2020
DOI: 10.3390/ijms21197036
View full text | Cite
|
Sign up to set email alerts
|

Abstract: The melanocortin receptor 4 (MC4R) signaling system consists of MC4R, MC4R ligands [melanocyte-stimulating hormone (MSH), adrenocorticotropin (ACTH), agouti-related protein (AgRP)], and melanocortin-2 receptor accessory protein 2 (MRAP2), and it has been proposed to play important roles in feeding and growth in vertebrates. However, the expression and functionality of this system have not been fully characterized in teleosts. Here, we cloned tilapia MC4R, MRAP2b, AgRPs (AgRP, AgRP2), and POMCs (POMCa1, POMCb) … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
3
0

Year Published

2021
2021
2022
2022

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 55 publications
(137 reference statements)
1
3
0
Order By: Relevance
“…Most of these associated features might be regulated by α-MSH [19,45], suggesting their critical functions in controlling metabolism observed in our α-MSH mutant zebrafish (Figure 7B). In line with previous reports, most metabolic defects observed in fish [62], mammalian models [4,63,64], and humans [65][66][67] have been attributed to the impairment of functional MC4R signaling in various pomc mutants.…”
Section: Discussionsupporting
confidence: 90%
“…Most of these associated features might be regulated by α-MSH [19,45], suggesting their critical functions in controlling metabolism observed in our α-MSH mutant zebrafish (Figure 7B). In line with previous reports, most metabolic defects observed in fish [62], mammalian models [4,63,64], and humans [65][66][67] have been attributed to the impairment of functional MC4R signaling in various pomc mutants.…”
Section: Discussionsupporting
confidence: 90%
“…As described in our previous studies [ 48 , 50 ], CHO cells transfected with cADRA2A expression plasmid were cultured on a 24-well plate at 37 °C and then treated by NE (10 μM) for 10 min. Then, the cells were lysed and used for Western blot detection of β-actin, phosphorylated CREB (pCREB) (43 kDa) and (or) ERK1/2 (pERK1/2) (44/42 kDa).…”
Section: Methodsmentioning
confidence: 99%
“…As a paralogue of MRAP, MRAP2 shares a conserved functional domain and similar structural features with MRAP. However, unlike MRAP, which mainly regulates MC2R in the adrenal gland, MRAP2 shows more preference for the other four MCRs [ 16 , 17 , 18 , 19 , 20 ], as well as several non-melanocortin receptors, such as orexin receptor and ghrelin receptor [ 21 , 22 , 23 , 24 , 25 ]. MRAP2 is involved in energy balance and metabolism by regulating MC4R activity in many organisms [ 18 , 20 , 26 , 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, unlike MRAP, which mainly regulates MC2R in the adrenal gland, MRAP2 shows more preference for the other four MCRs [ 16 , 17 , 18 , 19 , 20 ], as well as several non-melanocortin receptors, such as orexin receptor and ghrelin receptor [ 21 , 22 , 23 , 24 , 25 ]. MRAP2 is involved in energy balance and metabolism by regulating MC4R activity in many organisms [ 18 , 20 , 26 , 27 ]. MRAP2 -deficient mice develop severe obesity, which is presumably resulting from a significant decrease in MC4R sensitivity to α-MSH in the absence of MRAP2 protein [ 28 ].…”
Section: Introductionmentioning
confidence: 99%