Melancholia

Parker, Gordon; Paterson, Amelia

doi:10.1097/yco.0000000000000024

Cited by 17 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, our definition of the AD symptom group was consistent with research that suggested mood reactivity was a poor indicator of AD (6, 7, 17, 20, 21);reversed-vegetative symptoms (and leaden paralysis) could validly be used to identify the AD subtype (28, 30), and a body of research indicating rejection sensitivity should be considered the core feature of AD (6, 17, 22, 23). However, it is quite important to note that the results of the current study do not reflect the findings of depressed individuals who meet the DSM-IV criteria for AD.…”

Section: Discussionsupporting

confidence: 72%

“…Indeed, there is a body of research arguing against mood reactivity as a criterion for AD (6, 7, 17, 20, 21). Specifically, researchers have argued that mood reactivity does not correlate with the other symptoms of AD, is indicative of lower levels of depression, and is a poor indicator of AD (6, 20, 21).…”

mentioning

confidence: 99%

“…Specifically, researchers have argued that mood reactivity does not correlate with the other symptoms of AD, is indicative of lower levels of depression, and is a poor indicator of AD (6, 20, 21). Thase takes issue with the DSM-IV criteria for AD.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Depressed Older Patients With the Atypical Features of Interpersonal Rejection Sensitivity and Reversed-Vegetative Symptoms are Similar to Younger Atypical Patients

Sachs‐Ericsson

Selby

Corsentino

et al. 2012

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

Objectives The atypical depression (AD) subtype has rarely been examined in older patients. However, younger AD patients have been characterized as having more severe and chronic symptoms of depression compared with non-AD patients. Design Secondary data analysis using ANOVAs and Growth Curve Modeling. Setting Clinical Research Center for the Study of Depression in Later Life. Participants Depressed older patients (N=248) followed over 2 years. Method In a longitudinal study, we examined depression severity and chronicity in patients with major depression with some features of atypical depression, specifically rejection sensitivity and reversed-vegetative symptoms (e.g., hyperphagia, hypersomnia), or leaden paralysis, and compared them to non-AD patients. The Diagnostic Interview Schedule (DIS) was used to assess depressive symptoms and history. Depression severity and chronicity were assessed every three months using the Montgomery Asberg Depression Rating Scale. Results The AD symptom group reported more DIS depressive symptoms, more thoughts about wanting to die, earlier age of onset, poorer social support and double the number of lifetime episodes than non-AD patients. Growth curve analyses revealed that, compared with non-AD patients, the AD symptom group had more residual symptoms of depression during the first year of follow-up, but not during the second year. Conclusion Characteristics of older patients with features of AD are similar to younger patients. Assessment of atypical symptoms, in particular rejection sensitivity and reversed-vegetative symptoms is essential, and should be considered in treatment plans.

show abstract

Section: Discussionsupporting

confidence: 72%

mentioning

confidence: 99%

See 1 more Smart Citation

Depressed Older Patients With the Atypical Features of Interpersonal Rejection Sensitivity and Reversed-Vegetative Symptoms are Similar to Younger Atypical Patients

Sachs‐Ericsson

Selby

Corsentino

et al. 2012

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

show abstract

“…Second, we do not claim that a dyshomeostasis-induced sense of low self-efficacy represents a single cause for the entire depression spectrum. Instead, we propose that it may play a particularly important role in melancholia, a subtype of depression with pronounced somatic symptoms and endocrine disturbances (Parker and Paterson, 2014) that differs physiologically from other forms of depression with respect to functional connectivity of visceromotor areas, including SGC and ACC (Guo et al, 2016). Indeed, model-based indices of individual interoception and allostatic control may provide a foundation for differential diagnosis and prognosis, a theme we return to below.…”

Section: A Hierarchical Bayesian View On Fatigue and Depression As Mementioning

confidence: 99%

Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression

Stephan

Manjaly

Mathys

et al. 2016

Front. Hum. Neurosci.

330

462

View full text Add to dashboard Cite

This paper outlines a hierarchical Bayesian framework for interoception, homeostatic/allostatic control, and meta-cognition that connects fatigue and depression to the experience of chronic dyshomeostasis. Specifically, viewing interoception as the inversion of a generative model of viscerosensory inputs allows for a formal definition of dyshomeostasis (as chronically enhanced surprise about bodily signals, or, equivalently, low evidence for the brain's model of bodily states) and allostasis (as a change in prior beliefs or predictions which define setpoints for homeostatic reflex arcs). Critically, we propose that the performance of interoceptive-allostatic circuitry is monitored by a metacognitive layer that updates beliefs about the brain's capacity to successfully regulate bodily states (allostatic self-efficacy). In this framework, fatigue and depression can be understood as sequential responses to the interoceptive experience of dyshomeostasis and the ensuing metacognitive diagnosis of low allostatic self-efficacy. While fatigue might represent an early response with adaptive value (cf. sickness behavior), the experience of chronic dyshomeostasis may trigger a generalized belief of low self-efficacy and lack of control (cf. learned helplessness), resulting in depression. This perspective implies alternative pathophysiological mechanisms that are reflected by differential abnormalities in the effective connectivity of circuits for interoception and allostasis. We discuss suitably extended models of effective connectivity that could distinguish these connectivity patterns in individual patients and may help inform differential diagnosis of fatigue and depression in the future.

show abstract

“…A promising attempt has been made currently to determine the nosological status and diagnostic strategies to melancholia (Parker and Paterson, 2014). Furthermore several biological markers have been suggested to identify this putative endophenotype.…”

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression

Rimay

Benák

Kiss

et al. 2015

Psychiatric Genetics

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) polymorphisms have been examined for their contribution to depression with equivocal results. More homogeneous phenotypes might be used to improve our understanding of genetic liability to depression. The aim of our study was to 1) test for association between BDNF Val66Met polymorphism and childhood onset melancholic depression and 2) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood onset melancholic depression. Materials and Methods 583 depressed probands were involved in this study (162 of the melancholic subtype). Diagnoses were derived via the Interview Schedule for Children and Adolescents - Diagnostic Version and life event data were collected by means of an Intake General Information Sheet Results 27.8% of the participants met criteria for melancholy. In the melancholic group the proportion of the females was higher (53.1%), though there were more males in the overall depressed sample. We detected no significant differences in genotype or allele frequency between the melancholic and the non-melancholic depressed group. BDNF Val66Met polymorphism and stressful life event interaction was not significantly associated with the melancholy outcome. Conclusion In our study, females are more prone to develop the early-onset melancholic phenotype. To our knowledge, this is the first study to investigate the differentiating effect of the genotype and the G×E interaction on melancholic phenotype in a large sample of depressed young patients. We didn’t find association between the melancolic subtype of major depression and the BDNF genotype and stressful life event interaction in this sample, which is representative to the Hungarian clinic-referred population of depressed youths.

show abstract

Melancholia

Cited by 17 publications

References 36 publications

Depressed Older Patients With the Atypical Features of Interpersonal Rejection Sensitivity and Reversed-Vegetative Symptoms are Similar to Younger Atypical Patients

Depressed Older Patients With the Atypical Features of Interpersonal Rejection Sensitivity and Reversed-Vegetative Symptoms are Similar to Younger Atypical Patients

Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression

BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression

Contact Info

Product

Resources

About