Melanocytic Proliferations Associated With Lichen Sclerosus

Carlson, John A.; Mu, Xiao C.; Słomiński, Andrzej; Weismann, K; Crowson, A. Neil; Malfetano, John H.; Prieto, Víctor G.; Mihm, Martín C.

doi:10.1001/archderm.138.1.77

Cited by 128 publications

(126 citation statements)

References 93 publications

(103 reference statements)

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“…Similar cases of eruptive melanocytic nevi were described following Stevens-Johnson syndrome episodes, erythema multiforme and associated with lichen sclerosus and atrophicus [9][10][11][12] . The proposed pathogenesis is similar to that related to EB nevus.…”

Section: Discussionsupporting

confidence: 55%

“…The proposed pathogenesis is similar to that related to EB nevus. 3,[9][10][11][12] There is only one report describing a child with bullous pemphigoid located on the a vulva, where recurrent blisters developed, an atypical melanocytic nevus with clinical and dermoscopic characteristics of melanoma. 13 This was the first case where a melanocytic nevus developed on the site of bullous lesions, in bullous autoimmune and subepidermal disease in childhood.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nevo da epidermólise bolhosa: caso clínico e revisão da literatura

Cotrim

Simone

Lima

et al. 2011

An. Bras. Dermatol.

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Acquired melanocytic lesions resembling malignant melanoma have been described in all major categories of Epidermolysis bullosa and referred to as "Epidermolysis bullosa nevi''. They easily induce to diagnostic error, although no malignant transformation has been reported. We report the development of a large acquired melanocytic nevus at a site of recurrent blisters in a 5-year-old child with Epidermolysis bullosa simplex. The global dermoscopic pattern was suggestive of benignity, and the histopathological findings were compatible with a compound melanocytic nevus. This is the first published case of Epidermolysis bullosa nevi in Brazilian literature. Despite their benign behavior, we emphasize the importance of regular clinical and dermoscopic monitoring, since a malignant course still cannot be totally excluded. Keywords: Biopsy; Dermoscopy; Epidermolysis bullosa; Melanoma; Nevus, pigmented Resumo: Lesões melanocíticas adquiridas assemelhando-se à melanoma têm sido descritas nos principais grupos da Epidermólise bolhosa, e referidas como "Nevos da Epidermólise bolhosa''. Induzem facilmente ao erro diagnóstico, apesar de nenhuma transformação maligna ter sido descrita. Relatamos o desenvolvimento de um nevo melanocítico adquirido grande no local de bolhas recorrentes em uma criança de 5 anos portadora de Epidermólise bolhosa simples. O padrão dermatoscópico global foi sugestivo de benignidade, e os achados histopatológicos foram compatíveis com um nevo melanocítico composto. Este é o primeiro caso de um Nevo da Epidermólise bolhosa publicado na literatura brasileira.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Nevo da epidermólise bolhosa: caso clínico e revisão da literatura

Cotrim

Simone

Lima

et al. 2011

An. Bras. Dermatol.

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“…32 It is also important to bear in mind that melanocytic proliferations associated with LS have been documented. 35,36 It is not clear whether or not LS developing in association with vulval melanoma is an immune response to the melanoma.…”

Section: Associated Malignancymentioning

confidence: 99%

Paediatric vulval lichen sclerosus

Smith

Fischer

2009

Aust J Dermatology

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Lichen sclerosus (LS) in children is uncommon; however, it is an important differential diagnosis in any pre-pubertal child presenting with chronic vulval symptoms. The long-term prognosis is unknown; however, recent data suggests that the assumption that the condition will resolve at puberty may be incorrect. Children with LS require long-term management with topical corticosteroids, which remains the treatment of choice, as well as long-term follow up. We review the current literature on paediatric vulval LS.

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“…Collision between lichen sclerosus et atrophicus and melanocytic nevus represents an analogous phenomenon. 11,12 These collision phenomena have led to diagnostic difficulties for the clinicians and histopathologists because the expected clinical and histopathologic findings of the melanocytic lesions are significantly altered. Similar to the EB nevus, the persistent melanocytic pattern is observed histopathologically in cases of collision with lichen sclerosus.…”

Section: Commentmentioning

confidence: 99%