with a tendency for continuous proliferation of single cells along the dermoepidermal junction, as well as the presence of cytologic atypia with large hyperchromatic nuclei and mitoses. Despite its seemingly innocent appearance, distinction of this low-grade variant of melanoma from its benign counterparts is of importance in order to avert the possibility of recurrence and potential metastases.

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Melanoma resembling spindle and epithelioid cell nevus

Cited by 44 publications

References 0 publications

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma' and risk assessment

Verrucous pseudonevoid melanoma

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