Melanogenesis and Skin Carcinoma

Everett, Mark Allen

doi:10.1001/archderm.1960.01580060062007

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…As a general rule, it is elear that suseeptibility to skin cancer varies inversely as the proportion of melanin in the skin, and many workers have confirmed this view (Everett, Bell and Hagans, 1960 ;Belisario, 1962 ;Carmiehael, 1962 ;Silverstone et al, 1963 ;Freeman and Knox, 1967 ;Gellin, Kopf and Garfinkel, 1969 ;MeGovern and Lane Brown, 1969). There are, however, exeeptions to the general rule that require consideration in determining individual susceptibility, in particular the evenness of spread of melanin and the effect of long-term solar exposure on melanin produetion.…”

Section: (1) the Stratum Gorneummentioning

confidence: 96%

“…(2) Melanin Most workers now agree that melanin is the most important protector from UVL (Everett, Bell and Hagans, 1960) and it is claimed that in tropical countries albino members of dark-skinned races usually die from squamous cell carcinoma (McGovern and Lane Brown, 1969). In 1958 it was suggested by the author and V. J. MeGovern (Mackie and McGovern, 1958) that in fair-skinned subjects the limited protective action of melanin occurred in the basal layer, it being believed that melanin only passed to the more superficial layers in dark-skinne(i subjects.…”

Section: (1) the Stratum Gorneummentioning

confidence: 99%

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Susceptibility to Skin Cancer

Mackie¹

1971

Australas J Dermatol

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Blum's experiments with albino mice demonstrate a wide variation in the resistance cf individual subjects to the carcinogenic effect of ultraviolet light. From clinical experience humans are thought to show the same wide variation in resistance and this paper is a discussion of some of the possible reasons for this variation.It is now well established that ultraviolet lijiht (UVL) is a major cause of skill cancer,! and there is ample clinical and experimental evidence to substantiate this belief (Blum

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Section: (1) the Stratum Gorneummentioning

confidence: 96%

Section: (1) the Stratum Gorneummentioning

confidence: 99%

Susceptibility to Skin Cancer

Mackie¹

1971

Australas J Dermatol

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“…By this technique, Everett et al demonstrated a decrease in melanin as well as a significantly low tanning response to ultraviolet light in the skin of patients with carcinoma as compared with subjects without cutaneous carcinoma. 12 McGovern, in a study of melanoma with regard to the influence of sunlight and complexion, also concluded that malignant transformation of a mole is more common in the fair-skinned person who does not tan well upon exposure to light, but who freckles readily. 2 In pathological examination of 229 melanoma specimens McGovern and Mackie found that where the melanoma arose in nevi that appeared first in adult life, especially in older females, and were located about the head and neck, the tumor was frequently associated with collagen degeneration of the dermis.…”

mentioning

confidence: 99%

The Relation of Race and Complexion to the Incidence of Moles and Melanomas

Pack

Davis

Oppenheim

1963

Annals of the New York Academy of Sciences

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Some environmental and bodily characteristics of melanoma patients. A case‐control study

Klepp

Magnus

1979

Intl Journal of Cancer

124

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A case-control study including 78 patients with malignant melanoma of the skin and 131 controls with the diagnoses of malignant lymphoma, testicular cancer or bone and soft-tissue sarcoma, was performed at the Norwegian Radium Hospital 1974-1975. The questionnaire contained questions for evaluating the comparability between cases and controls, and questions bearing on the relation between sun exposure and malignant melanoma. No essential difference between cases and controls was found as regards hair and eye colour, time spent outdoors during leisure, and degree of solar exposure. The melanoma patients liked sunbathing less than controls, worked more outdoors, more often went to Southern Europe for sunbathing and more often used sun lotions. These differences, however, were not clearly statistically significant. Highly significant differences were demonstrated as regards the tolerance of sun exposure and propensity to freckling. The melanoma patients tolerated sun exposure less well and freckled more easily than the controls. Although attempts were made to eliminate bias, there are still limitations and loop-holes in the study, and the relative risks demonstrated are not large enough to be of great immediate practical or scientific value. It seems justified, however, to advise persons with a low sun exposure tolerance to be cautious in following the sun-tan-demanding fashions. The study may also provide certain clues for the planning of future epidemiological and clinical studies regarding the etiology of malignant melanoma.

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Melanogenesis and Skin Carcinoma

Cited by 6 publications

References 2 publications

Susceptibility to Skin Cancer

Susceptibility to Skin Cancer

The Relation of Race and Complexion to the Incidence of Moles and Melanomas

Some environmental and bodily characteristics of melanoma patients. A case‐control study

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