2019
DOI: 10.3892/or.2019.7161
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Abstract: Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. For the first time, the present study demonstrated that MEIS2 serves a role as a promoter of metastasis in CRC. In vivo and in vitro experim… Show more

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Cited by 15 publications
(19 citation statements)
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“…This result was later validated by luciferase reporter assay and qRT-PCR. MEIS2 promoted cell invasion and migration in colorectal cancer, 30 prostate cancer, 31 bladder cancer. 32 MEIS2 had the highest correlation with L-OHP resistance in colorectal cancer.…”
Section: Discussionmentioning
confidence: 97%
“…This result was later validated by luciferase reporter assay and qRT-PCR. MEIS2 promoted cell invasion and migration in colorectal cancer, 30 prostate cancer, 31 bladder cancer. 32 MEIS2 had the highest correlation with L-OHP resistance in colorectal cancer.…”
Section: Discussionmentioning
confidence: 97%
“…MEIS2 oncogene interacts with has-miR-192, thus decreasing its expression. Experimental evidences support the role of MEIS2 as oncogene [ 54 ] in colon cancer tissue and the role of tumor suppressor of has-miR-192 [ 55 ]. They interact with lncRNA RP11-553L6.5.…”
Section: Resultsmentioning
confidence: 91%
“…Enhanced cell migration is an important process for the metastasis of cancer cells and also a critical enhancing factor resulting in high mortality . As shown by some recent studies, some traditional Chinese medicines have been identified as effective anticancer drugs for various cancers ; however, the specific protective mechanisms of different herbal medicines are not the same.…”
Section: Discussionmentioning
confidence: 99%